Our first guest of 2024 is Dr. Darshan Shah, a surgeon, longevity expert, and founder of Next Health. In their conversion, David and Dr. Shah take a snapshot of today’s ever-changing health optimization and longevity landscape.The two discuss new diagnostic tools like executive physicals and AI-enabled heart scans, highlighting the power of early detection in combating conditions like Alzheimer’s, heart disease, and cancer. David also takes the opportunity to learn all about up-and-coming treatments like gene therapy from an expert. Dr. Shah also shares his personal journey from surgery to functional medicine, emphasizing the importance of looking beyond traditional Western healthcare to prevent chronic diseases.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

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Key Moments
“I think there's a lot going on in the world of longevity that unfortunately the FDA is trying to block. But you know, the research continues to go on in other countries and it will continue to flourish and we will be able to do a lot of these things here at some point, whether it be in the United States or outside.”

“I always tell people that we have a few different goals in mind. Our first goal is to optimize along the most common things we need to make sure your nutrition, your exercise and your sleep is perfect, right? And so as close to perfect as we can get it.”

“If Steve Jobs were alive today, and he had an executive physical, he would have been saved from pancreatic cancer."

“I always tell my patients, you need to know what your hemoglobin A1C level is. I should ask you, and you should be able to tell me what it is.”

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Next Health
Making the Cut: 10 Things You Should Consider Before Having Plastic Surgery
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This week, we discuss the importance of setting realistic and sustainable goals. If we can form positive, long-term habits rather than resorting to extreme, short-term “resolutions,” we can get more healthy every day. Reflecting on previous goals, David shares personal anecdotes and lessons learned. Why not take a gradual approach to fitness and nutrition that aligns with one's lifestyle and capabilities? The episode is a blend of practical advice and motivational insights aimed at fostering a healthier, more self-aware approach to personal growth and well-being.

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Key Moments
“When people think about goals for the new year, they often initially think about things like diets and exercise, fitness, these sort of things. What I have seen, I've seen this multiple times. I have engaged in this myself and I can tell you it does not work.”

“We're looking to establish habits, habits that we can keep for a long period of time. Extreme diets are not a habit. They're sort of a short term occasion, and just a recipe for failure. We want to slightly modify what we're doing so that we can achieve it, so we can pat ourselves on the back and say “great job, reevaluate in three months.”

“So this is an achievable target and it's measurable, which is really key about this.”

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This week, we host James Whittaker, entrepreneur and bestselling author of Think and Grow Rich: The Legacy and Andrew Carnegie’s Mental Dynamite. James turned his struggle with anxiety into a journey of self-discovery and success. James highlights his 'WIN method' - Wonder, Intent, Nurture - as a framework for purposeful living and defining success on a personal basis. Emphasizing self-awareness and resilience, James aligns perfectly with SuperAge’s vision of meaningful growth.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
“It's better to be green and growing than ripe and rotting. Like just because you've had a few wins and adventures in your past doesn't mean that you need to hang up your hat.”

“The longer we're in an environment where we're by ourselves, that's where this stuff gets really, really dangerous because we simply lose track of what's possible. So we retreat to autopilot, which works on the condition that you're very intentional with it. If you're not intentional and you don't have a process of getting around really high-level thinkers on a consistent basis, then you need to be conscious that that autopilot is going to eventually work against you”

“It's really important to think about what season of life you're in and what is the metric for you to determine whether or not you're making the right progress. And sometimes just simply being on the right journey is enough. It doesn't matter about some of these other things that may or may not have manifested, just simply being on the right path and being aware of what's around you and putting one foot in front of the other, knowing that the universe is working for you.”

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In this week’s episode of SuperAge, Dr. David Spiegel, who, after receiving a PhD in medicine from Harvard, went on to become a renowned expert in hypnosis, dissociative disorder, PTSD, as well as a Stanford professor. He has also authored many books over the course of his 40-year career, including Living Beyond Limits: A New Hope and Help For Facing Life-Threatening Illness. In our conversation, Dr. Spiegel shares his insights on harnessing the power of the mind for healing and wellness. Drawing from experience, Dr. Spiegel discusses the significant impact of hypnosis in managing pain, stress, and anxiety, especially in cancer patients. He illustrates how self-hypnosis can be a vital tool for emotional and physical wellbeing and provides fascinating stories about its effectiveness. This episode offers a unique perspective on research-backed alternative healing methods, emphasizing the untapped potential of the human mind in health and recovery.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

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Science Research Wellness — improve your cellular health. Listeners receive 20% off all products with code AGEIST20 at SRW.co.

