The Holistic GLP-1 Podcast with Elizabeth McGann

#48 - The Hidden Heart Benefits of GLP-1s (with Dr. Ralph DeFronzo)


Listen Later

In this breakthrough episode, Dr. Ralph DeFronzo—one of the most respected names in metabolic health—joins Elizabeth to discuss the real story behind GLP-1 medications.

If you’ve ever wondered:

Do I have to stay on GLP-1s forever?

Are lower doses (or “microdoses”) actually effective?

Can I activate GLP-1 naturally—without prescriptions?

Is it really safe for long-term use?

…this episode gives you honest answers, straight from an expert who helped define modern diabetes treatment.

Dr. D explains how GLP-1s not only facilitate weight loss by reducing one’s appetite, but also protect your heart, liver, brain and kidneys—and why most people overlook this crucial benefit. You’ll learn what makes someone a “super responder,” the link between cortisol and weight loss resistance, and how to finally quiet “Food Noise” for good. ✨

 

***

CLICK HERE TO GET ==>  FREE "Freedom From Food Noise" Masterclass:

https://go.elizabethmcgann.com/start

***

 

SHOW NOTES:

[ 00:00 ] Introduction

[ 01:45 ] GLP-1s: Not just for weight loss—they also protect your heart, liver, kidneys & brain

[ 03:40 ] People often forget: GLP-1s were originally created to treat diabetes

[ 07:35 ]  Are low doses (aka “microdosing”) effective? DeFronzo’s take on trending wellness practices

[ 10:55 ] Significant benefits of GLP-1s for non-diabetics

[ 13:25 ] How much weight do you really need to lose to help your heart? The 10% threshold explained

[ 15:55 ] “Weighted” Question: Once on them, do you need to be on GLP-1s forever? The real answer from an expert who knows

[ 19:30 ] Why diet and exercise alone don’t work long-term for most people—and what actually does work

[ 22:30 ] Can you “reverse” diabetes or insulin resistance naturally? The symptoms, YES... but it’s complicated!

[ 25:00 ] How GLP-1s reduce inflammation and rewire your metabolism at the cellular level

[ 28:00 ] The truth about “natural” GLP-1 boosters like berberine, fiber and protein

[ 31:00 ] Dr. DeFronzo’s surprising eating habit—and what it reveals about fasting myths

[ 35:00 ] How GLP-1s may help food addiction by rewiring brain circuitry

[ 39:45 ] Insights from four-year safety data: What we do and don’t know about long-term use

[ 42:00 ] Black box warnings and thyroid cancer risk—what’s real and what’s hype?

[ 44:50 ] Can someone taper off of GLP-1s successfully? Who are the 10–15% that do—and how?

[ 49:00 ] Will future GLP-1s render current meds obsolete? Why retatrutide may change the game

[ 56:00 ] Super-responders vs. non-responders—and the cortisol connection you’ve never heard

[ 59:00 ] Why Dr. DeFronzo thinks the next big breakthrough will be insulin-sensitizers

[ 01:02:00 ] Final thoughts: a hopeful but cautionary note about access, cost and a new generation of GLP-1s on the way

 

***

🔗 Mentioned in This Episode: Learn how to activate GLP-1 naturally and silence cravings! CLICK HERE TO GET ⇒ Free Masterclass: Freedom From Food Noise: https://go.elizabethmcgann.com/start

 

***

 

Get Connected with Elizabeth McGann:

Coaching Website: http://www.ElizabethMcGann.com

Instagram: http://www.instagram.com/elizabethmcgann

Facebook: https://www.facebook.com/ElizabethMcGannWellness

LinkedIn: https://www.linkedin.com/in/elizabethmcgann

X/Twitter: https://twitter.com/ElizabethMcGann

 

***

Learn more about Dr. Ralph DeFronzo:

University of Texas Health San Antonio Bio : https://directory.uthscsa.edu/academics/profile/defronzo

Appearance on Dr. Peter Attia’s THE DRIVE Podcast: https://www.youtube.com/watch?v=vYQaLV3Fm00

Dr. DeFronzo’s Work: Just Google him—you’ll find over 900 scientific publications!

...more
View all episodesView all episodes
Download on the App Store

The Holistic GLP-1 Podcast with Elizabeth McGannBy Elizabeth McGann

  • 5
  • 5
  • 5
  • 5
  • 5

5

43 ratings


More shows like The Holistic GLP-1 Podcast with Elizabeth McGann

View all
Well Beyond 40 by JJ Virgin

Well Beyond 40

1,095 Listeners

Optimal Protein Podcast with Vanessa Spina by Vanessa Spina

Optimal Protein Podcast with Vanessa Spina

780 Listeners

Everyday Wellness with Cynthia Thurlow ™ by Everyday Wellness™

Everyday Wellness with Cynthia Thurlow ™

1,208 Listeners

Midlife Conversations with Natalie Jill by Natalie Jill

Midlife Conversations with Natalie Jill

634 Listeners

The Hormone Solution with Karen Martel by Karen Martel Hormone Specialist

The Hormone Solution with Karen Martel

334 Listeners

The Hunter Williams Podcast by Hunter Williams

The Hunter Williams Podcast

69 Listeners

The Thyroid Fixer by Dr. Amie Hornaman

The Thyroid Fixer

514 Listeners

The Dr. Tyna Show by Dr. Tyna Moore

The Dr. Tyna Show

1,649 Listeners

Docs Who Lift by Docs Who Lift

Docs Who Lift

370 Listeners

The Peptide Podcast by The Peptide Queen

The Peptide Podcast

76 Listeners

The Obesity Guide with Matthea Rentea MD by Matthea Rentea MD

The Obesity Guide with Matthea Rentea MD

203 Listeners

The Plus SideZ: A Guide to GLP-1 & Metabolic Health by Kim Carlos

The Plus SideZ: A Guide to GLP-1 & Metabolic Health

192 Listeners

On The Pen With Dave Knapp by Dave Knapp Man On The Mounjaro, Bleav

On The Pen With Dave Knapp

239 Listeners

GLP-1 Hub: Support, Community, and Weight Loss by Ana Reisdorf, MS, RD

GLP-1 Hub: Support, Community, and Weight Loss

65 Listeners

GLP-1 Tribe by Eric Eden

GLP-1 Tribe

30 Listeners