The Thyroid (and Hormone) Fixer Podcast: Thyropause, Menopause, Metabolism and How to Fix It

636. How to Titrate Up Your T3 the RIGHT Way


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In this episode, I’m answering one of the most common questions I receive from patients: how do you actually titrate T3 safely and effectively? We walk through the practical side of increasing both natural desiccated thyroid medications and T3 medications like Cytomel or liothyronine, including why the process looks different for different people. I explain how T3 works in the body, why sensitivity varies so much from person to person, and what symptoms can signal that you’re moving too quickly - or not quickly enough.

I also discuss the realities of thyroid optimization, including why progress is rarely linear and why patience is often one of the hardest parts of the process.


What you’ll learn:

  • Why T3 titration is rarely a one-size-fits-all process

  • How natural desiccated thyroid medications differ from standalone T3 medications

  • The role sensitivity to caffeine, stimulants, and medications may play in determining dosing strategies

  • What symptoms can suggest you’ve increased your dose too quickly

  • Why reverse T3 is an important marker to monitor during thyroid treatment

  • How to think about dose increases when progress feels inconsistent

  • The potential drawbacks of remaining on very low doses of T3 long term

  • Why thyroid optimization often requires ongoing adjustments rather than a fixed protocol

    If you're currently taking T3, considering adding it to your treatment plan, or wondering why thyroid medication hasn't produced the results you expected, this episode will help you better understand the titration process and the factors that can influence how you respond. 


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