Key Moments
“We started out helping people to stop smoking and we found that one out of five people just stopped smoking using the [Reveri] app right away. So that's about as good as I get when people are sitting in my office and I'm doing it. And it's about as good as you get using varenicline or bupropion or nicotine patches as an alternative.”

“They learned to control their pain with self-hypnosis so that a new pain in their chest didn't automatically mean to them that their disease was progressing. It meant they needed to do something to control the pain. And they did. So they had half the pain. And in our original study that we published in The Lancet, we found that the women randomized to work groups actually live longer than the control patients by an average of a year and a half.”

“We found actually that people with breast cancer who were inefficient sleepers, who had trouble getting to sleep or staying asleep, actually also had shorter survival. But the other way around is that good sleepers live longer. It was having a long period of good 7 hours of consistent sleep at night, predicted with fewer disruptions, predicted longer survival with breast cancer.”

“After a deep inhale, a slow exhale is important. And part of why it is is, you know, we're used to saying, you know, if you're anxious or tense, take a deep breath. Well, actually, the inhale actually tends to increase sympathetic activity because it reduces venous return or blood to the heart. If you think about it, you're lowering pressure in the chest.”

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Reveri App: Support someone who supports you this holiday season. To gift a 1 year subscription of Reveri to someone you care about, simply head over to

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In this show, we learn that incredibly high powered AI is now being used in human nutraceutical research, specially targeting the 9 hallmarks of aging. Our guest Greg Macpherson, CEO of SRW Labs in New Zealand, joins us this week to share all about how automated labs are making unprecedented progress in identifying and creating compounds that may solve human longevity. By automating many of the tedious testing and refinement processes, AI labs are able to work with extreme efficiency, which translates to bringing meaningful longevity products to the public with extraordinary speed. We are very excited to learn about this from Greg, and to hear that we could be expecting to see some new targeted products hitting the market by summer 2024.

What kind of SuperAger are you? Take the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Don’t forget to watch this week’s episode of “Since You Asked” a new Q&A show from AGEIST. 

Thanks to our sponsors:
InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments
“So we are going to get to a stage where we get to have a DNA test before we start taking medicine and you know there may be 10 drugs on the shelf that are appropriate for whatever condition that's being treated and they'll select the one that's best for you. But also they'll be able to look at it and go, okay, look, there's a high chance, given your genetic makeup, that these are going to be a problem.”

“There are animals out there that live for 200 years like the bowhead whale. They are mammals just like us, so there's no reason that we can't learn from whatever genetic hacks that they've got which mean that they live longer. And then, of course, the Greenland shark lives for 500 years. So these are animals. We can learn from them, and once we do, then all bets are off as to what kind of longevity we're going to see.

“Of course it's not the longevity that we think of today. We're going to be talking about bodies aged 30 to 40 and having those bodies for 200 years, which is a little outside a frame of reference right now. But future humans are going to go ‘golly, those poor people back then who only got to live for 80 years and only 40 years in good health.’”

“In 3-5 years, there will be a product to slow or stop the aging clock”

“You know, unfortunately, sugar is cheap and it's tasty and it's nice and we all love it. So there's just a huge industry around it, but it's not serving us well, and now we understand that, just like we went through taxing tobacco, maybe we've got to do the same just to nudge the population away from it and educate people how bad it is for us.”

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We are very excited to have sports and performance psychologist Dr. Lauren Loberg on the show this week to ruminate on the intersection of everyday life and this idea of a “performance mindset.” Everyone wants to do their best, and using insights from working with the world’s top athletes (think: NFL stars and pro skiers like Mikaela Shiffrin), Dr. Loberg shares her tips on how we can implement high performance mental strategies into our daily lives. Together, we discuss anxiety, flow state, and the value of mental preparedness.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Don’t forget to watch this week’s episode of “Since You Asked” a new Q&A show from AGEIST

Thanks to our sponsors:

InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

DIVI – Take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.

