The Drug Landscape Has Changed—Are You Ready? Australia is now facing one of the deadliest evolutions in synthetic opioids—nitazenes. With potency levels up to 20 times higher than fentanyl, these hidden killers are showing up in fake pills, club drugs, and even "safe" prescriptions. Most users don’t even know they’ve taken them… until it’s too late.In this week’s Cracking Addiction episode, Dr. Fergal Armstrong dives deep into the pharmacology, clinical signs, and harm reduction strategies practitioners need to know—plus, why current toxicology screens are leaving clinicians in the dark.