FoundMyFitness

This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the ongoing pandemic and tried to add value by talking about some of the recent research, among other things.

In this episode, you'll discover:

• (00:00) Introduction
• (04:06) Data surrounding SARS-CoV-2 duration
• (06:30) SARS-CoV-2 and long-lasting immunity
• (11:27) Genetic causes of immune variation
• (14:27) Previous viral exposure and cross-immunity to SARS-CoV-2
• (18:57) Antibody-dependent enhancement and SARS-CoV-2 relevance
• (21:50) Sleep deprivation impairs immunity & vaccine efficacy
• (23:42) Microbiome composition and immune function
• (28:22) The differential effects of exercise intensity and duration on immune regulation
• (34:10) Micronutrient inadequacies promote immune dysregulation
• (46:32) Effects of sex and age in immune regulation
• (48:59) Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19
• (52:28) ARDS and long-term lung damage

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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In this episode, Dr. Rhonda Patrick discusses all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more!

In this episode, you'll discover:

• (00:00) Introduction
• (07:33) Background on vitamin C, an antioxidant and immune booster
• (17:09) Bioavailability of vitamin C and dose frequency
• (22:53) Vitamin C in the context of the common cold
• (28:09) Vitamin C improves lung function and immunity
• (35:54) Vitamin C and exercise - does it blunt exercise adaptation?
• (45:51) Vitamin C and fatty acid oxidation, including relevance in obesity
• (48:44) Vitamin C and the brain - memory, learning, and executive function
• (51:15) Intravenous Vitamin C and its use for the treatment of certain kinds of infection
• (55:33) Intravenous Vitamin C as an adjunct cancer therapy
• (57:40) Effect of Vitamin C on fertility and reproduction
• (58:36) Intravenous vitamin C and cardiovascular health
• (01:00:42) Vitamin C and inflammation
• (01:02:38) Vitamin C's mechanisms of action
• (01:08:34) Intravenous and Oral vitamin C safety
• (01:10:20) Vitamin C intake and kidney stone risk
• (01:13:57) Conclusions

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

In this episode, Dr. Rhonda Patrick discuss all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more!

Episode Timeline (abridged)

• 00:07:33 - Background on vitamin C
• 00:17:09 - Bioavailability of vitamin C [including dosing frequency]
• 00:22:53 - Vitamin C in the context of the common cold
• 00:28:09 - Vitamin C and lung function
• 00:35:54 - Vitamin C in the context of exercise [includes discussion of blunting of exercise adaptation]
• 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity
• 00:48:44 - Vitamin C and the brain
• 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection
• 00:55:33 - Intravenous Vitamin C and cancer
• 00:57:40 - Effect of Vitamin C on fertility and reproduction
• 00:58:36 - Intravenous vitamin C and cardiovascular health
• 01:00:42 - Vitamin C and inflammation
• 01:02:38 - Vitamin C’s mechanisms of action
• 01:08:34 - Intravenous and Oral vitamin C safety
• 01:10:20 - Vitamin C intake and kidney stone risk
• 01:13:57 - Conclusions

Get the full timeline, show summary, and all references for this episode by clicking here.

View our new 28-page vitamin C overview article with over 190 references by clicking here.

Premium membership: Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support the show and get cool perks, that's the bottom line. Click here to learn more about premium membership.

This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon.

In this episode, you'll discover:

• (00:00) Introduction
• (02:37) Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission?
• (11:00) Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore?
• (17:58) Can you talk about quercetin's role as a zinc ionophore?
• (20:51) Is there any indication blood type influences COVID-19 risk?
• (24:52) Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection?
• (43:45) Can you discuss whether sauna use might help prevent COVID19?
• (52:55) Is it true that high dose intravenous vitamin C might help treat COVID-19?
• (01:04:35) What are your thoughts on melatonin being a potential factor for impacting the severity of the virus via its effects on inflammation and oxidative stress?

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon.

Some of the questions we selected from the batch to cover in this episode include:

• 00:02:36 - Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission?

• 00:11:00 - Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore?

