This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.

In this episode, we discuss...

• 00:08:00 - Omega-3
• 00:27:23 - Metformin
• 00:50:05 - Sulforaphane
• 01:06:57 - Magnesium L-Threonate
• 01:13:44 - Sauna
• 01:23:48 - New FMF Membership

Learn more about the new premium membership.

Learn more about sauna on our overview page.

Learn more about metformin on our overview page.

Learn more about Kevin Rose at his website or on his Twitter @kevinrose. You can also subscribe to either of his two podcasts:

• Kevin Rose Show
• Foundation by True Ventures

Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.

In this episode, you'll discover:

• (00:00) Introduction
• (03:39) Resveratrol improves cardiovascular biomarkers in clinical trials
• (06:49) Anti-inflammatory effects of resveratrol
• (08:11) Improved cognition and memory in clinical studies
• (11:23) Resveratrol improved healthspan, but not lifespan, in animals
• (12:28) Induction of longevity genes via xenohormesis
• (16:19) Contradictory effects on exercise-associated benefits
• (20:34) Various factors that affect resveratrol bioavailability
• (23:09) Unintentional effects on drug metabolism

If you're interested in learning more, you can read the full show notes here.

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In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.

Learn more about resveratrol at our comprehensive overview

Relevant timepoints...

• 00:03:39 - Clinical effects of resveratrol in humans
• 00:04:10 - Effects on cardiovascular health biomarkers in humans
• 00:06:54 - Reduction of inflammatory biomarkers in humans
• 00:08:11 - Improved cognition and memory in clinical studies
• 00:11:23 - Healthspan improvements in animals
• 00:12:28 - Induction of longevity genes via xenohormesis
• 00:16:19 - Contradictory effects on exercise-associated benefits
• 00:20:34 - Various factors that affect resveratrol bioavailability
• 00:23:09 - Unintentional effects on drug metabolism

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In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. In this episode, you'll discover:

• (00:00) Introduction
• (03:07) Overview of NAD+, a source of cellular energy
• (09:18) NAD+ fuels PARP and sirtuin enzymes, promoting longevity
• (12:37) How can I raise NAD+ levels?
• (17:03) Can NAD+ boosters (NMN & NR) promote cancer growth?
• (19:15) Making sense of the research so far
• (27:03) Why not supplement with NAD+ directly?
• (29:23) Clinical trials investigating nicotinamide riboside are promising
• (32:42) Recap and concluding thoughts

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, explains what the animal and human data say, discusses some of the concerns associated with using these boosters, and provides some concluding thoughts.

• Learn more about NAD+
• Learn more about nicotinamide riboside
• Learn more about nicotinamide mononucleotide
• Learn more about sirtuins

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David A. Sinclair

David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor.

Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer.

In this episode, you'll discover:

• (00:00) Introduction
• (17:59) Caloric restriction, fasting, and exercise activate sirtuin longevity genes
• (21:47) Boosting NAD+ levels reduces sirtuin loss with age
• (23:03) Resveratrol extends sirtuin activation
• (27:36) NAD+ resets epigenetic aging clocks
• (31:54) Yamanaka factors reprogram adult cells into stem cells
• (46:48) Resveratrol is a xenohormetic compound
• (55:35) Resveratrol improved cognitive function in Alzheimer's disease
• (58:03) NR and NMN improve cognitive function
• (01:06:19) NMN delays aging in multiple organs
• (01:01:22) Challenges of translating animal research

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor.

Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer.

In this episode, we discuss...

• 00:17:59 - How caloric restriction, fasting, and exercise increase levels of a molecule called NAD+ and how this activates sirtuins, a family of genes involved in longevity.
• 00:21:47 - How NAD+ levels and sirtuin activities decrease with age, and how animal studies suggest that raising cellular NAD+ levels can trick the body into thinking it is younger.
• 00:23:03 - How resveratrol enhances the binding of sirtuins to NAD+ thus making sirtuins more easily activated for a longer period.
• 00:27:36 - We also discuss Steve Horvath's epigenetic aging clock, which measures DNA methylation groups, and how they may play a role in widespread gene regulation, including sirtuin genes, and how NAD+ may participate in resetting the clock.
• 00:31:54 - How the signal that resets the epigenetic clock in mice involves the Yamanaka factors -- a group of four transcription factors that can reprogram an adult cell to become a pluripotent stem cell that can form any cell type.
• 00:46:48 - How resveratrol is a xenohormetic compound and is produced when grape plants are stressed either in response to fungus or lack of water.
• 00:55:35 - How a phase 2 clinical trial involving people with Alzheimer's disease showed resveratrol improved cognitive function, improved cerebrospinal fluid amyloid beta levels, lowered markers of activated microglia, and more.
• 00:58:03 - How both nicotinamide riboside and nicotinamide mononucleotide have been shown to improve cognitive function and brain pathology in mice that have been engineered to get a disease similar to Alzheimer's disease.
• 01:06:19 - How older mice that were given nicotinamide mononucleotide experienced delayed aging in the liver, muscle, immune cells, eyes, and bones, but those that took a lower dose had improved mitochondrial function and enhanced physical performance.
• 01:01:22 - How there may be challenges in translating animal studies on nicotinamide riboside and nicotinamide mononucleotide to humans particularly due to the need to determine the dose required to promote health benefits.
• And so much more!

Click here to get this episode's show notes and transcript

Watch this episode's highlights on the FMF Clips channel

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This podcast is the audio from a presentation Dr. Rhonda Patrick gave on how the sauna may be an exercise mimetic for heat health and healthspan. Sauna use has emerged as a means to increase lifespan and improve overall health, based on compelling data from observational, interventional, and mechanistic studies. Listen in to find out more.

In this episode, you'll discover:

• (00:00) Introduction
• (03:01) Clinical research shows that sauna improves cardiovascular health
• (09:19) Finnish sauna vs Waon infrared therapy
• (12:35) The mechanisms of sauna use mimic exercise
• (15:58) Heat shock proteins mediate the benefits of sauna use
• (23:42) Sauna use reduces inflammation
• (25:54) Sauna use is enjoyable and safe
• (28:55) Crowd questions and answers

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

This podcast is the audio from a presentation Dr. Rhonda Patrick gave on how the sauna may be an exercise mimetic for heat health and healthspan. Sauna use has emerged as a means to increase lifespan and improve overall health, based on compelling data from observational, interventional, and mechanistic studies. Listen in to find out more.

Click here to get the episode show notes and video.

Watch the episode with cardiologist and sauna scientist Dr. Jari Laukkanen.

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In this short episode, Dr. Patrick discusses some of the compelling science including observational studies, randomized controlled trials, and human mechanistic studies that suggests exercise is a powerful tool for preventing or managing the symptoms of depression and mental illness. Moreover, she talks about the specific types of exercise and exercise parameters that evidence suggests might be the most helpful for depression.

This podcast started its life as a video, so make sure to check out the full video or the references and episode notes on the episode page.

In this episode, you'll discover:

• (00:00) Introduction
• (01:51) Multiple types of research support the anti-depressant effects of exercise
• (04:45) Exercise boosts serotonin and blocks harmful kynurenine
• (10:00) Exercise causes beneficial inflammation that boosts BDNF
• (13:18) Depression lowers BDNF and neuroplasticity
• (15:08) Exercise increases endocannabinoids and endorphins
• (16:09) Concluding thoughts

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information on depression straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor