Today, I am diving into the antimicrobial synergy between a bioactive compound called CAPE (found in propolis) and the LL-37 antimicrobial peptide. We explore how and why these may act synergistically and further dive into my personal antimicrobial stacks. You don't want to miss this one!

Topics:

1. Introduction to Propolis

- Definition of Propolis

- How Bees Produce Propolis

- Functions of Propolis in the Hive

- Factors Influencing Propolis Composition

2. Key Bioactives in Propolis

- Overview of Bioactive Compounds

- Notable Compound: Caffeic Acid Phenethyl Ester (CAPE)

3. CAPE's Biological Activities

- Modulating Inflammation

- Inhibiting Arachidonic Acid (AA) Release From Cell Membrane

- Impact on Prostaglandin and Leukotriene Production

- Inhibition of LOX and COX Enzymes

4. CAPE's Anti-Biofilm and Antimicrobial Properties

- Effectiveness Against Candida albicans

- Inhibition of Biofilm Formation

- Stimulation of Endogenous Antimicrobial Peptides

- Focus on β-defensin 3

- Synergy with LL-37 Peptide

5. LL-37 Peptide

- Introduction to Cathelicidins

- Role of LL-37

- Mechanism of Action

- Immunomodulatory Effects

6. Considerations and Precautions

- Potential Herxheimer Reaction

- Dosage for LL-37

- Dosage Estimate for CAPE in Propolis

7. Conclusion and Safety

- Importance of Consulting a Licensed Physician

- Wrapping Up the Discussion

Thanks for tuning in!

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