• 00:17:58 - Can you talk about quercetin's role as a zinc ionophore?

• 00:20:51 - Is there any indication blood type influences COVID-19 risk?

• 00:24:52 - Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection?

• 00:43:45 - Can you discuss whether sauna use might help prevent COVID19?

• 00:52:55 - Is it true that high dose intravenous vitamin C might help treat COVID-19?

• 01:04:35 - What are your thoughts on melatonin being a potential factor for impacting the severity of the virus via its effects on inflammation and oxidative stress?

To supplement this podcast Q&A, we’ve also made a video, summary, timeline, and references. You can view all of these on the episodes page on my website at foundmyfitness.com/episodes/covid-19-qa-1.

If you enjoy this question & answer format, consider joining my premium membership community! Non-COVID-19 related Q&As happen monthly, you get access to an an exclusive bi-weekly science digest email, and much more more! Click here to learn about premium.

This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.

In this episode, you'll discover:

• 00:00:00 - Introduction
• 00:08:00 - Increasing omega-3 levels in the brain with phospholipid DHA
• 00:27:23 - Metformin's effects on longevity and possible harms
• 00:48:23 - Fasting and NAD+ supplementation
• 00:50:05 - Getting sulforaphane from food and supplements
• 01:06:57 - Magnesium L-threonate efficacy for brain health
• 01:13:44 - Sauna use mimics exercise, improving heart and brain health
• 01:23:48 - New FMF Membership

If you're interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/rhonda-krs-2

Join over 300,000 people and get the latest distilled information on sulforaphane research straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.

In this episode, we discuss...

• 00:08:00 - Omega-3
• 00:27:23 - Metformin
• 00:50:05 - Sulforaphane
• 01:06:57 - Magnesium L-Threonate
• 01:13:44 - Sauna
• 01:23:48 - New FMF Membership

Learn more about the new premium membership.

Learn more about sauna on our overview page.

Learn more about metformin on our overview page.

Learn more about Kevin Rose at his website or on his Twitter @kevinrose. You can also subscribe to either of his two podcasts:

• Kevin Rose Show
• Foundation by True Ventures

Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.

In this episode, you'll discover:

• (00:00) Introduction
• (03:39) Resveratrol improves cardiovascular biomarkers in clinical trials
• (06:49) Anti-inflammatory effects of resveratrol
• (08:11) Improved cognition and memory in clinical studies
• (11:23) Resveratrol improved healthspan, but not lifespan, in animals
• (12:28) Induction of longevity genes via xenohormesis
• (16:19) Contradictory effects on exercise-associated benefits
• (20:34) Various factors that affect resveratrol bioavailability
• (23:09) Unintentional effects on drug metabolism

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information on resveratrol straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.

Learn more about resveratrol at our comprehensive overview

Relevant timepoints...

• 00:03:39 - Clinical effects of resveratrol in humans
• 00:04:10 - Effects on cardiovascular health biomarkers in humans
• 00:06:54 - Reduction of inflammatory biomarkers in humans
• 00:08:11 - Improved cognition and memory in clinical studies
• 00:11:23 - Healthspan improvements in animals
• 00:12:28 - Induction of longevity genes via xenohormesis
• 00:16:19 - Contradictory effects on exercise-associated benefits
• 00:20:34 - Various factors that affect resveratrol bioavailability
• 00:23:09 - Unintentional effects on drug metabolism

Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to learn about premium.

Click here to sign-up for a three issue trial of the bi-monthly science digest.

In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. In this episode, you'll discover:

• (00:00) Introduction
• (03:07) Overview of NAD+, a source of cellular energy
• (09:18) NAD+ fuels PARP and sirtuin enzymes, promoting longevity
• (12:37) How can I raise NAD+ levels?
• (17:03) Can NAD+ boosters (NMN & NR) promote cancer growth?
• (19:15) Making sense of the research so far
• (27:03) Why not supplement with NAD+ directly?
• (29:23) Clinical trials investigating nicotinamide riboside are promising
• (32:42) Recap and concluding thoughts

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor