The Synthesis of Wellness®

29. NAD+, Its Use in Energy Metabolism, Factors That Deplete NAD+ (Including Aging), 6 Strategies to Increase NAD+ Levels, & Thoughts on Using NAD+ Therapies for Mold Illness


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In today's episode, we are diving into NAD+ and exploring how it is a critical component for breaking down fuel, such as glucose, and ultimately converting that fuel to ATP. We will explore various factors that deplete NAD+ or decrease the NAD+/NADH ratio as well as 6 proven strategies to increase NAD+ within the body. Lastly, we wrap up the episode with a conversation pertaining to the use of NAD+ therapy for CIRS/Biotoxin illness, specifically Mold Illness. Thanks so much for tuning it!


Topics:


1. Understanding NAD+ and Its Role

- Definition of NAD+ and NADH

- Explanation of coenzymes in chemical reactions

- NAD+ and NADH as coenzymes for electron transfer

- Role in glucose metabolism and energy production

- Importance of NAD+ for various cellular functions


2. Glycolysis and NAD+

- Illustration of glucose metabolism and insulin release

- Role of GLUT4 transporters in glucose entry into cells

- Introduction to glycolysis and its steps

- Role of NAD+ as a coenzyme in glycolysis

- Generation of NADH during glycolysis


3. TCA (Krebs) Cycle and NAD+

- Transition of pyruvate to acetyl-coA

- Overview of the krebs cycle and its steps

- NAD+ as a coenzyme in the krebs cycle

- Accumulation of NADH during the cycle


4. Electron Transport Chain and NADH

- Movement of pyruvate into the mitochondria

- Role of NADH as an electron donor in the electron transport chain (ETC)

- ATP production through the ETC


5. Factors Disrupting NAD+ Balance

- Impact of toxins and pesticides on the ETC

- Role of drugs, like NSAIDs, in inhibiting the ETC

- Generation of reactive oxygen species (ROS)

- Role of ROS in mitochondrial damage and NAD+ depletion

- Link between NAD+ decline and aging

6. Consequences of NAD+ Depletion

- Effect of NAD+ reduction on metabolism

- Connection between NAD+ and metabolic diseases

- Therapeutic potential of NAD+ in age-related diseases


7. 6 Strategies for NAD+ Restoration

- Which supplemental NAD+ precursors are more effective

- Inhibition of the CD38 enzyme using dietary nutrients

- NAD+ IVs and patches: cost and quality

- Intermittent fasting

- Exercise and NAD+

- Other less well-known lifestyle factors that have a big impact on NAD+


8. NAD+ Therapies to Support Recovery from Mold Illness

- Link between NAD+ depletion and mold illness

- Thoughts on and logic behind the use of NAD+ therapies for CIRS recovery


Thanks for tuning in!

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The Synthesis of Wellness®By Chloe Porter

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