DDT Method Podcast — Peptides, Performance Enhancement and Advanced Protocols with Drew Donaldson

Join the DDT Method Skool Group for unfiltered peptide, PED, and training deep dives (50+ exclusive videos, new drops weekly): https://www.skool.com/ddtmethod

In this episode of the DDT Method Podcast, I’m joined by Functional Patterns founder Naudi Aguilar to dismantle mainstream training dogma and rebuild it from the ground up. We cover why most people get diet and biomechanics completely backwards—and how fixing your gait, posture, and fascia can literally “train you out of a bad diet.”

Naudi explains why linear barbell lifts (deadlifts, back squats, power cleans) create massive mal‑adaptations for 99% of normal bodies, how chronic imbalances drive stress hormones and emotional eating, and why your real KPIs are standing, walking, running, and throwing—not your 1RM.

We also dive into:

• Why “you can’t out‑train a bad diet” is incomplete (and how Naudi actually did it)
• How dysfunctional biomechanics trigger stress, binge‑eating, and hormonal chaos
• Why gait and fascia‑centric training are the future of strength & conditioning
• What Functional Patterns actually is (beyond IG clips and hate‑reacts)
• The real difference between Naudi and Paul Chek, and why KPIs matter more than exercises
• Why most “evidence‑based” programming is still naive about complexity and real‑world results
• How FP helps MMA champions and wrestlers get more skill reps with less pain and fewer injuries

If you’re a coach, biohacker, enhanced athlete, or just a jacked nerd who knows something is off with “normal” training, this episode will give you a completely different lens on biomechanics, fascia, and performance.

Connect with Functional Patterns:

Functional Patterns Website & Courses: https://functionalpatterns.com

FP Evidence Page (Before/After Transformations): https://instagram.com/fp.evidence

Naudi’s Personal Page: https://www.instagram.com/theleverking/

High-level biohacking intel: https://www.skool.com/ddtmethod

Dom Cardone is an IFBB Pro who won his pro card at 21, started coaching at 16, and has been mentored by some of the most respected names in bodybuilding, including Dante Trudell, Chad Nichols, Oscar Arden, Chris Aceto, and Fakhri Mubarak.

In this episode, Drew Donaldson and Dom Cardone break down what enhanced athletes are getting wrong about testosterone, growth hormone, retatrutide, blood pressure, peptide foundations, and online coaching. Dom explains why the old-school 500mg first-cycle default may be too aggressive, how low he has seen retatrutide work in real clients, why blood pressure needs to be treated like a serious performance marker, and why more information is not always making athletes better.

Join the DDT Method School community for $10/month — over 50 exclusive videos and articles, with new ones every week: https://www.skool.com/ddtmethod

Brandon Eisenlauer returns to DDT Method after spending 3-4 years on both the front-end and back-end of the peptide industry. He's now the founder of Adera State, a brand built to drag peptides out of the research-chem vial era and into the mainstream — through transdermals, nasal sprays, pouches, and blends engineered with a pharmaceutical-chemistry R&D team.

In this episode, Brandon and Drew lay out exactly how the peptide and supplement industries are about to be rewritten — what stays, what dies, and the 18-month window before everything changes. They get into why "feeling it" is the worst way to judge a peptide, why pharma is often ahead of the biohacking space (not behind it), and what the next generation of mainstream-friendly peptide products actually looks like.

Key Takeaways:

• The peptides everyone's stacking that Brandon says is already behind the curve
• Why "feel" is one of the worst ways to judge whether a peptide is working
• The 18-month window before the supplement industry looks nothing like it does today
• The molecular size cutoff that determines whether a peptide can go transdermal — and what to do above it
• Why a 60-70% effective topical can beat a 100% effective injectable for most users
• What RFK actually means for peptide access — and why it's not what the research community thinks
• The unspoken reason injectable GLPs and topicals are heading in opposite regulatory directions
• The new Adera State product Brandon is most excited about (and the unusual delivery vehicle behind it)
• The "social performance" stack he gives to people who need to be on for work
• Where the research-chem industry actually ends up by 2027

Connect with Brandon:

Adera State: https://aderastate.com

Biohacking U (free education library): formerly paid, now 100% free

Connect with Drew Donaldson:

DDT Method School: https://www.skool.com/ddtmethod

Coaching: https://ddtmethod.com/application

Want to go deeper on peptides, PEDs, and protocols? Join the DDT Method School Group for $10/month: [SKOOL LINK]

Jeremy Warner has been in the fitness industry since 2000. He's a certified Muscle Activation Techniques specialist, a student of Patrick McKeown's Oxygen Advantage, and recently completed Martin McPhilimy's School of Breath Science. He now runs Performance Breath Training, working one-on-one and in group classes with athletes, bodybuilders, and general population clients who want to use their breath as an actual performance lever.

