Sign up to save your podcasts
Or
Share 130. Mast Cell Activation Syndrome - Discussing How Pathogenic Microbes Can Activate Mast Cells & Addressing Histamine-Producing and Histamine-Degrading Probiotics
Share to email
Share to Facebook
Share to X
Share to email
Share to Facebook
Share to X
Or
130. Mast Cell Activation Syndrome - Discussing How Pathogenic Microbes Can Activate Mast Cells & Addressing Histamine-Producing and Histamine-Degrading Probiotics
In this episode, we explore the role of probiotics in managing histamine levels and mast cell activation syndrome (MCAS), particularly in the context of rebuilding the gut microbiome. We discuss which probiotic strains could contribute to symptoms (in the short term) due to their histamine-producing properties, such as Lactobacillus casei and Lactobacillus reuteri, and we highlight beneficial strains that degrade histamine, including Lactobacillus plantarum.
Topics:
1. Introduction to Histamine and Mast Cell Activation
- Overview of histamine and mast cell activation syndrome (MCAS)
- Understanding histamine production
2. Breakdown of White Blood Cells (WBCs)
- Origin of WBCs from hematopoietic stem cells in the bone marrow
- Categories of WBCs: granulocytes, monocytes, and lymphocytes
3. Examination of Granulocytes
- Neutrophils: Role in bacterial infections
- Eosinophils: Role in allergic reactions and parasitic infections
- Basophils: Involvement in inflammatory and allergic responses through histamine release
- Mast Cells: Similarities to basophils, maturation in tissues, and histamine release
4. Examination of Agranulocytes
- Monocytes: Phagocytic function and differentiation into macrophages and dendritic cells
- Lymphocytes:
- T cells: Subtypes and their functions (helper T cells, cytotoxic T cells, regulatory T cells)
- B cells: Antibody-mediated immunity
- NK cells
5. Mast Cells vs. Basophils
- Location and function comparison
- Importance in histamine production
6. Mast Cell Activation Syndrome (MCAS)
- Triggers of MCAS (infections, environmental exposures, dietary factors, genetic predispositions)
- Focus on addressing root causes (lyme?, mold?, candida?, SIBO?, ...)
7. Probiotic Use in the Context of MCAS
- Probiotics and pathogenic microbes in the context of mast cell activation
8. Example: Candida and Mast Cell Interaction
- Recognition of Candida by mast cells through pattern recognition receptors (PRRs)
- Activation pathways and release of histamine and other inflammatory mediators
9. Probiotics and Histamine Production
- Probiotic strains that produce histamine
- Lactobacillus casei,
- Lactobacillus reuteri,
- Lactobacillus bulgaricus...
- Probiotic strains that do not produce histamine and/or degrade histamine
- Bifidobacterium infantis,
- Bifidobacterium longum,
- Bifidobacterium bifidum,
- Bifidobacterium breve,
- Lactobacillus plantarum,
- Lactobacillus rhamnosus,
- Lactobacillus gasseri,
- Lactobacillus salivarius
Thank you to our episode sponsors:
Liver Medic
Use code Chloe20 to save 20% on "Leaky Gut Repair"
Brendan's YouTube Channel
https://x.com/livermedic
Tremetes, LLC
Use code CHLOE15 to get 15% off Tremetes' Turkey Tail
Thanks for tuning in!
Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks"
Follow Chloe on Instagram @synthesisofwellness
Follow Chloe on TikTok @chloe_c_porter
Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
View all episodes
By Chloe Porter
4.8
6161 ratings
In this episode, we explore the role of probiotics in managing histamine levels and mast cell activation syndrome (MCAS), particularly in the context of rebuilding the gut microbiome. We discuss which probiotic strains could contribute to symptoms (in the short term) due to their histamine-producing properties, such as Lactobacillus casei and Lactobacillus reuteri, and we highlight beneficial strains that degrade histamine, including Lactobacillus plantarum.
Topics:
1. Introduction to Histamine and Mast Cell Activation
- Overview of histamine and mast cell activation syndrome (MCAS)
- Understanding histamine production
2. Breakdown of White Blood Cells (WBCs)
- Origin of WBCs from hematopoietic stem cells in the bone marrow
- Categories of WBCs: granulocytes, monocytes, and lymphocytes
3. Examination of Granulocytes
- Neutrophils: Role in bacterial infections
- Eosinophils: Role in allergic reactions and parasitic infections
- Basophils: Involvement in inflammatory and allergic responses through histamine release
- Mast Cells: Similarities to basophils, maturation in tissues, and histamine release
4. Examination of Agranulocytes
- Monocytes: Phagocytic function and differentiation into macrophages and dendritic cells
- Lymphocytes:
- T cells: Subtypes and their functions (helper T cells, cytotoxic T cells, regulatory T cells)
- B cells: Antibody-mediated immunity
- NK cells
5. Mast Cells vs. Basophils
- Location and function comparison
- Importance in histamine production
6. Mast Cell Activation Syndrome (MCAS)
- Triggers of MCAS (infections, environmental exposures, dietary factors, genetic predispositions)
- Focus on addressing root causes (lyme?, mold?, candida?, SIBO?, ...)
7. Probiotic Use in the Context of MCAS
- Probiotics and pathogenic microbes in the context of mast cell activation
8. Example: Candida and Mast Cell Interaction
- Recognition of Candida by mast cells through pattern recognition receptors (PRRs)
- Activation pathways and release of histamine and other inflammatory mediators
9. Probiotics and Histamine Production
- Probiotic strains that produce histamine
- Lactobacillus casei,
- Lactobacillus reuteri,
- Lactobacillus bulgaricus...
- Probiotic strains that do not produce histamine and/or degrade histamine
- Bifidobacterium infantis,
- Bifidobacterium longum,
- Bifidobacterium bifidum,
- Bifidobacterium breve,
- Lactobacillus plantarum,
- Lactobacillus rhamnosus,
- Lactobacillus gasseri,
- Lactobacillus salivarius
Thank you to our episode sponsors:
Liver Medic
Use code Chloe20 to save 20% on "Leaky Gut Repair"
Brendan's YouTube Channel
https://x.com/livermedic
Tremetes, LLC
Use code CHLOE15 to get 15% off Tremetes' Turkey Tail
Thanks for tuning in!
Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks"
Follow Chloe on Instagram @synthesisofwellness
Follow Chloe on TikTok @chloe_c_porter
Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
More shows like The Synthesis of Wellness®
View all
Boundless Life
5,003 Listeners
The Human Upgrade: Biohacking for Longevity & Performance
7,213 Listeners
The Jesse Chappus Show
1,541 Listeners
Dr. Ruscio Radio, DC: Health, Nutrition and Functional Healthcare
774 Listeners
The Cabral Concept
1,874 Listeners
The Neuro Experience
388 Listeners
The Funk'tional Nutrition Podcast
775 Listeners
The Genius Life
4,831 Listeners
Dhru Purohit Show
3,472 Listeners
The Dr. Hyman Show
9,273 Listeners
The Hunter Williams Podcast
69 Listeners
LONGEVITY with Nathalie Niddam
280 Listeners
The Dr. Tyna Show
1,649 Listeners
The Dr. Gabrielle Lyon Show
1,143 Listeners
The Peptide Podcast
76 Listeners