FoundMyFitness

Michael Snyder

Dr. Michael Snyder is the director for the Center for Genomics and Personalized Medicine at Stanford and a pioneer and advocate of "deep profiling." Deep profiling seeks to apply intelligent analysis to large data sets to yield specialized clinical insight, ranging from common consumer-grade wearables like Apple Watches to whole-body MRI, continuous glucose monitoring, and metabolomics.

In this episode, we discuss:

• (00:00) Introduction to Dr. Michael Snyder
• (12:51) Continuous glucose monitor use in people without diabetes
• (31:04) A smartwatch helped diagnose Dr. Snyder's Lyme disease
• (34:00) Predicting other illnesses with smartwatches
• (40:41) Detecting airborne pollutants in the exosome
• (51:04) Genetics and metabolism tell us our Ageotypes
• (58:05) Exercise is most important for longevity
• (01:03:11) Dr. Snyder's lifestyle habits

If you're interested in learning more, you can read the full show notes.

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Dr. Roger Seheult Dr. Roger Seheult is the co-creator of MedCram Videos. In the early days of the COVID-19 pandemic, MedCram emerged as a beacon of insight, providing continuing coverage and perspectives in an environment almost defined by information scarcity. What particularly excited me about the unique opportunity of this interview is that apart from Dr. Seheult being a unique voice of public scholarship during the early days of the pandemic, he's also a quadruple board-certified pulmonologist with deep experience working on the frontline of the COVID-19 pandemic.

In this episode, we discuss:

• (00:00) Introduction
• (06:20) How MedCram Videos got started
• (09:37) Using evidence to make COVID-19 treatment decisions
• (12:46) The differences in treating early vs late-stage COVID-19
• (14:40) How doctors would've treated COVID-19 one-hundred years ago
• (18:13) Increasing ventilation reduces SARS-CoV-2 transmission
• (20:28) Masks are virtually universally beneficial regardless of type
• (21:32) Vitamin D and COVID-19
• (22:22) Steroid chemical structure of vitamin D
• (23:24) The vitamin D RDA is likely too low
• (24:23) Vitamin D is more like a hormone than vitamin
• (26:21) The overlap between COVID-19 and vitamin D deficiency
• (30:27) How Mendelian randomization studies helped solve the vitamin D puzzle
• (34:20) The gene regulatory effects of vitamin D
• (35:49) Vitamin D and the ACE2/renin-angiontensin system
• (42:00) Daily doses of vitamin D are more effective
• (43:23) A prescription-only form of vitamin D (calcifediol) may be best for COVID-19
• (47:06) Skin synthesis of vitamin D from sunlight can be unreliable
• (53:43) The safest dose range for vitamin D
• (01:06:15) The beneficial circadian effect of early morning sunlight
• (01:07:38) Sleep deprivation impairs vital immunity
• (01:12:08) Dr. Seheult's suggestions for the best sleep
• (01:19:18) A Spanish flu era treatment boosts interferon by ten times
• (01:22:38) Why interferon is so important for the viral response
• (01:26:43) Treating the symptoms of fever during the Spanish flu harmed patients
• (01:31:58) Dr. Seheult's ongoing research of hot hydrotherapy
• (01:47:00) COVID-19 Vaccines

If you're interested in learning more, you can read the full show notes.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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Steve Horvath

Steve Horvath, PhD, is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health

Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan.

In this episode, we discuss:

• (00:00) Introduction and overview
• (20:24) Horvath Aging Clocks
• (26:36) Heredity determines aging
• (35:49) DNAm PhenoAge vs GrimAge
• (45:58) Slowing the epigenetic clock
• (01:10:43) Epigenetics: Cause or consequence of aging?
• (01:16:43) Vitamin D reverses epigenetic age
• (01:19:07) Omega-3 slows GrimAge clock
• (01:24:19) Ongoing research

If you're interested in learning more, you can read the full show notes here.

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Consistent patterns of age-based alterations in DNA methylation can be harnessed to estimate age, serving as a sort of "clock," the premise of which is truly remarkable: Predict a person's age (or even lifespan), based on chemical modifications to their DNA that reflect the biological life history of the organism. Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan.