In this episode, Drew and Jeremy dismantle the biggest misconception in fitness: that breathwork is a "woo-woo" calming practice. Jeremy breaks down the physiology behind why hyperventilation before training — the Wim Hof hack everyone copies — actually reduces oxygen delivery to working muscle, why most people burn carbs instead of fat during zone 2 cardio, and how a simple 2-minute pre-workout breath protocol can replace your pre-workout stim stack. If you've only known breathwork as something you do to fall asleep, this episode will rewire how you think about every single workout.

CHAPTER MARKERS

00:00 The Ranking That Shocks Everyone

02:53 Who Is Jeremy Warner

06:14 Why Breathwork Isn't Woo-Woo (The Lactate Shuttle)

16:50 Breathing Mechanics & The 2-Minute Pre-Workout Protocol

31:26 CO2 Tolerance, Zone 2, and the 5-Gear System

41:32 The Wim Hof Problem and The Bohr Effect

49:00 Building a Training Session: VO2 Max & The Nordic 4x4

56:11 Sauna + Breath: The Oxygen Dissociation Trick

59:46 Cold Plunge: When It Helps and When It Wrecks You

66:04 Where to Find Jeremy Warner

KEY TAKEAWAYS

• The pre-workout breath ritual that one coach ranks above every stim stack on the market
• Why your Wim Hof session before training might be the reason you're gassing out early
• The reason most people burn carbs instead of fat during "fat-burning" cardio — even when their heart rate is perfect
• The energy system nobody talks about that decides how well you recover between sets
• What a 25-year fitness veteran does in the 2 minutes before every single workout
• The hidden reason your mouth breathing is stealing gains you earned at the gym
• The one recovery metric that predicts whether you can train hard again tomorrow

CONNECT WITH JEREMY WARNER

• Website: https://performancebreathtraining.com
• Instagram: @performancebreathtraining

Join the DDT Method Skool Group for exclusive deep-dive videos on peptides, PEDs, and protocols: https://www.skool.com/ddt-method

Tom Schuster (@CoachTomFit) is an emerging performance coach who went from 105 lbs in a wheelchair after a near-fatal blood clot at age 16 to 255 lbs — gaining over 150 lbs and defying every medical prediction along the way. He now coaches enhanced athletes across the full spectrum from biohacking to bodybuilding competition prep.

In this episode, Drew and Tom break down exactly how to structure compounds, peptides, and protocols for the enhanced athlete who wants maximum results without destroying their health. They cover Increlex, Equipoise vs. DHTs, the 3-peptide rule, female enhancement protocols, SLU dosing truth, DNP in prep, and why understanding how drugs work — not just what they do — is the only thing separating elite coaches from the noise.

Key Takeaways:

• Why one compound is quietly becoming the most talked-about thing in enhanced circles for 2026
• The hard rule on peptide stacking that most coaches are violating — and what it's costing their clients
• Tom's go-to anabolic for growth phases and why he picks it over the popular choice 9 out of 10 times
• How Tom navigates female enhancement without virilization — starting at a dose that will shock most coaches
• Drew's evolving SLU experiment from micrograms to milligrams and what he's actually seeing
• The one piece of biochemistry knowledge that Drew says should be a minimum standard for anyone recommending peptides
• Why the "more is better" peptide culture mirrors the supplement hoarding era of the 2000s
• Tom's 4-pillar picks if he could only use 4 compounds forever
• The real difference between coaches who understand mechanisms vs. coaches who memorize drug profiles

Connect with Tom Schuster:

YouTube: https://www.youtube.com/@CoachTomFit

Instagram: https://www.instagram.com/tomschusterfit/

Connect with Drew Donaldson:

YouTube: https://www.youtube.com/@TheDDTMethod

Instagram: https://www.instagram.com/drew_donaldson

Deep dive into protocols → Join the DDT Method community: https://www.skool.com/ddtmethod

Hunter Williams and Taylor Williams — two of the most respected coaches in the peptide and performance enhancement space — return to the DDT Method Podcast for a comprehensive deep dive into building intelligent protocols from the ground up. This husband-and-wife coaching duo works with hundreds of men and women, and they bring real-world, anecdotal evidence to every recommendation.

