Cracking Addiction

By MeducateMedicine Health & Fitness

Cracking Addiction episodes

March 09, 2022 Suboxone Part 2
In episode 30 of Cracking Addiction we discuss the different opioid receptors buprenorphine acts upon and the nature of these effects, the difference between agonists and antagonists, how to start a patient on Suboxone and how to monitor patients on Suboxone and adjust doses.
Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.
Latest Blogs
https://www.meducate.com.au/blog
About Meducate ®
Meducate provides online education for doctors, clinicians, health professionals and the public.
See the website to browse the many different talks and courses available https://www.meducate.com.au
23 min
March 02, 2022 Suboxone Part 1
In episode 29 of Cracking Addiction we discuss Suboxone and talk about the components of Suboxone as well as the pharmacology and pharmacokinetics of Suboxone.
Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.
Latest Blogs
https://www.meducate.com.au/blog
About Meducate ®
Meducate provides online education for doctors, clinicians, health professionals and the public.
See the website to browse the many different talks and courses available https://www.meducate.com.au
19 min
February 23, 2022 LAIB - Top Tips
In episode 28 of Cracking Addiction we discuss our practical tips, advice and experience in managing patients on LAIB and share what we have learned.
Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.
Latest Blogs
https://www.meducate.com.au/blog
About Meducate ®
Meducate provides online education for doctors, clinicians, health professionals and the public.
See the website to browse the many different talks and courses available https://www.meducate.com.au
20 min
February 16, 2022 LAIB The Patient Arc
Episode 27 of Cracking Addiction discusses the patient journey on LAIB and how to adequately deal with and manage adjusting doses of LAIB, commencing and ceasing LAIB and ensuring that patients are maintained on LAIB therapy
Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.
Latest Blogs
https://www.meducate.com.au/blog
About Meducate ®
Meducate provides online education for doctors, clinicians, health professionals and the public.
See the website to browse the many different talks and courses available https://www.meducate.com.au
16 min
February 09, 2022 LAIB - Sublocade
Cracking Addiction discusses Sublocade one of the LAIB preparations available and how to commence, maintain and manage any dose changes or complications associated with Sublocade.
Sublocade is a long acting injectable buprenorphine (LAIB) manufactured by Invidior that uses the “Atrigel” system to provide for a sustained and prolonged delivery of buprenorphine into the systemic circulation after subcutaneous injection.
Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.
Latest Blogs
https://www.meducate.com.au/blog
About Meducate ®
Meducate provides online education for doctors, clinicians, health professionals and the public.
See the website to browse the many different talks and courses available https://www.meducate.com.au
16 min
February 03, 2022 LAIB - Buvidal
Cracking Addiction discusses Buvidal one of the LAIB preparations available and how to commence, maintain and manage any dose changes or complications associated with Buvidal.
Buvidal is a long acting injectable buprenorphine (LAIB) preparation manufactured by Camurus and uses “FluidCrystal” technology to provide for a sustained and prolonged delivery of buprenorphine into the systemic circulation after subcutaneous injection.
18 min
January 26, 2022 LAIB Special Circumstances
Cracking Addiction discusses some of the special or difficult circumstances of prescribing LAIBs including intoxicated patients, pregnant patients, patients with chronic disease, patients with acute pain and our management strategies in these situations.
20 min
January 20, 2022 LAIB first dose considerations
Episode 23 of Cracking Addiction explores commencement of patients on LAIB, side effects and risks of LAIB, discussion about precipitated withdrawal and when and how to review patients
21 min
January 12, 2022 Long Acting Injectable Buprenorphine (LAIB) - Introduction
An Introduction to Long Acting Injectable Buprenorphine (LAIB)
Long acting injectable buprenorphine (LAIB) are long acting buprenorphine depot preparations that are injected subcutaneously and provide patients with a sustained release of buprenorphine for the duration of the depot preparation. Currently, two LAIB products are available for the Australian market. They differ in their formulations, administration and pharmacology.
See blog for further information
https://www.meducate.com.au/blog
About Meducate ®
Meducate provides online education for doctors, clinicians, health professionals and the public.
See the website to browse the many different talks and courses availablehttps://www.meducate.com.au
19 min
December 22, 2021 Methadone pharmacokinetics and interactions
Episode 21 of Cracking Addiction explores methadone pharmacokinetics, breakdown and interactions within the body and interactions with other drugs.
Methadone is a drug with a wide variability in its absorption with oral bio-availability ranges from 35% to 100%. This is a significant amount of variability and explains why the same dose of Methadone can impact different patients differently.
Methadone is metabolised within the liver by the cytochrome P450 enzymes but mainly 3A4. There is a 17-fold inter-individual variation of methadone blood concentration for a given dosage and variations in metabolism account for a large part of this variation. Kinetic interactions influenced by the CYP 450 enzyme can affect plasma methadone levels.
• Inducers of CYP450 can
• Accelerate the metabolism of methadone
• lower methadone plasma levels
• Precipitate opioid withdrawal
• Inhibitors of CYP450 can
• Slow the metabolism of methadone
• Increase plasma levels
• Produce opioid toxicity (sedation, overdose)
Methadone is excreted renally with approximately 10% of drug renally eliminated unchanged. Renal excretion of methadone urinary pH dependent with increased Methadone excretion noted at pH less than 6 and decreased Methadone excretion at higher pH levels.
About Meducate ®
Meducate provides online education for doctors, clinicians, health professionals and the public.
See the website to browse the many different talks and courses availablehttps://www.meducate.com.au
17 min

About Cracking Addiction

From the publisher's feed

Seeking answers about addiction or supporting someone on the path to recovery? Welcome to Cracking Addiction, the podcast that empowers you with knowledge and hope.