August 23, 2024

137. Supporting Brain Health & Cognitive Function by Harnessing the Power of the Gut Microbiome | Focusing on Microbial Metabolites Including SCFAs & Indole-3-Propionate

28 minutes

In today's episode, we dive into the crucial roles that gut-derived microbial metabolites, particularly short-chain fatty acids and tryptophan metabolites, play in supporting the health of neurons and glial cells, ultimately promoting cognitive function. We explore how enhancing the body’s natural production of these metabolites through a healthy gut microbiome and how strategic supplementation can both benefit brain health. The discussion includes detailed insights into the cellular mechanisms in the brain and practical strategies for fostering a healthy gut microbiome capable of producing high quantities of these beneficial compounds.

Topics:

1. Introduction to Brain Cellular Makeup

- Overview of Neurons and Glial Cells

- Neurons: Structure and Function

- Glial Cells: Types and Roles

2. Neuronal Communication and Synaptic Function

- Neuronal Structure: Soma, Dendrites, Axon

- Synaptic Communication: Presynaptic Terminal, Synaptic Cleft, Postsynaptic Membrane

3. Energy Demands

- ATP Utilization and Energy Demands

- Mitochondrial Function and Neuronal Vulnerability

4. Astrocytes and Microglial Cells

- Astrocytes: Functions and Role in CNS Homeostasis

- Microglial Cells: Immune Functions and Role in Neuroinflammation

5. Roles of Gut-Derived Microbial Metabolites in Supporting Brain Health

- Overview of Gut-Derived Metabolites

- Short-Chain Fatty Acids (SCFAs): Acetate, Propionate, Butyrate

- Tryptophan Metabolites: Indole, Indole-3-Propionate (IPA)

6. Impact of Gut-Derived Metabolites on Neurons

- Promotion of Neurogenesis by SCFAs

- Neuroprotective Effects of Tryptophan Metabolites

7. Impact of Gut-Derived Metabolites on Glial Cells

- Impact on Astrocytes

- Impact on Microglial Cells

8. Strategies to Enhance Metabolite Production

- Diversity

- Probiotic Supplementation

- Fiber

- Amino Acids

9. Direct Supplementation Options

- Sodium Butyrate: Role in Neuroprotection and Cognitive Function

Thank you to our episode sponsors:

1. Check out ⁠Daily Nouri⁠ and use code ⁠CHLOE20⁠ for 20% off your order.

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3. Check out ⁠⁠⁠⁠⁠⁠Liver Medic and use code Chloe20 to save 20% on ⁠⁠⁠⁠⁠⁠⁠⁠⁠"Leaky Gut Repair"⁠⁠⁠⁠⁠⁠⁠⁠⁠

⁠⁠⁠⁠⁠⁠⁠⁠⁠Brendan's YouTube Channel⁠⁠⁠⁠⁠⁠⁠⁠⁠

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