This episode covers Hunter's 5-Bucket Protocol Framework (reproductive hormones, growth hormone, thyroid, insulin sensitizers, and mitochondrial support), Taylor's women-specific layering approach, the emerging molecules catching their attention (P21, PE2228, MK-777, injectable bioregulators, transdermal peptides), a full GLP selection guide (tirzepatide vs. retatrutide sequencing), mitochondrial optimization (SS31, MOTC, SLU dosing, ATX as an alternative), the case for SGLT2 inhibitors over metformin, and underrated muscle builders like IGF-1 LR3.

CHAPTERS:

00:00 The State of the Industry & Peptide Fatigue

03:47 Taylor's Nootropic Deep Dive: P21 & PE2228

07:22 Injectable Bioregulators & Cartilax Results

09:54 The Transdermal Peptide Wave

12:26 The Problem With Stacking Without a Plan

16:37 Hunter's 5-Bucket Protocol Framework

19:12 Taylor's Women-Specific Layering Approach

22:00 Building the Male Protocol: Bucket by Bucket

25:42 MK-777: The Oral GH Secret Nobody Expected

30:30 Mid-Roll: DDT Method Skool Community

31:27 GLP Selection: Why Tirzepatide Before Retatrutide

35:37 Drew's Approach: Pulling One Lever at a Time

38:14 Mitochondrial Optimization: SS31 vs. MOTC Sequencing

42:20 Taylor's SLU Burnout Story & Recovery

47:54 Hunter's SLU Dosing Journey: From 100mcg to 2mg and Back

51:09 ATX: The AMPK Activator With Human Trial Data

52:59 Metformin, Jardiance & SGLT2 Inhibitors

58:16 Drew's HDL Results on 50mg Anavar + Jardiance

59:24 Underrated Compounds: ACE-167 & IGF-1 LR3

1:04:54 Where to Find Hunter & Taylor Williams

KEY TAKEAWAYS:

• Hunter's 5-Bucket Framework for building a complete peptide protocol from scratch
• Taylor's women-specific layering approach and why it differs from what most coaches recommend
• The oral GH alternative that rivaled Hunter's injectable protocol — with Oura data to back it up
• Why starting with the "best" GLP might actually be the worst move for new users
• The mitochondrial sequencing mistake that's leaving people exhausted instead of energized
• Taylor's firsthand experience pushing SLU too high — and what it did to her nervous system
• The AMPK activator with human trial data that delivers SLU-like fat loss without the burnout
• The drug combination that may make metformin obsolete — and the blood work to prove it
• The most underrated muscle builder that even experienced athletes keep overlooking
• A pipeline molecule nobody's talking about yet that could change natural testosterone

CONNECT WITH HUNTER & TAYLOR WILLIAMS:

Hunter's Website: https://hunterwilliamshealth.com

Hunter's YouTube: Hunter Williams Podcast

Taylor's YouTube: Taylor Williams Peptides

Instagram: @hunterwilliamscoaching / @taylorwilliamscoaching

Join the DDT Method community for exclusive deep dives on PEDs, peptides and biohacking protocols: https://www.skool.com/ddt-method

Josh Settlage is a strength and conditioning coach specializing in grappling and combat sports athletes. A protege of Mark Bell, Josh spent years learning at Super Training Gym before building The Strength Matrix -- his coaching practice dedicated to helping grapplers lift heavy and roll hard.

In this episode, Drew and Josh break down why being "jacked in all areas of conditioning" matters the most to being a well rounded athlete. They cover the three energy systems you MUST train, why the "no cardio" flex is actually holding back your gains, how to apply conjugate training methods for any goal (not just powerlifting), the truth about HIIT misconceptions, and performance-enhancing compounds like DADA, BAM-15, L-carnitine, ITPP, and injectable glutathione for conditioning and recovery.

