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136. Borrelia (Lyme) & The Brain - Neurological Manifestations of Chronic Lyme Disease, Blood-Brain Barrier Permeability, Symptoms, & Nervous System Support
In this episode, we delve into the complexities of how Borrelia burgdorferi, the bacterium responsible for Lyme disease, impacts the brain, leading to neuroinflammation and a spectrum of neurological symptoms. We'll explore the pathophysiology of Borrelia's interaction with the brain's blood-brain barrier, its evasion of the immune system, and the direct effects on neural cells. Additionally, we'll discuss specific neurological symptoms and manifestations.
Topics:
1. Introduction
- Overview of Lyme disease and its causative agent, Borrelia burgdorferi.
- Explanation of Borrelia's invasive nature and its ability to cross biological barriers like the blood-brain barrier (BBB).
2. Understanding the Blood-Brain Barrier (BBB)
- Endothelial Cells: Primary cellular component of the BBB, unique to the brain for their tightly joined structure.
- Astrocytes:
- Role in regulating blood flow through neurovascular coupling.
- Interaction with neurons and release of vasoactive substances.
- Contribution to BBB integrity by influencing tight junction formation.
- Pericytes:
- Contribution to BBB permeability and regulation through contractile capabilities.
3. Sponsor Break: Daily Nouri
4. Pathophysiology of Borrelia in the Brain
- Invasion Mechanisms:
- Borrelia’s ability to adhere to and invade endothelial cells.
- Role of surface proteins and induction of matrix metalloproteinases (MMPs).
- Immune Evasion and CNS Invasion:
- Antigenic variation to avoid immune detection.
- Triggering of immune responses within the CNS, involving microglia and peripheral immune cells.
- Cytokine production and its consequences on neuronal health.
5. Direct Impact on Brain Cells
- Neurons: Effects of Borrelia invasion on cellular functions, mitochondrial dysfunction, and apoptosis.
- Astrocytes: Transition to reactive astrocytes in the presence of Borrelia and their role in neuroinflammation.
- Oligodendrocytes: Impact on myelin production and implications for cognitive and motor functions.
6. Sponsor Break: AX3 Life
7. Neurological Symptoms and Manifestations
- Symptoms Overview: Headaches, facial palsy, cognitive impairments, nerve root inflammation, POTS.
- Psychiatric Manifestations: Potential psychological symptoms like depression and anxiety due to neuroinflammation.
8. Conclusion
- Importance of addressing neurological symptoms of Lyme through a bioindividual and root-cause approach.
- Recap of key points and reference to previous relevant episodes for further listening.
Thank you to our episode sponsors:
Check out Daily Nouri and use code CHLOE20 for 20% off your order.
Check out AX3 Astaxanthin and use discount code CHLOE20 for 20% off your first order.
Thanks for tuning in!
Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks"
Follow Chloe on Instagram @synthesisofwellness
Follow Chloe on TikTok @chloe_c_porter
Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
View all episodes
By Chloe Porter
4.8
6161 ratings
In this episode, we delve into the complexities of how Borrelia burgdorferi, the bacterium responsible for Lyme disease, impacts the brain, leading to neuroinflammation and a spectrum of neurological symptoms. We'll explore the pathophysiology of Borrelia's interaction with the brain's blood-brain barrier, its evasion of the immune system, and the direct effects on neural cells. Additionally, we'll discuss specific neurological symptoms and manifestations.
Topics:
1. Introduction
- Overview of Lyme disease and its causative agent, Borrelia burgdorferi.
- Explanation of Borrelia's invasive nature and its ability to cross biological barriers like the blood-brain barrier (BBB).
2. Understanding the Blood-Brain Barrier (BBB)
- Endothelial Cells: Primary cellular component of the BBB, unique to the brain for their tightly joined structure.
- Astrocytes:
- Role in regulating blood flow through neurovascular coupling.
- Interaction with neurons and release of vasoactive substances.
- Contribution to BBB integrity by influencing tight junction formation.
- Pericytes:
- Contribution to BBB permeability and regulation through contractile capabilities.
3. Sponsor Break: Daily Nouri
4. Pathophysiology of Borrelia in the Brain
- Invasion Mechanisms:
- Borrelia’s ability to adhere to and invade endothelial cells.
- Role of surface proteins and induction of matrix metalloproteinases (MMPs).
- Immune Evasion and CNS Invasion:
- Antigenic variation to avoid immune detection.
- Triggering of immune responses within the CNS, involving microglia and peripheral immune cells.
- Cytokine production and its consequences on neuronal health.
5. Direct Impact on Brain Cells
- Neurons: Effects of Borrelia invasion on cellular functions, mitochondrial dysfunction, and apoptosis.
- Astrocytes: Transition to reactive astrocytes in the presence of Borrelia and their role in neuroinflammation.
- Oligodendrocytes: Impact on myelin production and implications for cognitive and motor functions.
6. Sponsor Break: AX3 Life
7. Neurological Symptoms and Manifestations
- Symptoms Overview: Headaches, facial palsy, cognitive impairments, nerve root inflammation, POTS.
- Psychiatric Manifestations: Potential psychological symptoms like depression and anxiety due to neuroinflammation.
8. Conclusion
- Importance of addressing neurological symptoms of Lyme through a bioindividual and root-cause approach.
- Recap of key points and reference to previous relevant episodes for further listening.
Thank you to our episode sponsors:
Check out Daily Nouri and use code CHLOE20 for 20% off your order.
Check out AX3 Astaxanthin and use discount code CHLOE20 for 20% off your first order.
Thanks for tuning in!
Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks"
Follow Chloe on Instagram @synthesisofwellness
Follow Chloe on TikTok @chloe_c_porter
Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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