What if the fastest way to improve your brain isn’t just one treatment but three powerful levers working together to reverse cognitive decline? In this episode, I interview Dr. Nick Delgado, a pioneer in hormone optimization, inflammation control, peptide therapy, and lifestyle medicine, to explore what he calls the fastest levers for transforming brain health. We break down how nutrition, hormone balance, and targeted peptides can rapidly shift cognition, reduce inflammation, and support the aging brain. 

Dr. Delgado shares stories from over 45 years of clinical experience, including remarkable cases of patients with advanced Alzheimer’s who showed unexpected improvements after strategic interventions. We discuss the roles of triglycerides, dietary fat, cholesterol, and plant-based nutrition in maintaining blood flow to the brain. 

We also dive into hormone restoration–testosterone, DHEA, pregnenolone, estriol, progesterone–and how these influence cognition, mood, and neuroprotection. Dr. Delgado explains how each tool can support brain regeneration when used thoughtfully and synergistically. 

“Alzheimer's and cognition and so forth, is not only a hormonal decline. It's an arterial problem, it's a lack of circulation, so you want to figure out every way to bring massive amounts of blood flow to that brain.” 

~ Dr. Nick Delgado

In this Episode

00:00 - Introduction to Dr. Nick Delgado and his work

04:40 - Early work with nutritionist and longevity researcher Nathan Pritikin

09:15 - Dr. Kempner's high-carb, low-fat diet for cognitive protection

13:07 - Insights from a lifestyle medicine pioneer

27:21 - Why the brain does not need high dietary fat

31:05 - The diet that best prevents brain degeneration

38:57 - Case study: reversing Stage 4 Alzheimer’s with multimodal care

51:37 - Synergy vs. single interventions in neurodegeneration

1:07:50 - The impact of stem cells in neuroregeneration

1:14:46 - New technologies Dr. Delgado is excited about

1:18:51 - Key takeaways from today's conversation

Resources:

- Top Supplements for Alzheimer's Guide - https://bit.ly/drjoshguide

- Stop Aging Now: Seven Secrets to Look & Feel Great by Dr. Nick Delgado - https://stopagingnowbook.com/

- Brain Fitness by Dr. Robert Goldman - https://www.amazon.com/dp/0385488645

- The Pritikin Diet & Eating Plan - https://www.pritikin.com/pritikin-program#eating-plan

Connect with Dr. Nick Delgado: 

- Website - https://foreveryoungevent.com/ and https://delgadolabs.com/

- The Delgado Protocol for Health - https://delgadoprotocol.com/

Connect with Dr. Josh Helman, MD:

- Instagram - https://www.instagram.com/greenbrainsMD

- Facebook - https://www.facebook.com/greenbrainsmd/

- LinkedIn - https://www.linkedin.com/in/doctorjosh

- TikTok - https://www.tiktok.com/@greenbrainsmd

- YouTube - https://www.youtube.com/channel/UCUMtFP2icmNEhOaSsd-CrSg?sub_confirmation=1

- Others - https://linktr.ee/greenbrainsmd

Disclaimer: Please remember that this podcast is for informational purposes only and is not intended as medical advice. Always consult your doctor or healthcare professional before making any changes to your treatment plan.