The Synthesis of Wellness

156. The Oral Microbiome in Modulating Intestinal Health, the Intestinal Microbiome, and Brain Health | Examining The Oral-Gut-Brain Axis, Effects of Oral Dysbiosis, Neuroinflammation, & More

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In this episode, we go through the interplay between the oral microbiome, the intestinal microbiome, and brain health, focusing on the mechanisms through which dysbiosis in these ecosystems influences neuroinflammation and central nervous system function. We explore the molecular pathways by which bacterial metabolites and inflammatory mediators from the oral and intestinal microbiota can disrupt the blood-brain barrier, activate glial cells, and impair neuronal processes. We also go through symptoms associated with microbial imbalance as well as oral health practices.


Topics:

  • 1. Introduction

    • Focus on neuroinflammation, oral microbiome, and intestinal microbiome
    • Oral-gut-brain axis.

    • 2. Neuroinflammation Overview

      • Inflammatory response within the CNS.
      • Key cell types: Endothelial cells, neurons, glial cells (microglia, astrocytes, oligodendrocytes).
      • Acute vs. chronic neuroinflammation and their implications.

      • 3. Cellular Mechanisms

        • Microglial activation and its role in cytokine and ROS production.
        • Astrocytic contributions to neuroinflammation.

        • 4. Effects of Neuroinflammation on the Brain

          • Mitochondrial dysfunction and energy deficits in neurons.
          • Blood-brain barrier (BBB) disruption and immune cell infiltration.
          • Impacts on synaptic function and neuronal communication.
          • Potential contributors - environmental toxins, sleep deprivation, microbial dysbiosis, infections, and more.

          • 5. Role of the Intestinal Microbiome in Neuroinflammation

            • Dysbiosis and the release of LPS by Gram-negative bacteria.
            • LPS transport across the intestinal barrier (transcellular and paracellular pathways).
            • Systemic inflammation and its impact on BBB integrity and CNS inflammation.

            • 6. The Oral Microbiome and Brain Health

              • Direct effects of oral dysbiosis on systemic inflammation.
              • Indirect effects through oral-gut communication and intestinal dysbiosis.

              • 7. Trigeminal Nerve and Oral Dysbiosis

                • Role of the trigeminal nerve in sensory transmission.
                • Interaction of oral bacteria with the trigeminal nerve via TLRs and LPS recognition.

                • 8. Symptoms and Effects of Oral Dysbiosis

                  • Common symptoms
                  • Systemic effects on the intestinal microbiome and brain health.

                  • 9. Lifestyle Practices

                    • Oral health practices.

                    • 10. Conclusion

                      • Summary of the oral-gut-brain axis and its role in neuroinflammation.
                      • Importance of oral health in reducing inflammatory burdens.



                        • Thank you to our episode sponsor:

                        1. Check out Ulyana Organics' Tallow Wild Yam Cream and Healing Facial Oil, and use code CHLOE10 10% off your order.



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                        The Synthesis of WellnessBy Chloe Porter
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