Chris Duffin sits down with legendary molecular biologist and endurance athlete Dr. Bill Andrews, a man who truly walks the walk when it comes to resilience.

In this episode, we explore Dr. Bill Andrews's remarkable pursuits as an ultramarathon runner—including competing in grueling events like the Death Valley Badwater 135 and high-altitude races in the Himalayas, defying what most believe possible for a 70-plus-year-old. Beyond his athletic feats, Dr. Bill Andrews shares his groundbreaking work on the human telomerase gene—an innovation that reshaped how we understand aging at the cellular level.

Dr. Bill Andrews doesn't just share science—he gives you actionable ways to slow down cellular aging and protect your longevity:

• The impact of lifestyle choices (yes, he discusses alcohol, stress, diet, and even meditation)
• Nature's defenses: antioxidants, anti-inflammatories, and a sneak peek into cutting-edge nutraceuticals like Telovital
• Debunking myths around anti-aging products and the best, science-backed tests to measure your cellular age

Dive deeper! Learn more about Dr. Bill Andrews, his quest for immortality, and his favorite anti-aging supplements at Sierra Sciences: https://sierrasci.com/dr-bill-andrews/

💡 RT if you want to live to 125+ and beat Father Time! 👇 #Longevity #Biohacking #Science #UltraRunning #AgingReversed

Contents:

00:00 Himalayan Ultra Race Achievement

07:58 "Telomeres and Aging Discovery Journey"

15:52 "Alcohol, Aging, and Cell Division"

16:55 "Telomerase: Protection Against Aging & Cancer"

23:19 "Telomere Shortening: Key to Aging"

30:00 "Explore Chris Duffin's Ventures"

36:59 "Telomerase Activity: Key Questions"

38:57 "Telovidal: Advancing Anti-Aging Science"

48:51 "Unveiling Telomere Activation Mechanism"

52:17 "Critically Short Telomeres Explained"

59:58 Lifestyle Choices Impacting Telomere Health

01:05:07 "Telomere Shortening and Telovidyl"

01:08:33 "Evaluating Touchstone Essentials Products"

01:12:03 "Contact [email protected]"

Learn & Connect at https://chrisduffin.com/

• SHOP: Explore my books and products in the store.

• EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.

Dr. Dwayne Jackson—a powerhouse in the world of performance, resilience, and peptide science. With decades of experience from pro motocross and bodybuilding to scientific research and personal health transformation, Dr. Jackson shares how his pursuit of peak performance shaped his journey, from building race cars with his family to pioneering new approaches to athletic recovery and executive wellness.

Together, Chris and Dr. Jackson explore the parallels between elite athletes and high-performing professionals, diving deep into blood work, inflammation, mitochondrial health, and optimizing hormones. Expect practical insights into peptide usage, the importance of setting up the right physiological "terrain," and a close look at recovery tools like exogenous ketones and breakthrough mitochondrial peptides.

Listen to the episode for:

• Actionable tips if you're navigating the aftermath of years of hard training, stress, or PEDs.

• Effective peptide protocols for sleep and recovery (e.g., CJC 1295, Ipamorelin)

• The role of exercise and proper timing of hormone/peptide use

Check out Dr. Dwayne Jackson: vitalitymanifesto.com

On Instagram @drdnjackson for daily insights

His upcoming Vitality Manifesto podcast: http://www.youtube.com/@vitalitymanifesto

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by:

Enhanced Executive Peptides: https://shop.enhancedexecutive.com

00:00 Bodybuilding, Motocross, and Recovery

09:40 Athlete Health Decline in Mid-30s

12:40 Inflammation, Glucose, Insulin: A Trifecta

22:05 "Health First, Peptides Second"

29:52 "Optimizing Hormones with Natural Rhythms"

35:06 Steroid Dosing and Side Effects

41:18 Estrogen's Role in Male Hormones

47:22 Oxidative Stress and Endothelial Health

50:37 Mitochondrial Enhancers for Performance

01:05:13 "Ketones for Recovery and Sleep"

01:07:49 "Ketone Absorption Timing Explained"

01:13:15 Mitochondrial Health & HIT Training

01:18:18 Achilles Mobility and Training Reflections

Drop your most surprising lesson from this thread or your peptide questions in replies!