Key Takeaways:

• Being conditioned across all energy systems (ATP-phosphocreatine, fast glycolysis, aerobic) is the mark of a complete athlete
• Building your aerobic base helps you recover faster between strength sessions and add more training volume
• True HIIT uses a 1:3 work-to-rest ratio at 15-30 seconds of real intensity -- not 40 minutes of moderate effort
• The VIP Method (Vision, Intention, Purpose) is the framework for breaking through training plateaus
• DADA increases ATP yield from glucose (more performance); BAM-15 decreases ATP efficiency (more fat burning) -- never combine on the same day
• Condensed conjugate (max effort + dynamic effort + repetition effort) in a 3-day split builds muscle without sacrificing explosiveness or conditioning
• Injectable L-carnitine is glycogen-sparing and helps sustain energy in long training sessions
• Injectable glutathione used every 2-3 weeks acts as a "fire extinguisher" for accumulated oxidative stress
• When people say they follow their diet 80/20, it's really more like 50/50 -- push to 90/10 for 12 weeks and see what happens

Connect with Josh Settlage:

YouTube: @JoshSettlage

Instagram: @JoshSettlage

Coaching: https://thestrengthmatrix.com

Connect with Drew Donaldson:

YouTube: @DDTMethod

Instagram: @DDTMethod

Join the DDT Method community → https://www.skool.com/ddtmethod

Mike White (@mike.ryan.white) is a PhD Candidate in Clinical Physiology, former D1 Strength & Conditioning Coach, and coach to enhanced athletes who believe health management should be as rigorous as training programming. In this episode, Mike breaks down the real ceiling on SLU-PP-332 dosing (he ran 500mg/day to find it), why telmisartan is more than a blood pressure drug, the GLP-1 debate that's splitting the coaching world, and why "chicken and rice coaching" is failing athletes when it matters most.

Drew and Mike go deep on peptide periodization, mitochondrial health strategy, retatrutide's underrated fat loss mechanisms, the overlooked power of LL-37 for gut health, and how to use DNP responsibly on rest days. This is protocol-level conversation for athletes who are done guessing.

Chapters:

0:00 - The Craziest Cycles Ever Run

3:35 - Who Is Mike White?

9:06 - What Is a "Chicken and Rice Coach"?

14:06 - Common Health Issues in Men & Women

21:15 - Drew's Personal Health Stack

22:54 - Optimizing Health on TRT Plus

24:46 - Cardio Programming for Every Client

26:22 - Training Philosophy: Low Volume vs. High Volume

31:15 - SLU-PP-332: From 250mcg to 500mg

36:13 - Understanding SS-31 & Mitochondrial Peptides

39:07 - Biggest Peptide Mistakes People Make

41:53 - GLP-1s Are Not Cheating

49:53 - Underrated PEDs, Peptides & Supplements

54:40 - Sodium, Potassium & Electrolyte Balance

1:00:11 - Hidden Gems: LL-37 & DNP

1:05:41 - Where to Find Mike White

Key Takeaways:

• SLU-PP-332 has an effective ceiling at ~100mg — at 500mg, Mike experienced DNP-like heat and metabolic dysfunction with no additional benefit
• Telmisartan up to 320mg/day offers benefits beyond blood pressure: PPAR gamma activation, brain health, cardiac remodeling, and renal protection
• GLP-1s are not cheating — 1 in 8 adults is currently on one, with benefits including lipid oxidation, neural inflammation reduction, and insulin sensitization
• Retatrutide is one of the few fat loss tools that enhances both lipolysis and beta oxidation simultaneously
• LL-37 for GI health is massively underutilized — gut dysfunction creates a bottleneck for muscle gain, fat loss, and cognitive function
• DNP at low, intermittent doses (rest days only) is a legitimate tool when given the respect it requires
• "More is not better. Better is better." — applies to peptides, training, and every protocol decision

Connect with Mike White:

Instagram: @mike.ryan.white

Coaching Education Cohort: May 1st — DM Mike on Instagram

Gray Matter MD Clinic: Launching Q2 2026 — TRT & hormone optimization in all 50 states

