December 27, 2024

157. Intestinal Mucus & Its Role in Protecting The Epithelium & Supporting The Intestinal Barrier, Interactions Between The HPA Axis & Microbiome, The MTHFR Gene & Methylation | 3 Top Topics from 2024

21 minutes

This episode explores three top topics from episodes in 2024: the mucus layer's protective role in maintaining gut barrier integrity, the bidirectional relationship between the microbiota-gut-brain axis and the hypothalamic-pituitary-adrenal (HPA) axis, and the importance of methylation and the MTHFR gene. During the first topic of discussion, we detail ways to support the intestinal mucus layer; as we approach the third topic of discussion, we highlight the impact of MTHFR enzyme activity on methylation, emphasizing its importance for many cellular processes.

Topics:

1. Introduction: 3 Top Topics of 2024

2. The Protective Mucus Layer Over the Intestinal Epithelial Lining

The intestinal barrier: intestinal lumen, microbiome, mucus layer, epithelial cells, lamina propria, and more.

The mucus layer functions as both a physical and biochemical barrier.

Goblet cells secrete mucins, which form the gel-like mucus layer, critical for maintaining barrier integrity.

Dysregulation of mucus turnover can lead to increased intestinal permeability and inflammation.

Supporting mucus levels: SCFAs, N-acetylglucosamine (NAG).

Plant-derived mucilage and sources.

3. HPA Axis and Microbiota-Gut-Brain Interactions

The HPA axis and the stress response.

Microbiota-gut-brain axis.

SCFAs produced by gut bacteria can influence gut barrier integrity and stress resilience.

Dysbiosis disrupts SCFA production, weakens the gut barrier, and triggers inflammation.

Dysbiosis and HPA axis dysregulation.

Chronic cortisol secretion and secretory IgA.

4. The MTHFR Gene and Methylation

Methylation involves transferring methyl groups.

The synthesis of SAMe, the universal methyl donor: methionine and ATP with active folate (L-methylfolate) as a precursor.

MTHFR gene polymorphisms reduce enzyme efficiency, impairing methylation and affecting DNA stability, neurotransmitter synthesis, and detoxification.

Strategies, supplements, and more to support methylation.

Thank you to our episode sponsor:

1. Check out ⁠Ulyana Organics'⁠ ⁠Tallow Wild Yam Cream⁠ and ⁠Healing Facial Oil⁠, and use code ⁠CHLOE10⁠ 10% off your order.

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