One in eight American adults have now tried a GLP-1 (Ozempic, Wegovy, Mounjaro, Zepbound). The drugs work—people lose 15-22% of their body weight in clinical trials. But new research published this month confirms what many suspected: 25-40% of that weight loss is muscle, not fat. That is catastrophic for long-term metabolic health, strength, and healthspan.

This episode breaks down the latest meta-analysis, explains why muscle loss matters (it's not just vanity—muscle is your metabolic engine, structural support, and predictor of longevity), and offers five practical steps to preserve muscle if you're on or considering GLP-1s. 

If you're considering GLP-1s, on them currently, or have an aging parent using them—this is the conversation you need to hear.

PLUS THIS WEEK'S HEALTH & FITNESS NEWS

- Mayo Clinic’s AI detects pancreatic cancer up to 3 years before clinical diagnosis

- Tick bite surge — early-season Lyme disease risk hits the Northeast

- The simple at-home strength test JAMA Network Open just linked to longevity

- The exact daily step count that prevents weight regain after dieting

- GLP-1 muscle loss — the biggest health and fitness story of the week

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The health and fitness show for everyday people.

Each week, we break down the health and fitness headlines that matter and translate them into clear, practical action. You’ll also hear conversations with trusted experts in strength training, longevity, mental health, nutrition, stress management, and parenting.

Hosted by Jesse Carrajat — USMC veteran, fitness coach, healthcare executive, and father of three.

Give us 45 minutes a week, and we’ll help you train smarter, eat better, manage stress, and build a stronger body and mind for the long haul.

Let’s grow stronger, week by week.