In this week's SuperAge podcast, we're joined by Dr. Vonda Wright, an orthopedic sports doc and surgeon renowned for her expertise in athletes and active individuals of all ages. Dr. Wright delves into the complexities of joint health, emphasizing the importance of cartilage and its vulnerability to wear and trauma. She underscores the significance of maintaining an anti-inflammatory lifestyle and the critical role of strength in protecting and supporting our joints. Her insights extend from the nuances of treating elite athletes to offering holistic strategies for those seeking to sustain their physical health into later life. Dr. Wright's approach is not just about treating the joint but about treating the whole person, and we love that.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

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Key Moments
“But also one of the “clinical knowns” of aging is the pillar of inflammation. Inflammation is one of the 12 pillars of aging. And as we accumulate enough birthday candles to set our kitchens on fire, our bodies deal with inflammation less and less well, and that just contributes to this picture of cartilage wear, which is arthritis.”

“Once you start wearing down your cartilage, it creates an inflammatory environment that we can measure in the joint fluid, which leads to more wear and tear and becomes a cycle. Before I go on with that, I want everybody listening to know that there are profound studies, however, that show that a lifetime of things like endurance running do not cause arthritis because you'll hear some very misled doctors say, ‘you better stop running and you're going to give yourself arthritis.’”

“How can you create an anti-inflammatory lifestyle? Number one, I want to de-inflame your whole body by cutting out simple sugars and wasteful, simple carb foods. Right? Our bodies are not trash compactors. It matters what you put in them, especially if you want to get out of inflammatory pain.”

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Today's SuperAge episode features author, pilot, and lifelong adventurer Caroline Paul, who shares her insights on the importance of outdoor adventure and its positive impacts as we age. Caroline emphasizes the significance of embracing new experiences, breaking through societal norms, and the unique empowerment that comes from stepping outside one's comfort zone. Her personal journey, highlighted by her various outdoor exploits, illustrates how engaging with nature can lead to a richer, more fulfilling life in one's later years. Caroline's message is clear: aging isn't about slowing down but about rediscovering oneself through adventure and exploration.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

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InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Fatty15: C15 is the first essential fatty acid to be discovered In 90 years. Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. Get 15% off their 90-day subscription Starter Kit here or enter code: AGEIST at checkout.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
“I used to be a whitewater rafter who did first descents with a team of women around the world. We did rivers that hadn't been done before and that kind of thing. I mean, it's cool to be first at things. When I was a firefighter, I wanted to be the first into the fire.”

“There are some [awe] triggers for awe. And one of them is just vastness.”

“Actually, turning your focus away from your self outward has been shown to be much better for your mental health. I'm not taking away from therapy or massages or anything, but it's worth saying that if we need to feel better, focusing outwardly is a valuable component of self-soothing.”

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Tough Broad Book
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Full Episode Transcript

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In this week's SuperAge podcast, we explore the inspiring journey of Shyla Michelle, a former trial attorney who channeled her personal struggles with sleep into a pioneering venture. Shyla shares her experiences with sleep difficulties, intensified by a high-stress legal career and hormonal changes, which led to the creation of Muslin Comfort. She delves into the unique properties of muslin fabric and how it aids in temperature regulation, offering relief not just for menopausal symptoms but for anyone seeking a better night's sleep. Shyla's story is a testament to how personal challenges can inspire innovative solutions, impacting lives beyond one's own.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

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Sundays: Sundays is healthy, fresh dog food made of human-grade ingredients that is easy to store and serve. No synthetic nutrients or artificial ingredients. Just good quality food for your pup. Get 40% off your first order here or enter code: AGEIST at checkout.

DIVI – take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

Key Moments
David:
Temperature regulation is not something that's talked about a lot, but honestly, it's no joke.

Shyla:
Well, I do think overall like to be more gender specific. I think it does affect women more. I mean, we get pregnant, we get birth. We have these huge hormonal fluctuations and then we're trying to work and we're trying to do it all. We're trying to be superwomen, right? Because that's what's expected in our modern world. And then our body, our nervous system is giving us clues that you're not okay.

"Honestly, isn't that what happens? Right? You become an A-hole. Because you're so irritable. You don't even have patience for yourself. Like, like how far does the lack of sleep go in terms of what's even happening with our world today?"

