Could sluggish bile be affecting your digestion, gut health and histamine symptoms?

In this episode of The Histamine Well Podcast, Joanne Kennedy explains the essential role bile plays in fat digestion, nutrient absorption, liver detoxification and microbial balance. She also explores how poor bile flow may contribute to SIBO, histamine intolerance and increased oxalate absorption.

Joanne breaks down four popular bile-support supplements—ox bile, TUDCA, taurine and phosphatidylcholine—including how each works, when it may be considered and why they are not interchangeable.

In This Episode, You’ll Learn:

• Common symptoms of sluggish or inadequate bile flow
• What happens to digestion after gallbladder removal
• How poor bile flow may contribute to SIBO and histamine intolerance
• The connection between fat malabsorption and oxalates
• How ox bile supports fat digestion
• How TUDCA supports liver health and bile flow
• Why taurine is needed to produce functional bile salts
• How phosphatidylcholine supports bile quality and methylation
• Important supplement precautions involving gallstones and bile duct obstruction

Listen now to understand how bile affects digestion—and how targeted support may benefit your liver, gallbladder and gut health.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well, Joanne explores the powerful connection between stress, cortisol, mast cell activation, and histamine intolerance. She explains how chronic stress can keep the nervous system trapped in fight-or-flight mode, trigger histamine release, and contribute to symptoms such as itching, flushing, headaches, sinus congestion, digestive issues, and skin reactions.

You’ll learn how the HPA axis responds to stress, why cortisol is helpful in the short term, and what can happen when the body becomes less responsive to cortisol’s anti-inflammatory effects. Joanne also discusses how reduced vagal tone may affect inflammation, mast cell reactivity, and the body’s ability to return to a calm, regulated state.

In this episode, you’ll discover:

• How stress activates the HPA axis and sympathetic nervous system
• The connection between cortisol, mast cells, and histamine
• Why chronic stress may worsen histamine intolerance and MCAS symptoms
• How stress-signalling molecules can trigger histamine release
• What glucocorticoid resistance is and how it may affect inflammation
• The role of the vagus nerve in immune and nervous-system regulation
• Why antihistamines may not address the upstream cause
• Practical ways to improve vagal tone and support nervous-system regulation

Joanne also shares simple strategies to help the body shift from fight-or-flight into rest-and-repair mode, including breathwork, humming, singing, gentle neck massage, and other vagus nerve exercises.

If your histamine symptoms seem to flare during periods of stress, this episode will help you understand why—and what you can do to begin breaking the stress–histamine cycle.

Resources mentioned:

• The Secret Language of the Body
• The Workout Witch nervous-system programs

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could oxalates be the hidden reason your histamine intolerance symptoms aren’t improving?

In this popular podcast replay, Joanne is joined by Melanie Peers to explore the often-overlooked connection between oxalates, histamine intolerance, inflammation, gut health, and nervous system dysregulation.

Oxalates are naturally occurring compounds found in many foods—including some commonly considered healthy. For sensitive individuals, a high oxalate load may contribute to pain, digestive problems, urinary symptoms, fatigue, and increased reactions to foods and supplements.

In this episode, Joanne and Melanie discuss:

• What oxalates are and how they can affect the body
• The connection between oxalates, histamine, and inflammation
• Common high-oxalate foods that may be contributing to symptoms
• Signs and symptoms associated with oxalate overload
• How gut health may influence oxalate absorption
• The impact of oxalates on minerals, sulfur, and important detoxification pathways
• Why some people develop multiple food and supplement intolerances
• The role of methylation and transsulfuration pathways
• Why nervous system regulation is an important part of recovery
• Why oxalates should be reduced carefully rather than eliminated too quickly

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

What is histamine, and why does it cause so many frustrating symptoms? 

In this replay of one of our most popular episodes, Joanne explains the science of histamine intolerance in a simple, practical way. Learn how histamine affects your immune system, gut health, hormones, brain, and skin, why histamine levels become too high, and the common symptoms of histamine intolerance—including migraines, anxiety, insomnia, hives, eczema, reflux, bloating, and more. 

Discover why a low-histamine diet alone isn't enough and why identifying the root cause is the key to lasting relief. 

