Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.
This episode is brought to you by:
Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)
Momentous high-quality creatine: https://livemomentous.com/tim (code TIM for up to 35% off)
AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs)
Timestamps:
[00:00:00] Start.
[00:14:43] Why I'm interested in ketogenic strategies for neurodegenerative prevention.
[00:16:18] Mary and Steve Newport's ketone-linked temporary cognitive improvements.
[00:18:18] A mechanisms overview for Alzheimer's/dementia.
[00:21:25] The immune system as longevity's "fifth horseman" — and why metabolic control is key.
[00:22:04] How to measure ketones and GKI.
[00:23:00] Fasting vs. ketogenic diet.
[00:24:18] There's nothing fishy about sardine fasting.
[00:28:32] My hiatal hernia discovery and increased cancer risk concerns.
[00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular risk.
[00:31:57] Glucose tolerance testing revelations and CGM importance.
[00:31:57] Upgrading the metabolic machinery through keto without getting bored.
[00:42:07] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.
[00:43:42] Dom's day-to-day diet regimen.
[00:45:56] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.
[00:51:30] Supplementing for sleep disruption while fasting.
[00:55:41] Why Dom doesn't have misgivings about melatonin.
[00:59:15] Shingles prevention through fasting protocols.
[01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.
[01:03:54] Dom at 50-something: Current meal timing and composition.
[01:05:57] Blue zone observations: Greek and Sardinian longevity habits.
[01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.
[01:15:18] Ketone metabolic therapy for cancer.
[01:18:15] The metabolic psychiatry revolution.
[01:22:10] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.
[01:28:27] Metformin vs. berberine.
[01:31:43] The low-dose neuroprotective potential of GLP-1 drugs.
[01:34:58] NAD research: MIB-626 and stabilized forms for mitochondrial health.
[01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.
[01:42:05] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.
[01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.
*
Show notes for this episode: https://tim.blog/2025/09/03/dr-dominic-dagostino-all-things-ketones/
For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.
For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors
Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.
For transcripts of episodes, go to tim.blog/transcripts.
Discover Tim’s books: tim.blog/books.
Follow Tim:
Twitter: twitter.com/tferriss
Instagram: instagram.com/timferriss
YouTube: youtube.com/timferriss
Facebook: facebook.com/timferriss
LinkedIn: linkedin.com/in/timferriss
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
View all episodes
By Tim Ferriss: Bestselling Author, Human Guinea Pig
4.6
1573215,732 ratings
Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.
This episode is brought to you by:
Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)
Momentous high-quality creatine: https://livemomentous.com/tim (code TIM for up to 35% off)
AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs)
Timestamps:
[00:00:00] Start.
[00:14:43] Why I'm interested in ketogenic strategies for neurodegenerative prevention.
[00:16:18] Mary and Steve Newport's ketone-linked temporary cognitive improvements.
[00:18:18] A mechanisms overview for Alzheimer's/dementia.
[00:21:25] The immune system as longevity's "fifth horseman" — and why metabolic control is key.
[00:22:04] How to measure ketones and GKI.
[00:23:00] Fasting vs. ketogenic diet.
[00:24:18] There's nothing fishy about sardine fasting.
[00:28:32] My hiatal hernia discovery and increased cancer risk concerns.
[00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular risk.
[00:31:57] Glucose tolerance testing revelations and CGM importance.
[00:31:57] Upgrading the metabolic machinery through keto without getting bored.
[00:42:07] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.
[00:43:42] Dom's day-to-day diet regimen.
[00:45:56] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.
[00:51:30] Supplementing for sleep disruption while fasting.
[00:55:41] Why Dom doesn't have misgivings about melatonin.
[00:59:15] Shingles prevention through fasting protocols.
[01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.
[01:03:54] Dom at 50-something: Current meal timing and composition.
[01:05:57] Blue zone observations: Greek and Sardinian longevity habits.
[01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.
[01:15:18] Ketone metabolic therapy for cancer.
[01:18:15] The metabolic psychiatry revolution.
[01:22:10] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.
[01:28:27] Metformin vs. berberine.
[01:31:43] The low-dose neuroprotective potential of GLP-1 drugs.
[01:34:58] NAD research: MIB-626 and stabilized forms for mitochondrial health.
[01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.
[01:42:05] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.
[01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.
*
Show notes for this episode: https://tim.blog/2025/09/03/dr-dominic-dagostino-all-things-ketones/
For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.
For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors
Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.
For transcripts of episodes, go to tim.blog/transcripts.
Discover Tim’s books: tim.blog/books.
Follow Tim:
Twitter: twitter.com/tferriss
Instagram: instagram.com/timferriss
YouTube: youtube.com/timferriss
Facebook: facebook.com/timferriss
LinkedIn: linkedin.com/in/timferriss
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
11,910 Listeners
5,377 Listeners
2,670 Listeners
1,655 Listeners
2,071 Listeners
8,317 Listeners
1,215 Listeners
8,099 Listeners
4,819 Listeners
2,139 Listeners
2,654 Listeners
9,794 Listeners
298 Listeners
1,314 Listeners
29,224 Listeners
258 Listeners
1,060 Listeners
0 Listeners