In this episode of Live Foreverish, Dr. Mike and Dr. Crystal delve into the health nutrient SAMe (S-adenosyl-L-methionine), underscoring its numerous benefits for liver health, joint health, mood stabilization, and detoxification. They elucidate the biochemical process of methylation and its critical role in the body. The hosts review compelling research supporting SAMe's efficacy in treating osteoarthritis and major depressive disorder. They also tackle common questions about SAMe, such as optimal dosage, time to effectiveness, and complementary supplements. The episode highlights the potential of SAMe as a valuable addition to a health regimen.