Whether you're new to histamine intolerance or revisiting this episode, this is the perfect place to start your healing journey.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

One of our most downloaded episodes is back.

If you've been diagnosed with histamine intolerance, MCAS, or unexplained food sensitivities, this replay is one you won't want to miss.

In this listener-favorite episode, Joanne Kennedy explains why histamine intolerance is not a diagnosis—it's a symptom of deeper underlying health issues. While many people rely on a low histamine diet to manage symptoms, lasting improvement comes from identifying and treating the root causes driving excess histamine production.

Drawing on years of clinical experience, Joanne walks through the most common contributors to histamine intolerance, including SIBO, gut dysbiosis, leaky gut, digestive enzyme insufficiency, mold illness, oxalates, methylation issues, hormonal imbalances, and chronic inflammation.

Whether you're a practitioner, student, or someone struggling with chronic histamine symptoms, this episode will help you better understand why histamine intolerance develops—and where to start looking for answers.

Listen, Learn & Share

If this episode helps you better understand your histamine symptoms, please follow The Histamine Well Podcast, leave a review, and share it with someone searching for answers.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Many people with flushing, hives, anxiety, brain fog, digestive issues, food sensitivities, and heart palpitations are told they have either histamine intolerance or Mast Cell Activation Syndrome (MCAS). While these conditions can look remarkably similar, they have very different underlying mechanisms—and understanding those differences is often the key to finding the right treatment.

In this episode, Joanne explains the difference between histamine intolerance and MCAS, why symptoms overlap, and why some people continue to react despite following a low histamine diet. Drawing on her clinical experience, Joanne explores how histamine is processed in the body, the role of DAO and HNMT enzymes, common triggers for mast cell activation, and why addressing the root cause is essential for long-term recovery.

She also discusses the connection between mould mycotoxins, gut dysfunction, SIBO, oxalates, nervous system dysregulation, and histamine-related illness, while sharing practical insights into how she approaches assessment and treatment in clinical practice.

In this episode, you'll learn:

• The difference between histamine intolerance and Mast Cell Activation Syndrome (MCAS)
• Why these conditions share many of the same symptoms but require different treatment approaches
• How DAO and HNMT enzymes help regulate histamine in the body
• Common causes of histamine intolerance, including gut dysfunction, SIBO, mould exposure, oxalates, and hormone imbalances
• Why MCAS symptoms are often more severe, unpredictable, and triggered by non-food factors
• The connection between mould mycotoxins, chronic inflammation, and mast cell activation
• Which laboratory tests may be helpful—and why some commonly recommended tests have limited clinical value
• Joanne's clinical approach to identifying and treating the root causes of histamine-related symptoms

Whether you're navigating histamine intolerance, suspect MCAS, or you're a healthcare practitioner wanting a deeper understanding of these complex conditions, this episode provides practical, evidence-informed insights to help you take the next step towards better health.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Many women enter their 40s expecting a few hormonal changes, but are often unprepared for the anxiety, sleep disturbances, fatigue, low mood, histamine symptoms, weight changes, and nervous system shifts that can accompany perimenopause.

In this episode, Joanne shares her clinical and personal experience working with women through perimenopause and menopause, including her own journey with bioidentical oestrogen and progesterone. She discusses the signs of low oestrogen and progesterone, the limitations of standard hormone testing, and how bioidentical hormone therapy may support women during this transition.

You'll learn:

• The difference between perimenopause and menopause
• Common symptoms of low oestrogen and low progesterone
• How hormonal changes can influence histamine intolerance and mast cell activation
• Why hormone blood tests don't always tell the full story
• The potential benefits and challenges of bioidentical oestrogen and progesterone
• The connection between hormones, anxiety, sleep, mood, energy, libido, and weight
• Why hormone therapy should be individualised rather than one-size-fits-all

Whether you're navigating perimenopause yourself or supporting women through this stage of life, this episode offers practical insights to help you better understand the relationship between hormones, histamine, and healthy ageing.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Methylation has become one of the hottest topics in functional medicine, biohacking, and wellness. From MTHFR testing to methylated supplements, many people are being told that boosting methylation is the key to better energy, mood, detoxification, hormone balance, and longevity.