#Resilience #PerformanceScience #PeptideTherapy #Longevity #Biohacking #Podcasts

Learn & Connect at https://chrisduffin.com/

• SHOP: Explore my books and products in the store.

• EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.

Chris Duffin sits down with Bizzie Gold, creator of the Break Method and author of "The Mind is a Filthy Liar," for a deep dive into the power of subconscious coding and emotional rewiring. If you've ever wondered why high achievers can succeed outwardly while struggling internally, or how to get unstuck from self-sabotaging patterns, this episode brings the answers.

Bizzie Gold shares her unique, data-driven approach to identifying and breaking self-deceptive mental habits—going well beyond traditional therapy. She opens up about her own transformative journey, growing up in a household shaped by mental health challenges, and how a chance encounter with mushrooms and the movie Fight Club at 13 reshaped her worldview.

💡 Big Takeaway: "Growth is the name of the game. Oppose your own patterns & find where discomfort can build real resilience." – Bizzie Gold

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by:

Enhanced Executive Peptides: https://shop.enhancedexecutive.com

Learn more about Bizzie Gold: https://www.bizzie.gold

• Explanation of the nine marker framework
• Brain pattern diagnostic session (how it works, timeline)
• Perception of reality as a foundational marker
• Emotional addiction cycle and behavioral cycles
• How these patterns function as a system

#Resilience #MentalHealth #Leadership #PodcastTakeaways #PersonalGrowth

00:00 "Rewiring the Mind with Busy"

05:14 "Break Method: Clear Self Insight"

13:50 "Lightning, Innovation, and Perception"

18:04 "From Inspiration to Breakthrough Method"

26:00 Left vs Right Brain Patterns

31:14 "Prioritizing Non-Negotiables in Life"

32:14 Balancing Work, Family, and Focus

37:56 "Embracing Balance and Wellness"

43:56 "Resilience: Commitment, Grit, Self-Trust"

50:36 "Teaching Honesty Through Soccer"

55:24 "Transformative Effects of Tirzepatide"

01:00:14 "Thriving Beyond 2000 Calories"

earn & Connect at https://chrisduffin.com/

• SHOP: Explore my books and products in the store.

• EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.

Today, we're excited to dive deep into the science and strategy of healing, aging, and true resilience with Natalie Nidham—a renowned peptide and bioregulator expert, host of the Longevity with Natalie Nidham podcast, and founder of one of the world's largest peptide communities.

In this conversation, Chris Duffin sits down with Natalie to explore her journey from holistic nutrition to becoming a trusted leader in the world of cellular optimization and biohacking. With her uniquely grounded, systems-based approach, Natalie shares why building real resilience starts from the inside out—and why peptides are only one piece of the puzzle.

Learn more about Nathalie's work here: https://www.natniddam.com

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by:

Enhanced Executive Peptides: https://shop.enhancedexecutive.com

🔹 Lifestyle is the Foundation Peptides and supplements are powerful, but real, lasting change begins with the basics: sleep, nutrition, stress management, and movement. Without a strong foundation, high-level interventions just won't stick.

🔹 Peptides as Strategic Support, Not a Cure-All Used wisely, peptides can accelerate healing and provide "quick wins" when someone's struggling to get traction—but they should be paired with foundational changes, not used as shortcuts.

🔹 Test, Observe, Adapt Data from wearables like the Oura Ring and continuous glucose monitors can reveal trends, but it's the long-term patterns—not single-night stats—that matter. Effective protocols are built on critical thinking, ongoing feedback, and personalization.

00:00 "Resilience and Peptide Science"

08:53 Critical Thinking in Healing

12:28 "Building a Solid Foundation"

17:05 Cell Health for Optimal Function

22:32 Mitochondrial Optimization Strategies

27:46 Tracking Trends in Health Metrics

42:16 "Bioregulators: Repairing Epigenetic Errors"

42:52 Histones, Ketones, and Synergy

49:33 Bioregulators: Limits and Potential

59:22 "Mother Nature's Playbook Explained"

Learn & Connect at https://chrisduffin.com/

• SHOP: Explore my books and products in the store.

• EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.

We're bringing you a powerhouse episode this week! In Episode 35 of the Architect of Resilience Podcast, co-hosts Chris Duffin and Anthony Castor sit down with the legendary Eric Serrano for a deep-dive conversation that bridges cellular health, hydration, hormones, and the foundations of well-being.

We dive deep into the foundations of resilient health—including hormone optimization, cellular hydration, nutrition, and the art of overcoming life's challenges. Eric Serrano shares hard-won wisdom from decades serving athletes, bodybuilders, and practitioners worldwide. He opens up about the values that define him beyond accolades: being a great father, husband, mentor, and friend.

Also, officially welcoming Anthony Castor as ongoing co-host! His expertise in cellular medicine means every episode will now have an extra layer of insightful questioning and analysis.

Check Eric out: https://www.eliteftsswis2022.com/dr-eric-serrano

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by:

Enhanced Executive Peptides: https://shop.enhancedexecutive.com

Contents:

00:00 "Transformer Bar Praise"

09:51 "Cellular vs. Blood Hydration"

11:06 Optimal Hydration and Osmolytes

17:34 "ATP, Magnesium, and Cellular Energy"

31:18 Histones, Methylation, and Histamine

36:53 "Vitamin D Myths Explained"

40:40 Seasonal Vitamin D & Melatonin

43:49 "Low Testosterone and Cholesterol Insights"

51:58 "GLA and Skin Health Insights"

56:48 C15, Methylene Blue, Oxidation Insights

01:00:58 "Debunking Breakfast Myths"

01:05:23 "Paleolithic Habits and Health"

01:21:25 "SOD Gummies Boost Health"

01:25:55 Conclusion

Learn & Connect at https://chrisduffin.com/

• SHOP: Explore my books and products in the store.

• EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.

Chris sits down with Jessica MacNaughton, CEO and co-founder of C60 Power, and a pioneering voice in health innovation and mitochondrial resilience. After a personal health crisis shifted her path from commercial real estate to holistic wellness, Jessica became a passionate advocate for Carbon 60—a Nobel Prize-winning molecule shown to support energy, cellular health, and longevity.

Chris and Jessica dive deep into the science behind C60, exploring its powerful antioxidant properties, impact on inflammation, hormone regulation, and even cognitive function. From elite athletes recovering faster, to everyday people regaining energy and focus, Jessica shares compelling stories and personal transformations tied to this molecule. The conversation also unpacks the importance of quality supplementation, the potential for C60 to support pets and the future promise of this unique compound in vibrant aging and resilience.

Try C60 for 10% off

https://go.shopc60.com/ZM5BLQ/KMKS9/

If you want to dive deeper, check out WhatIsC60.org for research or explore the C60 Power line at ShopC60.com.

#Resilience #Biohacking #Wellness #Longevity #Mitochondria #PodcastInsights

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by:

@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin

@buildfastformula : Build Smart. Build Strong. Build Fast. 💪🏼🧬 Use code RESILIENCE for 10% off your order at https://buildfastformula.com

Contents:

00:00 C60: Anti-Aging Antioxidant Revolution

06:17 "Biohacking and Supplement Guidance"

09:45 "C60: Recovery and Performance Boost"

12:12 C60: Boosting Cellular Health

16:41 "Histamine, Peptides, and Aging"

18:47 Peptides, C60, and Experts

24:07 C60: Healing and Lifestyle Synergy

31:04 "Transparency and Research Matter"

34:02 "C60 Doubled Rat Lifespan"

36:57 "Ketones, Coffee, Pathway Synergies"

44:26 Neuroprotection and Mitochondrial Support

49:08 C60 Skin Care for Sun

Learn & Connect at https://chrisduffin.com/

• SHOP: Explore my books and products in the store.

• EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.