Key Moments
“If someone comes to you and says I want to be fit this summer, what does that mean? What exactly does that mean? Or ‘I want to be more present.’ Well, what does that mean for you? What does that look like? Like, what's the action? Because when people provide us with these really arbitrary things and sometimes they do, they can keep judging themselves on it because there's no measurement to it. Does that make sense?”

“I think that everyone can be mentally tough, but it's also a thing that takes time. Remember that some of the things you struggle with mentally, might stem from a pattern that you've had for 50 years. Putting this in the context of sports, if you tried to change your golf swing or basketball shot after 50 years of playing, would you be able to fix it in five tries? No. The same goes for mental toughness.”

“You can kind of learn how to embrace fear, the fear of when it becomes paralyzing. That's the part that you have to talk through.”

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Pyramid Performance
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Is it possible to build muscle without lifting weights? Can we tone our facial muscles? Is it possible to improve our cardiovascular system with almost no effort? Today, we sit down with former USA swim coach and Kaatsu CEO Steven Munatones. He tells us all about his decades-long journey of discovery and tutelage under Dr. Yoshiaki Sato in Tokyo, wherein he studied the myriad benefits of Japanese Kaatsu bands and developed a plan to introduce this technology to the world. Huge amounts of research out of Japan are showing that one can maintain strength and vitality as they age, improve overall vascular function, rehabilitate injuries all with zero risk of injury.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

Key Moments
“Why would someone [restrict blood flow]? They do it for a variety of reasons, and there's a lot of literature out there by researchers, scientists, physicians, and physical therapists, and you want to do this mostly to build muscle. Building muscle helps if you're injured, maybe you had a surgery on your knee, maybe you broke your arm. It helps reduce atrophy. And so part of the recovery process is rebuilding that muscle loss. When you use BFR, you actually reduce the amount of muscle atrophy that you get, so your body will heal itself and then you go through a shorter recovery period because you're not losing as much muscle mass.”

“Fundamentally, what's happening is a bit of hypoxia or lack of oxygen in the muscle. If you do movement as simple as bicep curls. It could be stretching, it can be walking, whatever you want to do that leads to that uncomfortable feeling you have when you work out. That lactate sends a signal through your central nervous system up to your brain. And then the brain thinks that you are doing something very vigorous, something very intense. And when the brain receives that signal again, the brain does not know if you're lifting heavy weight or you're just doing BFR. So it reacts as it naturally does and produces growth hormones amongst other metabolites, which flow through our vascular system and promote muscle growth”

“The Japanese found that when you engorged the limbs and blood and you do slight movement, this is the most effective way to trigger those signals up to the brain and then release a variety of hormones.”

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This week, we host Chris McDougall, runner, reporter, and author of Born to Run, on the show to discuss his wide-ranging life experience. His concept of the hero is that they are responsible for others, that we humans are designed to be cooperative, that we are at our best when we are thoughtful and caring. In it all, it is important that we seek out fun. From learning from Mexico’s Rarámuri ultrarunners, to training a mistreated donkey to join him in competing in the 29-mile Pack Burro race in the Rockies, Chris’ life has been anything but average. Now living on Oahu, Hawaii, the 61 year-old continues to push himself to uncover stories, pick up new hobbies, and reflect on how his past informs his present day outlook on health, wellness, and keys to longevity.

What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)

Thanks to our sponsors:
InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

SRW Labs – Science Research Wellness — improve your cellular health. Listeners receive 20% of all products with code AGEIST20 at SRW.co.

DIVI – Take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.

Key Moments
“I think what bothers me the most–and this applies in every aspect of our lives–is this sad human arrogance that we can outthink two million years of evolution. Natural selection has created this unbelievably complex self-healing device.”

“I spent a lot of time on the Greek island of Crete looking at World War II resistance fighters. Crete was one place that had a sensational story about average citizens who rose up to resist the German occupation. Again, these are not trained soldiers, these are just citizens who overnight, literally from one week to the next, went from being citizens into being military operatives against the most formidable army on the planet. And so my question was well, how do you do that physically? How do you turn yourself into a super soldier? And one of the things I looked at was diet.”

“You know one thing when you look at the human animal, there are two things that we are really good at. We are extraordinarily adaptive–we're very creative and ingenious. But secondly, we're extraordinarily cooperative. What is the internet all about? It's about trading stuff, trading images, trading thoughts, trading ideas. We are probably the most cooperative animal on the planet and we tend to forget that sometimes because, particularly in America and particularly in this era in America, we've come across this very sad notion. You know you gotta be tough. You know you gotta close the borders, you gotta be strong, you gotta crush this guy, you gotta win, win, win. That's not who human animals are. You know human animals throughout history have coexisted and have shared and cooperated. And if you look at most ancestral cultures, they were not about accumulation and acquisition and conquering. They were about coexistence, cooperation and learning from each other.“

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Born to Run
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What are the actions we can take to maintain our long-term brain health? This week, we discuss this and more with Dr. Marc Milstein, author of The Age-Proof Brain. It turns out that even small behavioral changes, such as eating less processed foods and regularly challenging yourself with activities like playing an instrument will support overall brain fitness and neuroplasticity. Furthermore, Dr. Marc also breaks down the surprising link between gut and brain health. 

What kind of SuperAger are you? Take our quiz today and find out! Visit: ageist.com/quiz


Thank you to our sponsors: 

Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. 

InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

Key Moments:

“Anything that is processed is likely to feed bad bacteria. These bacteria have been around much longer than us, and so the things that they like to eat are the things that were around much longer than us, long before we got here, and the bad bacteria tend to feed on the things that we created.”

“There's definitely foods that are great for brain health, but it's really about variety and we really have evidence that it's a synergistic relationship. It's not one food item that is just like this brain-boosting magic food. It's how the foods work together and that's why we believe that supplements can be beneficial, but they're not in many cases as beneficial as dietary changes, because what's in the food works together with other nutrients.”

“So what we see is that it's not about this stress-free lifestyle. Our brain is like a car, I like to say, and if you don't drive it, it falls apart, and if you over drive it, it falls apart. Stress is a burst of cortisol. Say I want to get something done. There's a challenge, I want to tackle something. All those moments of stress are actually good for our brain because they release cortisol and there's a part of our brain called the hippocampus which is really important for memory, and a squirt of cortisol in a moment of stress actually helps the hippocampus stay strong.”

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The Age-Proof Brain

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This week, we chat with Dr. Rich Joseph, the Chief Medical Officer at Restore Hyper Wellness, founder of vim Medicine, and co-founder of Vital CxNs. David made ample use of the Restore facilities during his recovery from knee surgery, and we like how their business helps to make treatments like hyperbaric oxygen therapy, red light therapy, IV drips, and others accessible to the public. During our conversation, Rich shares his view on the literature supporting up-and-coming therapy treatments, the importance of challenging oneself at any age, biomarkers, and his nonprofit work with underserved populations in Boston. 

What kind of SuperAger are you? Take our quiz today and find out! Visit: ageist.com/quiz

Thank you to our sponsors: 

DIVI – Take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.

InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.

LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.

“My whole background is walking this fine line between the traditional medical system and the wellness industry. I was a personal trainer for a long time and that was my first foray into health and wellness before becoming a doctor. Now I help bridge the gap between these two sides. I think we have to be humble, the more I learn, the less I know about this stuff. Human health and our biology is very complicated, and yet there’s unfortunately still this imperative to like, make claims and to be bold in order to get people's attention.”

“This stuff is nuanced and we hope that people who really take their health seriously also have the responsibility of helping to advance the data and dig into the science.”

“How do you push the body into stress right in a way that's adaptive for the body? And that's what cold therapy does, it's what heat therapy does. This is sort of “perturbing” our homeostasis so that the body becomes more adaptive over time, and is able to better regulate itself.”

“Entropy is working on us all the time and so you have to push back against that and that's uncomfortable. That means welcoming and inviting discomfort into your life and to your day and that, to your point, is sort of against everything that we're sold right now and what we're taught to believe is best.”

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Restore Hyper Wellness

vim Performance Medicine

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