Connect with Drew Donaldson:

DDT Method Skool Group: https://www.skool.com/ddtmethod

Instagram: @ddtmethod

#peptides #SLU332 #GLP1 #telmisartan #retatrutide #DNP #bodybuilding #enhancedathlete #PEDs #mitochondrialhealth #DDTMethod #MikeWhite #bloodpressure #fatloss #musclegain #LL37 #biohacking

For the science nerds → Advanced biohacking research: https://www.skool.com/ddtmethod

In this episode of the DDT Method Podcast, Drew Donaldson sits down with coach Paul Romczak to break down the GMT Method—a gut–mitochondria–training framework that fixes the broken foundations behind most peptide and PED abuse. They reveal why stomach acid, butyrate production, metabolic health, and carb cycling matter more for long‑term hypertrophy than stacking the latest GLP‑1 or mitochondrial peptide. If you’re a 29–45‑year‑old lifter on TRT who wants to be cartoon‑character jacked and live a long time, this is your roadmap.

CHAPTERS:0:00 Why Peptides Aren’t Fixing Your Broken Foundations3:12 The GMT Method Explained: Gut → Mito → Training8:45 The “Skinny Biohacker vs. Bloated Bodybuilder” Problem14:20 Fixing Stomach Acid: The Fastest Gut Health Win19:40 Butyrate, Fiber, and What Leaky Gut Really Is26:05 Metabolic Health 101: Lose the Body Fat First32:30 Carb Cycling for Insulin Sensitivity and Performance38:50 SS‑31, SLU, and 5‑Amino‑1MQ: When Peptides Actually Make Sense46:10 Smart Use of GLP‑1s, Mito Peptides, and Breaks for Resensitization53:40 DNP, Uncouplers, and Why Paul Pushes Hard Early in Prep1:01:15 Clen, Yohimbine, and Old‑School Tools That Still Work

High-level biohacking intel: https://www.skool.com/ddtmethodJon Andersen went from being a bullied, overweight kid in special education to becoming an international pro strongman, New Japan Pro-Wrestling star, and IFBB pro bodybuilder -- all without ever holding a traditional job. In this episode of the DDT Method Podcast, Jon breaks down the "Deep Water" mentality that fueled his success across three sports, three seven-figure businesses, and his current approach to peptides, diet, and longevity at 54 years old.KEY TAKEAWAYS:- Why Jon Andersen credits being a "slow learner" as the single greatest gift that built his entire career across three professional sports- The unconventional protein-only diet approach Jon stumbled into 15 years before science validated it -- and why he still uses it today- How the "Deep Water" mentality of accepting failure before you start a set unlocks reps you never knew you had- The specific peptide stack Jon used to completely reverse nerve damage in his dominant arm and eliminate decades of scar tissue- Why Jon believes retatrutide is the one peptide he would choose above all others, and the unexpected mental health benefits he experienced- The two non-negotiable lifestyle habits Jon says matter more than any peptide or supplement protocolCHAPTERS:0:00 Introduction and Jon Andersen's Origin Story2:22 How Being a "Slow Learner" Became His Superpower5:40 The Accidental Protein Diet That Changed Everything9:02 From First Strongman Contest to International Pro13:02 Flipping Real Estate to Fund the Dream16:14 The Deep Water Mentality Explained19:15 Breaking Into Pro Wrestling with a Fake Resume27:44 Earning an IFBB Pro Card at 42 in Two Shows34:01 The 2008 Crash and Rebuilding Everything38:03 Training and Recovery Evolution at 5443:25 Detox Protocols: Glutathione to TUDCA48:34 Peptide Journey: Early Use to Current Stacks54:35 Retatrutide: The One Peptide He'd Pick Above All59:16 ARA-290, TB-500, and Reversing Decades of Damage1:04:17 Where to Find Jon Andersen OnlineEPISODE RESOURCES:Jon Andersen's Social Media:Instagram: https://www.instagram.com/thejonandersenWebsite: https://japrotocols.comCellular Advantage Academy: https://cellularadvantageacademy.comDeep Water Program: https://www.jon-andersen.com/free-deep-water-ebook/