In this episode, we're delving into the fascinating world of sirtuins, exploring their role in countering the 9 hallmarks of cellular aging, and uncovering ways to optimize their activity for our benefit. We'll be exploring 7 proven strategies, backed by scientific research, that can effectively boost the expression of these longevity-promoting sirtuins within the body.

Topics:

1. Introduction

- Overview of NAD+ and its role in energy metabolism

- Previous discussion on strategies to increase NAD+ levels

- Importance of NAD+ in other reactions such as those mediated by sirtuins

2. Sirtuins: Introduction and Background

- Definition and origin of the term "sirtuins"

- Discovery of sirtuins and their role in yeast aging

- Transition from yeast cells to mammalian cells

- Introduction to SIRT1 as a focus for exploration

3. SIRT1: NAD+-Dependent Histone Deacetylase

- Role of SIRT1 as an NAD+-dependent histone deacetylase

- Gene silencing / gene expression

- SIRT1's influence on "genome stability" mediated by its ability to silence genes

4. SIRT1's Multi-Faceted Activities

- Beyond histone deacetylation: SIRT1's reach to non-histone proteins

- Deacetylation of p53 and suppression of cellular senescence

- Enhancement of telomere integrity

- Connecting these activities back to those 9 hallmarks of aging

5. The Sirtuin Enhancement Toolkit for Longevity: 7 Strategies

- Resveratrol and Pterostilbene

- Increasing NAD+ availability through various methods

- Exercise's influence on SIRT1 expression

- DHA (Omega-3 fatty acid) and its role in activating SIRT1

- Zinc's importance for SIRT1's structural integrity and function

- Nutraceuticals: Berberine, quercetin, fisetin, and curcumin

- Intermittent fasting and its impact on NAD+ levels and SIRT1

Thanks for tuning in!

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

Follow Chloe on Instagram @synthesisofwellness

Follow Chloe on TikTok @chloe_c_porter

Visit ⁠synthesisofwellness.com⁠ to purchase products, subscribe to our mailing list, and more!

Or visit ⁠linktr.ee/synthesisofwellness⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show!

Thanks again for tuning in!