August 25, 2023

33. MOTS-c (Peptides Episode) - The New Way to Support Insulin Sensitivity, Increasing MOTS-c Naturally, & How MOTS-c Could Enhance Your Workout + Combat Post-Menopausal Weight Gain

34 minutes

Today's episode is filled with peptide therapy, informational gems surrounding MOTS-c! We explore how MOTs-c triggers AMPK pathway activation, enhancing fatty acid oxidation and glycolysis, leading to increased ATP production and reduced "fat storage." Additionally, the episode highlights MOTs-c's role in addressing insulin resistance, evident from studies demonstrating lowered glucose and insulin levels in high-fat diet-induced obese mice and reduced menopausal weight gain. Moreover, the peptide's impact on mitochondrial biogenesis and skin health was discussed, emphasizing its potential to combat aging-related issues. Thanks for tuning in!

Topics:

1. Introduction:

- Overview of mitochondria's role in energy metabolism

- Explanation of energy metabolism process

- Importance of mitochondria in energy metabolism and aging

2. MOTs-c: Mitochondrial-Derived Peptide:

- Role of mitochondria's genetic material and protein encoding

- Introduction to MOTs-c and its translocation

- Age-dependent expression and presence of MOTs-c

3. AMPK Pathway Activation by MOTs-c:

- Explanation of AMPK as an energy sensor

- AMPK activation mechanism by MOTs-c

- Resulting increase in fatty acid oxidation and glycolysis

- AMPK's role in inactivating ACC in order to prevent fatty acid storage (more fat "burning," less fat "storage")

4. MOTs-c's Impact on Insulin Resistance:

- Study on high-fat diet-induced obese mice injected with MOTs-c

- Lowered glucose and insulin levels in MOTs-c-treated mice

- Reduced oxidative stress and enhanced cellular stress resistance

- Study on normal and pre-diabetic patients showing lower MOTs-c levels in T2D

5. Mitochondrial Biogenesis and PGC1-alpha Activation:

- Explanation of mitochondrial biogenesis

- Role of PGC1-alpha in mitochondrial health and biogenesis

- AMPK activation by MOTs-c leading to PGC1-alpha transcription

- Stimulation of generation of new, healthy mitochondria

6. MOTs-c's Impact on Aging and Skin Health:

- MOTs-c's influence on increasing NAD+ levels through AMPK activation

- Necessity of NAD+ for longevity-enhancing sirtuins

- MOTs-c's potential to combat age-related decline in NAD+

- Study indicating MOTs-c's potential in preventing skin aging

7. MOTs-c and Menopause:

- MOTs-c's potential in reducing weight gain and insulin resistance in menopause

- MOTs-c's effects on enhancing insulin sensitivity

8. Peptide Therapy Using MOTs-c:

- Explanation of peptide therapy and MOTs-c administration

- Caution and recommendation to work with licensed peptide physicians

9. Boosting Endogenous MOTs-c Production:

- Human studies showing MOTs-c increases through exercise

- Combination of exercise and peptide therapy for enhanced MOTs-c synergy

- Personal experience with mitochondrial-focused therapies: an example stack

Thanks for tuning in!

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Thanks again for tuning in!

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By Chloe Porter

4.8

6161 ratings