This conversation is with Dr Oscar Serrallach, GP and author of the ground-breaking book, The Postnatal Depletion Cure. In both his clinical work, and as a father to his three children, Oscar has witnessed the enormous stress of modern motherhood and the health implications experienced by mothers. He has dedicated his career to addressing what he terms ‘postnatal depletion’. In this episode we discuss what postnatal depletion is, what causes it, as well as treatment and prevention strategies – which are both physiological and social. Dr Oscar discusses neuroinflammation and challenges mainstream understandings of maternal mood disorders, relaying important findings on how postnatal depression is distinct from depression experienced by those who are not mothers. He discusses the changes that happen to a mother’s brain during pregnancy and postnatally, and how our stress response system is impacted. Dr Oscar importantly frames these changes as a ‘superpower’ and highlights the critical importance of mothering-work. We talk about matrescence, why motherhood continues to be devalued, and what our hopes are for the future of maternal advocacy and change.