Sign up to save your podcasts
Or
Share 188. The Stomach | Symptoms of H. pylori & Hypochlorhydria, and a Conversation on the Effects of Low Stomach Acid on Micronutrient Absorption
Share to email
Share to Facebook
Share to X
Share to email
Share to Facebook
Share to X
Or
188. The Stomach | Symptoms of H. pylori & Hypochlorhydria, and a Conversation on the Effects of Low Stomach Acid on Micronutrient Absorption
In this episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance. The discussion also highlights the role of compromised gastric acidity in conditions such as small intestinal bacterial overgrowth (SIBO).
Topics:
1. Hypochlorhydria
- Low stomach acid.
- Aging, autoimmune gastritis, chronic PPI use, H. pylori infection.
2. H. pylori
- Common gram-negative bacterium that colonizes the stomach lining.
- Symptoms.
- Produces urease.
- Ammonia neutralizes acid, creating a protective microenvironment.
- Additional virulence factors and ability to form biofilms contribute to persistence.
3. Gastric Anatomy & Layers
- The stomach: hollow, muscular organ for mechanical and chemical digestion.
- Regions: Cardia, fundus, body, and pylorus.
- Layers: Mucosa, Submucosa, Muscularis externa, Serosa
4. Mucosal Layer
- Surface mucous cells secrete a thick bicarbonate-rich, protective mucus.
- Gastric pits lead to gastric glands, which contain specialized secretory cells.
5. Specialized Gastric Cells
- Parietal Cells: Secrete hydrochloric acid (HCl) and intrinsic factor (IF).
- Chief Cells: Secrete pepsinogen (converted to pepsin by HCl) and gastric lipase.
- Role of HCl: Activates pepsin, denatures proteins, and contributes to nutrient absorption.
- Intrinsic factor and vitamin B12 absorption.
6. Vitamin B12 Absorption
- Essential for DNA synthesis, RBC formation, neurological function.
- Released from food proteins by gastric acid and pepsin.
- Impaired absorption.
7. Role of Gastric Acid in Broader Micronutrient Absorption
- Absorption of minerals.
- Soluble, ionized state.
- Iron: HCl aids in preventing insoluble precipitates and supports iron absorption.
8. Protective Role of Gastric Acid
- Acts as a line of defense against ingested pathogens.
- Maintains low microbial diversity in the stomach.
- Low HCl and SIBO (Small Intestinal Bacterial Overgrowth).
9. Symptoms of Low Stomach Acid
- Bloating, early satiety, excessive belching.
- Undigested food in stool, chronic constipation.
- May reflect impaired enzymatic activation and digestive insufficiency.
10. Conclusion
- Multifactorial causes and downstream effects.
- Optimal range of stomach acid: neither high nor low.
Thank you to our episode sponsor:
1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX
2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.
Thanks for tuning in!
Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks"
Follow Chloe on Instagram @synthesisofwellness
Follow Chloe on TikTok @chloe_c_porter
Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
View all episodes
By Chloe Porter
4.8
6161 ratings
In this episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance. The discussion also highlights the role of compromised gastric acidity in conditions such as small intestinal bacterial overgrowth (SIBO).
Topics:
1. Hypochlorhydria
- Low stomach acid.
- Aging, autoimmune gastritis, chronic PPI use, H. pylori infection.
2. H. pylori
- Common gram-negative bacterium that colonizes the stomach lining.
- Symptoms.
- Produces urease.
- Ammonia neutralizes acid, creating a protective microenvironment.
- Additional virulence factors and ability to form biofilms contribute to persistence.
3. Gastric Anatomy & Layers
- The stomach: hollow, muscular organ for mechanical and chemical digestion.
- Regions: Cardia, fundus, body, and pylorus.
- Layers: Mucosa, Submucosa, Muscularis externa, Serosa
4. Mucosal Layer
- Surface mucous cells secrete a thick bicarbonate-rich, protective mucus.
- Gastric pits lead to gastric glands, which contain specialized secretory cells.
5. Specialized Gastric Cells
- Parietal Cells: Secrete hydrochloric acid (HCl) and intrinsic factor (IF).
- Chief Cells: Secrete pepsinogen (converted to pepsin by HCl) and gastric lipase.
- Role of HCl: Activates pepsin, denatures proteins, and contributes to nutrient absorption.
- Intrinsic factor and vitamin B12 absorption.
6. Vitamin B12 Absorption
- Essential for DNA synthesis, RBC formation, neurological function.
- Released from food proteins by gastric acid and pepsin.
- Impaired absorption.
7. Role of Gastric Acid in Broader Micronutrient Absorption
- Absorption of minerals.
- Soluble, ionized state.
- Iron: HCl aids in preventing insoluble precipitates and supports iron absorption.
8. Protective Role of Gastric Acid
- Acts as a line of defense against ingested pathogens.
- Maintains low microbial diversity in the stomach.
- Low HCl and SIBO (Small Intestinal Bacterial Overgrowth).
9. Symptoms of Low Stomach Acid
- Bloating, early satiety, excessive belching.
- Undigested food in stool, chronic constipation.
- May reflect impaired enzymatic activation and digestive insufficiency.
10. Conclusion
- Multifactorial causes and downstream effects.
- Optimal range of stomach acid: neither high nor low.
Thank you to our episode sponsor:
1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX
2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.
Thanks for tuning in!
Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks"
Follow Chloe on Instagram @synthesisofwellness
Follow Chloe on TikTok @chloe_c_porter
Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
More shows like The Synthesis of Wellness®
View all
Boundless Life
5,003 Listeners
The Human Upgrade: Biohacking for Longevity & Performance
7,213 Listeners
The Jesse Chappus Show
1,541 Listeners
Dr. Ruscio Radio, DC: Health, Nutrition and Functional Healthcare
774 Listeners
The Cabral Concept
1,874 Listeners
The Neuro Experience
388 Listeners
The Funk'tional Nutrition Podcast
775 Listeners
The Genius Life
4,831 Listeners
Dhru Purohit Show
3,472 Listeners
The Dr. Hyman Show
9,273 Listeners
The Hunter Williams Podcast
69 Listeners
LONGEVITY with Nathalie Niddam
280 Listeners
The Dr. Tyna Show
1,649 Listeners
The Dr. Gabrielle Lyon Show
1,143 Listeners
The Peptide Podcast
76 Listeners