The Nutrition Science Podcast

Episode #34: Genetics Matter: How the APOE Gene Can Influence Your Response to High Fat Dieting


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In this episode we are going to continue the theme about high fat and ketogenic diets and talk about how genetics can influence our response to fat consumption. We have known about bio-individuality going back 1000s of years to Ayruvedic medicine, however, the mapping of the human genome and ongoing research is now giving us some very detailed information about how an individual might respond to a specific treatment.

Today, we are going to talk about the APOE gene which regulates the ApoE protein which is involved in the transport, uptake, and excretion of fat and cholesterol in our blood, but more importantly in our brain. Carriers of specific types of this gene are going to be at significantly increased risk of heart disease and Alzheimer’s disease if they follow a higher fat dietary pattern compared to the majority of the population. The information in this podcast is part of a new field of nutrition called nutritional genomics, where we will be able to determine the best diet for YOU, based on your genes. 

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The Nutrition Science PodcastBy Dr. Adrian Chavez

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