In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging.

Get this show's notes, timeline, and transcript: https://www.foundmyfitness.com/episodes/steve-horvath

Dr. Horvath's faculty bio page: https://ph.ucla.edu/faculty/horvath

Dr. Horvath's Wikipedia page: https://en.wikipedia.org/wiki/Steve_Horvath

Dr. Rhonda Patrick's 3-minute video crash course in epigenetics: https://www.foundmyfitness.com/episodes/epigenetic-clock

The FoundMyFitness overview article of epigenetic clocks: https://www.foundmyfitness.com/topics/epigenetic-clocks

Dr. Jed Fahey

In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants.

In this episode, we discuss:

• (00:00) Introduction
• (07:19) The minimum daily dose of sulforaphane
• (12:04) Gauging sulforaphane content of foods is challenging
• (17:37) Workarounds to enhance the sulforaphane in cooked foods
• (23:38) How often to consume broccoli sprouts and how long their effects last
• (39:28) The effects of sulforaphane on glutathione production in the brain
• (43:12) The effects of sulforaphane on cancer
• (01:17:26) Alternatives to sprouts, such as supplements (and which ones Dr. Fahey recommends)
• (01:33:08) Safety concerns regarding sulforaphane

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Giselle Petzinger

Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson's disease.

Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure.

In this episode, we discuss:

• (00:00) Introduction
• (06:57) What is Parkinson's disease?
• (11:57) When symptoms of Parkinson's disease appear
• (14:57) Circuits in the brain can compensate for substantia nigra dysfunction
• (18:37) Hereditary risk factors of Parkinson's disease
• (21:25) Parkinson's disease is associated with pesticide and pollutant exposure
• (26:57) Exercise can lower the risk of developing Parkinson's disease
• (35:38) How skill-based exercise such as boxing reduces disease symptoms
• (47:49) Treadmill exercise increased BDNF and brain health
• (58:33) Exercise at 80 percent of maximum heart rate slowed Parkinson's disease progression
• (01:01:31) Why exercise may not fully replace medications
• (01:09:58) DHA reduces motor symptoms and dyskinesia
• (01:12:12) Patients with Parkinson's disease have higher levels of inflammatory biomarkers

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information on Parkinson's disease straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Fasting.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members' podcast feed.

In this previous, you'll learn:

• (00:00) Introduction
• (01:48) Fasting supports a healthy gut microbiome and reduces autoimmunity
• (08:28) Increasing autophagy with fasting
• (13:26) Reducing protein acetylation with fasting mimetics
• (18:17) Fasted exercise, water fasting, and a fasting-mimicking diet

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Sauna use. What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

In this episode, you'll learn:

• (00:00) Introduction
• (01:41) Evidence supporting sauna use for health
• (04:09) How Finnish humid saunas can reduce viral illness
• (08:40) Sauna and hot bath use during the COVID-19 pandemic
• (15:07) Rhonda's sauna routine

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on pregnancy and child development.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

This particular collection of segments covers every single major discussion of pregnancy and child development spanning years of members-only Q&As. In this episode, you'll hear:

• (00:00) Introducing "The Aliquot"
• (02:43) Omega-3s for babies and toddlers to maximize brain development
• (07:02) Common nutrient deficiencies in children and how to prevent them
• (11:42) Evidence to support omega-3 supplementation in children
• (20:58) Fasting considerations and restrictions for women

Learn more about our premium podcast feed The Aliquot by clicking here.

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

This episode aims to be the most comprehensive video compendium on the biology of breast milk ever recorded.

In this episode, you'll discover:

• (00:00) Introduction
• (07:11) Breast milk production and composition
• (09:59) Human milk oligosaccharides help establish the infant gut microbiome
• (16:32) Omega-3s in breast milk boost brain development
• (18:15) Vitamins and minerals in breast milk
• (22:05) Breast milk stem cells and multi-organ microchimerism
• (22:54) Harmful substances transferred to infants via breast milk
• (28:05) Breastfeeding boosts the infant's immune system
• (31:17) Effects on intelligence
• (34:36) Breastfeeding as a benefit to maternal health

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information on the biology of breast milk straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor