June 10, 2025

#342: Unlocking The Secret Code To Fasting: The Biohack for Hunger, Longevity & Energy (How Scientists Are Hacking Your CELLS) | Chris Rhodes

1 hour 20 minutes

Welcome back to the Longevity Podcast! I’m so excited for today’s episode, where I sit down with Chris Rhodes—nutritional biochemist, fasting researcher, and CEO of Mimio Health—to dive deep into one of the most fascinating emerging topics in longevity science: fasting mimetics. If you’ve ever wanted to get the regenerative, anti-inflammatory, and health-boosting effects of fasting, but struggled to actually fast for 36 hours or more (trust me, I get it!), this conversation is for you.

Listeners of this podcast can visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order.

What we discuss:

Meet Chris Rhodes and his biomimetic research journey ... 00:05:18

Unlocking fasting benefits without prolonged fasting ... 00:09:10

Supplements vs. pharmaceuticals for longevity ... 00:10:53

Fasting protocols, timing, and metabolic switching ... 00:15:23

Risks of fasting, evolutionary adaptation, and muscle/bone loss ... 00:18:34

Ketones, brain energy, and cognitive adaptation ... 00:22:48

How fasting activates longevity and repair pathways ... 00:26:23

Key cellular pathways: AMPK, mTOR, NAD, sirtuins ... 00:28:04

Mimio research: discovering and testing fasting metabolites ... 00:33:35

The four main fasting mimetic molecules explained ... 00:42:04

Practical benefits: who should use fasting mimetics & safety ... 00:59:00

Mimio in use: hunger control, GLP-1 support, and older adults ... 01:03:37

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