But what if more methylation isn't always better?

In this episode, Joanne explores the science behind methylation, the roles of MTHFR and COMT, and why relying solely on genetic reports can lead to inappropriate supplementation. Joanne explains the difference between undermethylation and overmethylation, the symptoms of excess methyl groups, and why many people experience worsening anxiety, insomnia, irritability, and other adverse effects when taking methylated supplements.

Whether you're a practitioner, student, or someone navigating histamine intolerance, hormone imbalances, or chronic health concerns, this episode provides a balanced, evidence-informed perspective on one of today's most talked-about health trends.

In this episode, you'll learn:

• What methylation is and why it's essential for health
• How methylation affects neurotransmitters, hormones, detoxification, and gene expression
• The difference between undermethylation and overmethylation
• The role of MTHFR, COMT, folate, and vitamin B12 in methylation pathways
• Common symptoms of excess methyl groups
• Why genetic testing alone doesn't tell the whole story
• The potential risks of methylated supplements
• A more personalised approach to methylation support

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could histamine be contributing to Premenstrual Dysphoric Disorder (PMDD)?

In this episode of The Histamine Well Podcast, Joanne explores the growing interest in the connection between PMDD, histamine intolerance, mast cell activation, and hormonal fluctuations. As more women report improvements in PMDD symptoms with antihistamines, the question is gaining attention: could histamine be a missing piece of the PMDD puzzle?

Joanne breaks down the science behind the estrogen-histamine feedback loop, explains how histamine interacts with estrogen and progesterone throughout the menstrual cycle, and discusses why some women experience worsening mood symptoms during the luteal phase.

You'll learn about the role of mast cells, neurotransmitters, neuroinflammation, and hormone sensitivity in PMDD, as well as the potential benefits and limitations of H1 and H2 antihistamines. Joanne also shares her clinical observations on histamine-related hormone symptoms and why addressing underlying drivers of histamine excess may be essential for long-term symptom improvement.

In This Episode You'll Learn:

• What PMDD is and how it differs from PMS
• The relationship between histamine and women's hormones
• How estrogen can increase histamine levels
• The role of progesterone in histamine regulation
• Mast cell activation and hormone-related symptoms
• Why histamine may worsen anxiety, irritability, and mood swings
• The science behind H1 and H2 blockers
• Potential risks of long-term antihistamine use
• Histamine's effects on neurotransmitters including serotonin and dopamine
• The connection between PMDD, MCAS, and histamine intolerance
• Why methylation may play a role in PMDD symptoms
• Common root causes of histamine excess, including SIBO, mold exposure, oxalates, and gut dysfunction
• Natural strategies for addressing histamine-related hormone symptoms

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Persistent fatigue is one of the most common—and most frustrating—symptoms experienced by people with mould illness. Many find that despite sleeping more, resting, pacing themselves, and trying countless supplements, the exhaustion simply doesn't improve.

In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould illness and mitochondrial dysfunction, revealing why fatigue can persist long after mould exposure has been identified.

You'll learn how three key factors often work together to impair cellular energy production:

• Mycotoxins and their direct toxic effects on mitochondria
• Sulfur depletion and reduced glutathione production
• Oxalate accumulation and mitochondrial stress

Joanne explains how these mechanisms can disrupt ATP production, increase oxidative stress, and contribute to symptoms such as chronic fatigue, brain fog, muscle weakness, exercise intolerance, post-exertional malaise, pain sensitivity, and temperature dysregulation.

This episode also explores the important relationship between mould exposure, gut dysbiosis, SIBO, sulfur metabolism, and oxalate overload—factors that are frequently overlooked when addressing ongoing fatigue and recovery from mould illness.

Whether you're a practitioner, student, or someone navigating chronic health challenges, this episode provides valuable insights into the biological processes driving fatigue and what may need to be addressed for meaningful recovery.

In this episode, you'll discover:

• How mould toxins damage mitochondrial function
• Why fatigue often persists despite rest and sleep
• The critical role of sulfur in energy production and detoxification
• How oxalates can contribute to mitochondrial dysfunction
• Common signs of mould-related mitochondrial impairment
• Why addressing mould exposure alone may not be enough for recovery

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!