Chris Duffin is joined by Anthony Castor for an in-depth exploration of peptides and their role in optimizing health, training, and recovery.

Together, they break down the complexities of building peptide protocols—discussing how to identify bottlenecks in your own training or wellness, the art and science of combining interventions effectively (without overcomplicating or wasting resources), and why understanding cellular pathways and mechanisms of action matters. 

Whether you’re curious about cellular medicine, looking to fine-tune your supplement stack, or just want sharper tools in your resilience toolbox, this episode offers practical, actionable wisdom to help you get the most out of your health and performance strategies—without unnecessary complexity. Let’s get started!

 

Here are my top three takeaways from the episode:

• Precision Beats Overload: When it comes to peptides (and training), more isn’t always better. Identify your “bottlenecks” and use the least amount of intervention necessary. Streamline your approach and only deploy peptides with mechanisms that authentically support your goals.

• Understand the Mechanisms: Before layering in another supplement or peptide, take the time to map out which cellular pathways you want to target—and avoid overlap or counterproductive combinations. Knowing howsomething works is crucial to making smart choices (the “why” matters, not just the “what”).

• Continuous Assessment is Key: Monitor progress with clear performance indicators—whether that's lab work, improved cognition, or how you feel. Be ready to adjust your protocol, rotate interventions, and remove what you no longer need.

 

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by 

@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin

@bearfootshoes : The Original Barefoot Lifting Shoe 🐻🦶🏼 Use code RESILIENCE for 10% off your order at https://www.bearfoot.store

 

00:00 Optimizing Training with Peptides

03:45 "Optimizing Peptide Pathways"

07:14 Insulin Sensitivity and Oxidative Stress

12:17 Streamlined Supplement Strategy

15:40 Optimal Training: Quality Over Quantity

17:16 Understanding Key Performance Indicators

 

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