The Synthesis of Wellness

155. The Gut-Immune Axis & The Role That Gut-Microbiome Metabolites / Postbiotics Play | SCFAs, Polyphenol Metabolites, & Supporting Butyrate Production

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In this episode, we dive into the interplay between the gut microbiota (their postbiotics) and the immune system. We will examine how gut microbiome-derived metabolites, such as short-chain fatty acids (SCFAs) and polyphenol metabolites, influence immune function by modulating key cellular and molecular pathways within the intestinal mucosa. Additionally, we discuss strategies for supporting butyrate production and optimizing microbiome health to foster a balanced and resilient gut-immune axis.


Topics:

  • 1. Introduction

    • Overview of the gut-immune axis.
    • Importance of gut microbiome-derived metabolites in supporting immune function.

    • 2. The Intestinal Barrier

      • Layers of the intestinal wall
      • Focus on mucosa, specifically the epithelium and lamina propria.

      • 3. Structure of the Intestinal Layers

        • The intestinal lumen, mucus layer, epithelium (with tight junctions), and lamina propria.
        • Importance of the lamina propria as a hub for immune responses and structural integrity.

        • 4. Cellular and Structural Components of the Lamina Propria

          • Extracellular matrix (ECM): structural support.
          • Fibroblasts and myofibroblasts.
          • Lymphatic vessels: immune cell transport, linking mucosal and systemic immune systems.

          • 5. Immune Cells in the Lamina Propria

            • T cells: immune tolerance, regulatory T cells (Tregs).
            • B cells: Secretory immunoglobulin A (sIgA).
            • Dendritic cells: antigen sampling and presentation.
            • Macrophages: pathogen clearance.
            • Mast cells

            • 6. Role of Secretory Immunoglobulin A (sIgA)

              • Functions as a first-line defense in the intestinal mucus layer.
              • Neutralizes pathogens, prevents epithelial adhesion.

              • 7. Postbiotics Overview

                • Bioactive compounds produced by gut microbiota.
                • Examples: short-chain fatty acids (SCFAs)

                • 8. Short-Chain Fatty Acids (SCFAs) and Their Functions

                  • Influence on Treg cells in the lamina propria, promoting immune tolerance.
                  • Butyrate also as an energy source for epithelial cells.

                  • 9. Supporting Butyrate Production

                    • Microbiome optimization to enhance beneficial butyrate-producing microbes.
                    • Use of prebiotics: resistant starch, soluble fibers, and polyphenols.
                    • Supplementation with sodium butyrate as an additional tool.

                    • 10. Other Postbiotics

                      • Antimicrobial peptides produced by beneficial microbes.
                      • Complex carbohydrates produced by beneficial microbes and can act as prebiotics.
                      • Polyphenol metabolites: Gut microbiota biotransforms polyphenols into bioactive metabolites with increased bioavailability.

                        • 11. Specific Polyphenols

                        • Examples: resveratrol, quercetin, and ellagitannins.
                        • Effects on intestinal barrier function, inflammation, and immune cell populations.


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                          The Synthesis of WellnessBy Chloe Porter
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