The Funk'tional Nutrition Podcast

Detox or Re-Tox? Why Beta Glucuronidase Can Block Hormone & Toxin Clearance | Ep 381


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If you’ve ever seen beta glucuronidase pop up on your stool test and wondered what it actually means, this episode breaks it all down. This powerful enzyme made by bacteria in your gut can UNDO your body’s detox work by “unboxing” toxins and hormones that were meant to be eliminated, leading to bloating, breast tenderness, and stubborn weight gain, even when your estrogen levels look normal.

Erin walks through the 3-phase detox process and how gut imbalances, constipation, or low-fiber diets can allow estrogen and other toxins to recirculate in your system.

You’ll learn both short-term strategies like calcium D-glucarate and long-term fixes to bring your beta glucuronidase back into balance. 

In this episode:
  • How low fiber intake, sluggish motility, and alkaline pH drive beta glucuronidase levels higher and disrupt detox
  • How constipation and slow transit time can stall your detox efforts, allowing toxins and hormones to be reabsorbed 
  • Erin’s strategies for addressing high beta glucuronidase, from calcium D-glucarate to long-term microbiome restoration
  • Why you can experience estrogen dominance symptoms like breast tenderness, bloating, and mood swings, even when your estrogen levels are low
  • The “gift-wrapped present” analogy that reveals how your body safely packages up hormones and toxins, and how beta glucuronidase rips the bow off


Resources mentioned:

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FOR OUR FULL LIST OF LINKS + RESOURCES, HEAD TO: 

https://www.thefunktionalnutritionist.com/podcast/381-beta-glucuronidase 

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The Funk'tional Nutrition PodcastBy Erin Holt

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