Solving the Puzzle with Dr. Datis Kharrazian

Episode 41: Understanding Hormone Disorders


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In this episode we dive into the intricate web of hormone imbalances, menstrual disorders, and andropause. We explore the impact of estrogen and progesterone imbalances on the menstrual cycle, as well as the role of prostaglandin imbalances in conditions like dysmenorrhea and PMS. We also uncover the complexities of andropause in males and address the various symptoms and treatment options available.


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00:00 Female and male hormone transition patterns summarized.

08:51 BMI impacts endocrine system, genetic factors matter.

12:40 Excessive estrogen production causes gynecomastia in men.

18:51 Prostaglandins influence menstrual pain and discomfort.

26:21 Causes of heavy or light menstrual bleeding.

32:24 High DHE and testosterone levels suggest PCOS.

33:24 PCOS symptoms can normalize with metabolic control.

38:45 PCOS pathophysiology, treatment, and clinical manifestations.

45:19 Adrenal glands help manage perimenopausal symptoms.

49:33 Hormonal changes in perimenopause cause inflammatory response.

59:03 Inflammation and hormones affect women's health.

01:03:18 Menopause can worsen underlying health conditions.

01:06:44 Adulthood: decline in male function and symptoms.

01:13:49 LH levels range indicates potential hormone balance.

01:16:27 Free testosterone is crucial, especially as we age.

01:25:04 Normal range testosterone, relative hypogonad men, DHT.

01:27:26 Male and female hormone disorders patterns explained.



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Solving the Puzzle with Dr. Datis KharrazianBy Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN

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