Chris Duffin sits down with Dylan Gemelli—a trailblazing voice in biohacking, health optimization, and performance enhancement. Dylan's story is one of raw resilience: from his early days as a multi-sport athlete and personal trainer, through adversity and personal transformation after serving time in prison, to becoming a respected digital health influencer and top-ranked podcaster.

Together, Chris and Dylan dive deep into what true strength and resilience mean, exploring how adversity and personal accountability shape lasting success. Dylan shares how his time in prison was a powerful catalyst for growth, driving him to focus on giving back and challenging the norms of the health and wellness industry. They discuss the paradigm shift from steroids and traditional performance enhancers to the groundbreaking world of peptides, cellular medicine, and biohacking—with frank insights on avoiding industry pitfalls and building authentic health from the ground up.

Check out Dylan: https://dylangemelli.com

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by

@bearfootshoes : The Original Barefoot Lifting Shoe 🐻🦶🏼 Use code RESILIENCE for 10% off your order at https://www.bearfoot.store

@buildfastformula : Build Smart. Build Strong. Build Fast. 💪🏼🧬 Use code RESILIENCE for 10% off your order at https://buildfastformula.com

Key Takeaways:

• Resilience Means Refusing to Settle: Dylan defines resilience as the ability to bounce back and relentlessly pursue solutions—never accepting "no" or mediocrity, no matter the challenge.

• Cellular Health is Foundational: From diet and stress management to leveraging peptides and biohacking tools, Dylan highlights how true optimization starts with the basics—fixing your mitochondria and gut is where disease prevention begins.

• Accountability Drives Transformation: An honest reflection on his own setbacks revealed the importance of considering others in your choices, being open to change, and using adversity as fuel for your mission.

Learn & Connect at https://chrisduffin.com/

• SHOP: Explore my books and products in the store.

• EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.

Chris Duffin sits down with Anthony Castore to dig into the buzz surrounding methylene blue—dubbed by some as a miracle for boosting mitochondrial efficiency and ATP production. But is it really the game-changer it's hyped up to be? Together, Chris and Anthony break down what methylene blue is, why people are jumping on the bandwagon, and crucially, why they aren't recommending it for everyday use.

From mitochondrial function and the importance of nitric oxide in everything from heart health to brain power (and yes, even erections), to alternative ways of optimizing your body's resilience, this episode is all about cutting through the hype and focusing on what really works for strength and long-term health. Tune in as they share practical insights, expert-backed alternatives, and a dose of real talk about supplements and strategies to help you maximize your longevity and vitality.

Optimize with Other Proven Methods: Strategies like red light therapy, NAD+ restoration, and compounds such as CoQ10 or GHK-Cu often deliver benefits without the side effects—helping you build resilience and physical health, safely.

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by:

@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin

@buildfastformula : Build Smart. Build Strong. Build Fast. 💪🏼🧬 Use code RESILIENCE for 10% off your order at https://buildfastformula.com

Contents:

00:00 Methylene Blue and Nitric Oxide

05:34 "Mitochondrial Boost Post-Covid"

08:21 Restoring NAD Pathways in COVID Treatment

10:21 Optimize Mitochondrial Function Tools

Learn & Connect at https://chrisduffin.com/

• SHOP: Explore my books and products in the store.

• EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.

Chris Duffin sits down with world-renowned hybrid athlete, elite performance coach, and bestselling author, Kris Gethin. Known for redefining boundaries in fitness—from professional bodybuilding to Ironman triathlons and ultra-marathons—Kris has become a leading voice in the world of health optimization, biohacking, and longevity.

Chris and Kris dive deep into topics ranging from overcoming self-doubt and societal expectations, building resilience through discipline, navigating the world of peptides and biohacking, and the evolving landscape of fitness—from chasing aesthetics to prioritizing healthspan and longevity. Kris also discusses the mission behind his new supplement line, Unmatched, aimed at bridging the gap between performance and well-being without sacrificing long-term health.

8/ High performers want quick fixes (double the supplements, peptides, biohacks). Kris's advice? 🔑 1. Fix your sleep 🔑 2. Ditch your phone 🔑 3. Get out into nature 🔑 4. Do hard stuff daily (cold plunge, early rises) Supplements? Only AFTER you master the fundamentals.

