Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

27. Why Blood Tests & Functional Medicine Tests Aren’t the Full Story: Gut, Histamines, Genes, Hormones & More!


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In this episode of The Histamine Well Podcast, host Joanne Kennedy and guest Mariella Gebhardt unpack the nuances of medical testing in functional medicine—and why lab results alone don’t always tell the full story.

From histamine intolerance and methylation issues to gut health, Candida, mold exposure, and hormone imbalances, Joanne and Mariela explore the limitations and benefits of testing while emphasizing the importance of case history, symptoms, and environmental factors in shaping treatment.

They break down popular tests—including organic acids tests (OAT), microbiome testing, genetic testing, thyroid panels, iron tests, and hormone testing—highlighting when they’re useful, what they may miss, and how to interpret them in real-world practice.

Whether you’re curious about functional medicine, women’s hormones, SIBO, oxalates, DAO enzyme activity, or vitamin B12 deficiency, this episode offers clarity on when testing helps—and when it can be misleading.

What You’ll Learn in This Episode:

  • Why clinical context matters more than test results alone
  • How to approach Candida, mold, and mycotoxin testing
  • The role of the DAO enzyme in histamine breakdown
  • Pitfalls of genetic and gene testing for methylation
  • How to interpret iron tests, thyroid panels, and hormone markers
  • Insights on organic acids, oxalates, and gut health testing

If you’ve ever wondered whether your test results reflect the whole picture—or how to navigate functional medicine testing with confidence—this conversation will help you understand the bigger picture.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

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Histamine Well Podcast: Exploring Histamine, Methylation & Holistic HealthBy Joanne Kennedy

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