September 18, 2023

43. AT-1001 (The Leaky Gut Peptide Supplement No One is Talking About) - How it Works, Where to Get it, Why No One Knows About it + A Deep Dive into Zonulin Release & Gut Permeability

31 minutes

Today's episode dives into a not-so-well-known oral peptide supplement, formerly called AT-1001, and now referred to as larazotide acetate. We go over what this peptide does within the gut, how it blocks zonulin receptors, where to get it, why it's not well-known, and so much more! Truly, the research is pretty incredible and intriguing, so stay tuned... because this peptide could very well be the next game-changing supplement for "leaky gut!"

Topics:

1. Discussion on Anti-Zonulin Peptide Compound

- Introduction to the topic

2. The Gut Lining's Structure and Composition

- Villi and Microvilli: Enhancing Surface Area

- The presence and importance of crypts

- Monolayer of epithelial cells explained

3. Different Types of Cells in the Gut Lining

- Enterocytes: Absorption of Nutrients

- Goblet Cells: Mucus Secretion

- Paneth Cells: Antibacterial Function

- M Cells: Immune Surveillance

- Enteroendocrine Cells: Hormone Secretion

- Stem Cells: Renewal and Replenishment

4. Tight Junctions: Ensuring Gut Integrity

- Definition and importance of tight junctions

- Components of tight junctions: Claudins, Occludin, JAMs

- Interaction with the cytoskeleton through ZO proteins

- Dynamic regulation in response to various conditions

5. Zonulin's Role in Intestinal Permeability

- Gliadin's interaction with enterocytes leading to zonulin release

- Zonulin's impact on the cytoskeleton and, therefore, tight junctions

- Gliadin peptides' interaction with immune cells and celiac disease

6. Other Factors Influencing Zonulin Release and Gut Integrity

- List of factors that directly or indirectly affect gut integrity

7. Larazotide Acetate: A Novel Peptide Compound

- Definition and mechanism of action

- Real-world implications and studies

8. Current State and Future of Larazotide Acetate

- Studies and their discontinuation?

- Its emergence in peptide supplement companies

- The importance of consulting with medical professionals

Thanks so much for tuning in!

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By Chloe Porter

4.8

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