Check out Kris: https://www.krisgethin.com

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by

@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin

@bearfootshoes : The Original Barefoot Lifting Shoe 🐻🦶🏼 Use code RESILIENCE for 10% off your order at https://www.bearfoot.store

Learn & Connect at https://chrisduffin.com/

• SHOP: Explore my books and products in the store.

• EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.

Contents:

00:00 Living Present, Achieving Unplanned Success

07:00 Balancing Fitness Goals and Recovery

14:52 "Morning Ice Baths for Mental Stability"

16:40 "Peptides: Misused by Biohackers?"

24:51 Peptides and Lifestyle for Hormonal Health

27:30 "Test First, Don't Guess"

34:37 Peptide Sensitivity Varies Widely

37:48 Longevity vs. Performance in Supplements

42:57 Expanding Ambassador Program for Growth

52:00 Career Challenges and Immigration Struggles

56:18 "Push Limits, Build Resilience"

01:00:07 Choosing Personal Failures Over Riches

In this episode, host Chris Duffin sits down with the legendary Clark Bartram—Marine veteran, National Fitness Hall of Fame inductee, and founder of the Maximized Man Elite program. Known as America's most trusted fitness professional, Clark has dedicated his life to inspiring men to reclaim their vitality, strength, and purpose—naturally and sustainably.

Clark Bartram's journey in men's health and fitness is nothing short of remarkable. Once a U.S. Marine, Clark transformed his discipline and passion into a decades-spanning career—earning recognition as "America's most trusted fitness professional." He's inspired millions through books, TV appearances, and elite coaching, notably with his Maximized Man Elite program, guiding men over 40 to reclaim vitality and strength naturally.

At age 61, Clark faced a new test: a diagnosis of prostate cancer despite his peak condition. Rather than let it stop him, Clark became an advocate, founding the nonprofit "Check It Like a Man" to promote early screening and awareness.

Clark Bartram: https://clarkbartramsystems.com

Instagram: @clarkbartram

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by:

@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin

@buildfastformula : Build Smart. Build Strong. Build Fast. 💪🏼🧬 Use code RESILIENCE for 10% off your order at https://buildfastformula.com

Contents:

00:00 "Embrace Each Day's Opportunities"

06:45 Marine Corps: Building Strength and Discipline

14:07 "Maximizing Strength with Build Fast"

20:53 "Get Off the Dance Floor"

22:44 "Step Back for Self-Reflection"

30:12 "Appearance and Respect: A Life Lesson"

37:22 Lifestyle Change Essential for Hormone Health

42:53 Integrity's Impact on Life and Health

48:24 Driven by Testosterone Ambitions

52:22 Testosterone Therapy and Advocacy

55:55 "Men: Slow Down After Diagnosis"

01:00:05 "Set, Setting, and Connection"

🔹 Strength isn't just physical. Clark reminds us that real strength is about showing up for the challenges life throws at us—whether it's in our relationships, at work, or for ourselves. Physical strength is just one facet; emotional and mental resilience are equally critical.

🔹 Radical responsibility and boundaries. One of Clark's non-negotiables: setting clear boundaries to protect your energy. He shared how defining personal limits—even with loved ones—can be a game-changer for maintaining your focus and resilience.

🔹 Natural optimization beats quick fixes. Clark is a strong advocate against the trend of "quick-fix" testosterone therapies, urging men to focus on mindset, community, and lifestyle—like proper nutrition, movement, and integrity—before turning to medical interventions.

Learn & Connect at https://chrisduffin.com/

• SHOP: Explore my books and products in the store.

• EDUCATE: Unlock access to my incredible Education Portal featuring hundreds of hours of courses and thousands of guided movement videos, all conveniently indexed for easy navigation.

Plus, dive into a wealth of articles on supplements, peptides, and training.

• CONNECT: Join my FREE community to engage with like-minded individuals. Don't miss out on these valuable resources—visit now and take your performance to the next evolution… the Endless Evolution!