August 12, 2025

#360: How Liz Parrish Is REWRITING the Rules of Aging (Gene Therapy, Telomeres & The Future of Longevity)

1 hour 22 minutes

Today, I’m joined by the trailblazing Liz Parrish, a true pioneer in the world of longevity science and regenerative medicine. Liz doesn’t just talk about cutting-edge gene therapies—she’s the first patient to actually undergo many of them herself. In our conversation, Liz shares how her journey from stem cell advocacy to biotech innovation was fueled by a deeply personal mission: her son’s diagnosis with type 1 diabetes.

What we discuss:

How Liz Parrish got into genetics and stem cells ... 00:06:45

Transition from childhood disease to treating aging ... 00:09:35

Difference between stem cells, gene therapy, and exosomes ... 00:14:20

Challenges in gene therapy delivery and cell reprogramming ... 00:19:22

Liz Parrish as patient zero for gene therapies ... 00:22:01

Results and lessons from Parrish’s self-experimentation ... 00:23:16

Senescent cells, telomeres, and aging interventions ... 00:29:22

Evolution and progress in gene therapy ... 00:34:14

Barriers and ethics of gene therapy for rare diseases and children ... 00:36:53

Public perception and future accessibility ... 00:44:55

Affordability, scaling, and redosing gene therapies ... 00:55:00

Practical longevity habits and hormones ... 01:03:54

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