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Muslin Comfort
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In this week’s episode, we welcome Sune Lehmann, a network and complexity scientist at the Technical University of Denmark. Sune shares insights into his revolutionary work using algorithms to predict health outcomes, income, and mortality, drawing on extensive datasets from Danish citizens. He emphasizes the power of viewing human lives as sequences of events, akin to language, and how this perspective can lead to groundbreaking predictions about individuals' futures. We also get into the ethical considerations and future implications of this research, highlighting the balance between predictive accuracy and the importance of shared risk in insurance. Additionally, he touches on the once-Danish-now-global phenomenon of cold water swimming, illustrating how this practice offers a unique sense of well-being and mental clarity.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist

InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST

Key Moments
“From a certain perspective, human lives are sequences, right? You're born, you are seen by a doctor. They do some measurements and all of that information can be structured to create, let's say, the sentence of your life.

And so what we did is that we took an enormous dataset and we used the same technology that lies underneath the AI large language models, and we built a kind of general model for human lives.”

“That model, as long as you have training data, can really predict anything about humans. I mean, it might do things with kind of varying quality, but for the things that we've tested it, it performs better than any other algorithm that we can find.”

“So lots of people have kind of contacted me saying let's let's use this for something that's actually meaningful and useful. And I think, you know, what's amazing about what we do is that we also model not just the medical data, but the data around the life that people live.”

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Transcript

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In this week's episode, Dylan Livingston discusses his work with the Alliance for Longevity Initiatives, focusing on advocating for longevity science in the political arena. He emphasizes the importance of aligning with different political perspectives to promote the field's growth and the need for more foundational research and FDA support. Dylan also highlights the economic and health benefits of advancing longevity science and calls for public involvement in political advocacy to drive change in health policy and research funding.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
Fatty15: C15 is the first essential fatty acid to be discovered In 90 years. Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. Get 15% off their 90-day subscription Starter Kit here or enter code: AGEIST at checkout. 

Sundays: Sundays is healthy, fresh dog food made of human-grade ingredients that is easy to store and serve. No synthetic nutrients or artificial ingredients. Just good quality food for your pup. Get 40% off your first order here or enter code: AGEIST at checkout. 

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
“Alliance for Longevity Initiatives is a5001c for nonprofit organization focused on representing the longevity, biotech industry and general movement on Capitol Hill.”

“This is the next generation of health care. And, you know, it's their job as members of Congress to support and spread awareness around this topic and ultimately try to push more resources towards this effort.”

“You know, this is a major driver of economic growth. Right. I'm sure you have seen the longevity dividend argument, which, you know, the latest iteration argues, I think, $37 trillion in GDP gains for one extra healthy year of life expectancy–and even if that's off by, you know, 90%, that's still a, you know, $3.7 trillion is still worth pursuing.”

“So really right now, there are two or three major asks that I know will help the longevity industry and thus I believe, increase healthy lifespan in the U.S. First and foremost, there needs to be more foundational research for this space in geroscience in general from the federal government. I believe in 2023, 0.6% of the budget went to geroscience research at the NIH and aging is responsible for 70% of daily deaths. The second thing we want to get done is we want to help or really we want to help companies better design clinical trials through guidance from the FDA and support through congressional action. So those are the two big wishlist items you know, ultimately what we'd like to see in the long term, maybe medium long term, is a longevity initiatives bill.”

Connect with Dylan

Alliance for Longevity Initiatives

LinkedIn

Transcript

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This week, SuperAge explores the world of music and community with John Loken. John, an Executive VP of Marketing for The Recording Academy,  discusses his work with the GRAMMYs, highlighting their role in supporting and celebrating music creators. He emphasizes the academy's purpose-driven nature, focusing on advocacy, education, and crisis support beyond just the glitz of the GRAMMY Awards. John also gets into the power of music when it comes to creating a sense of tribe and belonging, transcending barriers of language, politics, and culture. His insights reveal the profound impact of music in unifying people and fostering a global community.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

DIVI – take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.

Key Moments
“Yes the GRAMMYs are a key part of what we do. That's what we're famous for. But the other 364 days a year, we are in Washington, D.C. advocating for creator rights. We are in schools helping to educate young people. We also have a Health and Human Services operation called MusicCares, which is not just about addiction support, but but really for people in any kind of crisis, economic crisis or otherwise”

“There's something about music and the way that music makes us feel that whether it is a classical artist, a jazz artist, a country artist, a hip hop artist, any EDM artist or rock artist, we're all in this music tribe, and it just really generates an incredible feeling of belonging.”

