Histamine intolerance is typically mild, but Mastocytosis is the most severe form of mast cell disorder—often taking nearly a decade to diagnose. Symptoms can affect multiple organs, from rashes and GI issues to life-threatening anaphylaxis, and standard treatments like low-histamine diets and antihistamines often fail.

Many doctors aren’t familiar with testing or treatment options for mast cell issues like Mastocytosis and MCAS.

Today, I’m joined by Dr. Mariana Castells, a leading expert in allergy and immunology at Brigham and Women’s Hospital. She directs the renowned Mastocytosis Center and the Drug Hypersensitivity and Desensitization Center.

Even if you have histamine intolerance or MCAS, this episode offers key insights on histamine, testing, and finding real relief—because no one should suffer needlessly.

⭐️Mentioned in This Episode:

- Connect with Dr. Castells at https://bit.ly/3ItFhU2 

- Histamine Overload Masterclass 👉https://www.skinterrupt.com/histamineresetmc-pod

- HistaGut Relief IgG 👉 https://www.skinterrupt.com/histagut-pod 

- See all the references 👉 http://www.skinterrupt.com/390 

- Join in the conversation with Jennifer at http://instagram.com/jenniferfugo 

- Stop My Rashes FREE eGuide - https://www.skinterrupt.com/stopmyrashes-pod

- Fix your skin using Jennifer’s method (trusted by 900+ skin rash warriors)! Get started NOW 👉 https://www.skinterrupt.com/srrdiy-pod

- Want personalized help to fix your skin? Get started here with Jennifer’s virtual clinic 👉 https://www.skinterrupt.com/gethelp-pod (We work with clients worldwide!)

🎙 This episode is brought to you by:

Quell Essentials Skincare + Supplements for Sensitive Skin 👉https://www.quellshop.com use code POD15 for 15% off 

Ready to figure out your skin’s root causes so you can finally fix your skin + break free from meds + flare ups?

My virtual clinic works with adults worldwide struggling with eczema, psoriasis, rosacea, urticaria, hives, dandruff, perioral dermatitis + more.

Trusted by 1000+ clients, we get results WITHOUT restrictive elimination diets.

Schedule an assessment call at https://skinrepaircall.com/