Heart attack and stroke have many causes and risk factors, ranging from lifestyle, obesity, diabetes, hypertension, high cholesterol, inflammation, dental infections, stress, etc. Which of these is the real cause? Maybe it's a common factor, like the mitochondria and cellular respiration. The reality is that we do not know. Cellular respiration and the mitochondria theory can be helpful in terms of both research questions and lifestyle, treatment issues. The functional item is what comes of the knowledge. What can we do to prevent or reverse early disease? For example, we know that there are many things we can do to decrease disease: a proper diet, exercise, and specific medications when indicated. There are a couple of examples: ACE inhibitors and insulin resistance. We know that ACE inhibitors and ARBs improve insulin resistance. ACE inhibitors improve inflammation as well, so we recommend those when the patient tolerates them. Beta-blockers have been shown to improve life expectancy post cardiovascular events. But one thing we often don't think about is the fact that so much cardiovascular risk is driven by insulin resistance ( est 70%). If that's the case, should we consider beta-blockers that have a positive impact on diabetes? I think so. But this is often ignored in the hurried medical practice. If you're on Toprol or metoprolol and have cardiovascular risk and diabetes, consider carvedilol or Coreg.

Vit D was thought to be a non-issue when it was provided as a preventive of Rickets. Rickets was a disabling disease of bone deformity of children. Over the past decade, we've discovered that Rickets was just the tip of the iceberg. Now we're discovering multiple functions, especially anti-inflammatory in nature. Significant evidence supports the prevention of cardiovascular disease, multiple cancers, and even mental health issues. The Wikipedia site on Vit D appears outdated. It doesn't mention the recent data about these issues. Vit D toxicity is a debatable condition. Toxicity has been reported to kidneys at doses over 50 times the recommended amount. Vit D increases calcium absorption by the gut. But what happens next? That's supposed to be where Vit K2 enters the picture. Vit K2 is involved in getting calcium to the bone. There is evidence that k2 decreases the deposition of calcium in the artery walls. The scientific evidence in this area is growing.

This is an unboxing video. It's Day 2 of my experience with Prolon. Prolon is a fasting-mimicking (meal replacement) product developed by one of the world's leading researchers in the genetics and biochemistry of longevity. He has demonstrated improvement in multiple markers, including cholesterol, inflammatory markers, stem cell performance, and the metabolic pathways IGF-1, mTOR, and PKA. These pathways are all related to aging. The actual contents, foods, soups, supplements, and teas are demonstrated. There is also a brief biochemistry explanation re: the tea sweetener - glycerine. Glycerine is a carbohydrate, but it is low glycemic. Perhaps more important, glycerine is the backbone of triGLYCERIDES - or fat molecules. So in a fasting state, you should be making ketones and creating/burning glycerine. In other words, the sweetener used is already being made by the body in the fasting state.

To get Valter Longo's Prolon ( Fasting Mimicking Diet, go to: https://prevmedheartrisk.gethealthy.s...

You can obtain Valter Longo's Fasting Mimicking Diet (Prolon) at: https://prevmedheartrisk.gethealthy.s... There is a lot of buzz re: curing diabetes. Valter Longo at USC Davis is one of the world's top biochemists/geneticists focused on gerontology or longevity. He's demonstrated stem cell-mediated regrowth of beta cells in the pancreas in mice. The mice were cured of their diabetes. Can we do that with men as well? Other articles by Longo are reviewed demonstrating improvement of multiple metabolic indicators, mostly driven by the glucose metabolism pathways including mTOR, AMPK, ILG-1. A final academic article demonstrates the probable mechanism. Caloric restriction or fasting clearly increases the transcription of genes that code for these proteins. P53 and FOXO appear to be acting agents in this transcription improvement - or upregulation. In the end, this all makes sense. Episodes of caloric restriction cause our bodies to transcribe more of the genes involved in energy metabolism. It makes sense after.

There is NO DEBATE about the fact that getting less than 7.5 hours of sleep causes obesity, diabetes, high blood pressure, dementia, and early death. We'll do a brief mention of science reviews of the literature. Here are some links to studies: https://www.hindawi.com/journals/ije/... http://journals.plos.org/plosmedicine... http://journals.plos.org/plosmedicine... Science has been there for a long time. Unlike the debate on low fat and plant-based vs low carb, there is absolutely no debate about the science in this area. Sleeping less than 7.5 hours causes diabetes, insulin resistance, obesity, hypertension, and death. About Dr. Brewer - is a physician that started as an Emergency Doctor. After seeing too many patients coming in dead from early heart attacks, he went to Johns Hopkins to learn Preventive Medicine. He went on the run the post-graduate training program (residency) in Preventive Medicine at Hopkins. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has over 500 primary care/ prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack, stroke, and diabetes prevention clinic. At PrevMed, we focus on heart attack and stroke and Type 2 diabetes prevention by reducing or eliminating risk through attentive care and state-of-the-art genetic testing, imaging, labs, and telemedicine options. We serve patients who have already experienced an event as well as those who have not developed a diagnosis or event. Our team of senior clinicians includes internationally recognized leaders in the research and treatment of cardiovascular disease, preventive medicine, and wellness. We also provide preventive medicine by telemedicine technology to over 30 states.

Homocysteine, folate, methylation, and monoamine metabolism in depression. Teodoro Bottiglieri et al. British Medical Jl This is an old study. It's been cited over 500 times. Here's why. they took severely ( hospitalized) depression patients and controls: and 1. it looked at methylation indicators in serum, red blood cells, and even cerebrospinal fluid; 2. documented an inverse relationship between serum homocysteine and all other indicators for products of methylation, INCLUDING metabolite indicators of monoamine neurotransmitter metabolism. In other words, there was strong evidence that the methylation metabolism failure was linked to depression.

Diet 101 is a companion book to Blood Sugar 101, but Jenny Ruhl. She's the founder of the award-winning website Blood Sugar 101. Like Blood Sugar 101, this is a very well-researched book. And it also was written for diabetics. However, the information provided is important for all of us. And it's not just for diets and weight loss. It's also for the Type 2 diabetes pandemic. She does an excellent review of the new studies coming out over the past few years re: studies of diets using stronger scientific techniques. Actually, diets routinely don't do well. Here's why; people don't stick with them. 6-month follow-up for almost all diet studies has been abysmal. Low carb diets have shown marginal improvement. Do ketogenic diets have a metabolic advantage? Yes, but you can't eat 7000 calories per day. Jenny's a proponent of low-carb diets, especially for diabetics and prediabetics. But she fairly reports problems and shortcomings, like grumpy moods, quick loss of improvement when carbs are re-introduced, failure to prevent or cure diabetes or prediabetes.

This is part 2 with a summary of the scientific literature on CoQ10 and Ubiquinol.

It's clear that CoQ10 is safe, important, expensive, that it's a key component of animal cell respiration and drives over 90% of our energy production, it's depleted during disease states such as heart failure, stroke, and cardiovascular inflammation. It is also depleted by statins.

But what's not clear is whether improving levels of CoQ10 actually improve athletic performance and disease outcomes.