“We want to make sure we're talking about craft, right? There are plenty of award shows that are about the most streamed artists, or maybe the artists that sold the most tickets or had the most revenue off of their tours or whatever. That's not us. We're a different thing.”

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LinkedIn
The Recording Academy
Transcript

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In this week's episode of The SuperAge Show, Tamsen Fadal, renowned TV journalist and advocate for women's health, shares her insights on the importance of nurturing relationships and community involvement, particularly in later life stages. She discusses practical approaches to reduce social isolation, including reconnecting with old friends and participating in new groups. Tamsen highlights the role of vulnerability in forming genuine bonds and the effective use of digital platforms in cultivating meaningful connections. This episode offers valuable guidance for anyone looking to enhance their social network and create a supportive community environment.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
DIVI – take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
But I do think you have to get out there and put yourself out there, not be afraid, because you know what happens to all of us.

There is a place to go. There's something whether it's an activity or a hobby or whatever it is, there's something out there to go to, even no matter how big or small.

I realize now when I have a problem or I'm worried or fretting about something, there are those people that I can text or pick up the phone and talk to that make me feel like it's all going to be okay. And that's what that community is about. That's what that small community is about.

I watch my dad, who is 84. He goes to his gym, he meets people and goes out to restaurants by himself. He is determined to make sure he keeps doing that, even though a lot of his friends have passed away. And so I was like, Oh, he can do that. I should be doing that, because I think it's really, really hard and I think that sense of community is really necessary and really special. And I think that's kind of what we're all here for in the end.

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Podcast
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This week on the SuperAge podcast, we dive into the world of integrative and preventive medicine with Dr. Chris Renna. Dr. Renna, with a career spanning over three decades, shares his unique perspective on achieving optimal health and longevity. From discussing the nuances of detoxification and the role of the microbiome to exploring the future of biotech and AI in medicine, Dr. Renna provides a comprehensive look at modern healthcare techniques. He emphasizes the importance of individualized treatment plans and the integration of various modalities like nutrition, sleep, and exercise for overall well-being. The conversation challenges conventional medical thinking and a road map into the future of personal health management.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
“The Goldilocks concept is really the goal, but it is really complicated and highly individualized, meaning balance is quite subjective.”

“We're on the verge of developing generative A.I. Now we're considering both the risks and benefits of sentience, and I think that the way our brain works, we are naturally drawn to the risk before we're drawn to the opportunity. And I think that works, you know, like that's kept us here and that's brought us forward in our technologies.”

“If God had a complete understanding of every physiologic system and all of its implications and interactions, what would God recommend we have for supper? Generative A.I. holds that potential. It would only inform us. So I think that, you know, the future is amazingly bright.”

Connect with Dr. Chris Renna
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This week, we speak with Karl Pfleger, PhD who, after studying Machine Learning at Stanford and working a successful tech career, now does all he can to support longevity research and biotech. Karl discusses the inadequacies of traditional healthcare in addressing the root causes of aging and shares insights on groundbreaking research that can slow down or even reverse aging processes. He emphasizes the significant impact of lifestyle choices on longevity and previews promising future therapies, including stem cell treatments and mitochondrial health interventions.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

AmeriCorps Seniors — Get involved in your community through AmeriCorps Seniors’ volunteer opportunities and change your life. Go to AmeriCorps.gov/YourMoment 

Key Moments
“So the traditional health care and medical practice in our country, in the US and most of the world concerns really considering everyone to be baseline healthy until they get sick to a level where they're very sick and they cross some kind of a threshold for diagnosis of having an actual disease. So even though we call it health care, a lot of people kind of pejoratively describe it as sick care.”

“In short-lived species you can extend lifespans manyfold. One single gene mutation in worms can extend their lifespans by 10X, for example. And even in mice, we have interventions now that can extend their lifespans by 30% or 40% sometimes. And many of these interventions work across multiple species. So we believe they’re likely to work for people as well."

“I wanted them to realize how big [the longevity field] had gotten so that they wouldn't delay getting into it with more serious amounts of money. They didn't realize that they were two years behind given how fast it was growing.”

Connect with Karl Pfleger
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AgingBiotech.info
LinkedIn

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