What role could psychedelics play in the future of headache medicine? In this episode of HeadWise, host Lindsay Weitzel, PhD, is joined by Emmanuelle Schindler, MD, PhD, to discuss the latest research on psilocybin and other psychedelics in migraine, cluster headache, and post-traumatic headache.

They explore how these compounds are being studied, what early clinical trials have found, safety considerations, and why more research is still needed before these therapies become part of routine care.

This episode is for educational purposes only and is not intended to provide medical advice. Please consult your healthcare provider regarding your individual symptoms and treatment options.

In this episode of HeadWise™, host Lindsay Weitzel, PhD, is joined by Amelia Barrett, MD to explore how emerging research on biological pathways may help explain why some people experience treatment-resistant migraine.

The conversation focuses on several actionable pathways involved in medication metabolism, methylation, and neurotransmitter function, and discusses how these processes may influence migraine, medication side effects, and treatment response. Dr. Barrett also explains how nutrition, genetics, and personalized medicine may work together to support more individualized migraine care as research continues to evolve.

This episode is for educational purposes only and is not intended to provide medical advice. Please consult your healthcare provider regarding your individual symptoms and treatment options.

In this episode, host Lindsay Weitzel, PhD, is joined by neurologist Amelia Barrett, MD, to explore the role histamine may play in migraine and headache disorders.

Dr. Barrett explains what histamine is, how it functions in the immune system, and why elevated histamine levels may contribute to headache attacks in some people. They discuss the connection between histamine, inflammation, mast cells, and migraine, along with common food sources of histamine, including fermented foods, aged cheeses, cured meats, wine, and even leftovers.

The conversation also covers histamine intolerance, the enzyme diamine oxidase (DAO), mast cell activation, cluster headache, and why certain individuals may be more sensitive to histamine than others.

This episode is for educational purposes only and is not intended to provide medical advice. Please consult your healthcare provider regarding your individual symptoms and treatment options.

In this episode, host Lindsay Weitzel, PhD, is joined by headache specialist Fred Cohen, MD, to explore one of the most common questions people ask about headache disorders: What does it mean if my head hurts in a specific location?

In this episode, host Lindsay Weitzel, PhD is joined by Tim Smith, MD and migraine clinical trial participant Tierra Lillard to explore how migraine clinical trials help advance treatment options and improve care for people living with migraine.

In this week’s episode of HeadWise, Lindsay Weitzel, PhD, and Tim Smith, MD, break down the latest migraine research news.

They discuss a new PACAP-targeting migraine treatment in development, research on exercise and migraine frequency, “false non-responders” to CGRP therapies, and new findings on THC/CBD and vaporized cannabis for migraine treatment.

Listen now for a closer look at emerging migraine research and what these studies could mean for future migraine care.

Behavioral therapies can play a key role in migraine care.

In this episode of HeadWise, Lindsay Weitzel, PhD, is joined by Dawn Buse, PhD, to break down approaches like cognitive behavioral therapy (CBT), biofeedback, relaxation training, mindfulness, and ACT. Learn how these strategies help regulate the nervous system, reduce symptoms, and improve quality of life for people living with migraine.

Blood sugar may play a bigger role in migraine disease than many people realize. In this episode of HeadWise™, host Lindsay Weitzel, PhD, and guest Laurel Short, DNP, explore how blood sugar fluctuations, insulin, and meal timing may impact headache and migraine, along with simple strategies to help keep levels more stable throughout the day.

In this episode, host Lindsay Weitzel, PhD, is joined by headache medicine specialist Fred Cohen, MD, director of Headache Intervention in New York City and assistant professor at the Icahn School of Medicine at Mount Sinai, to discuss why headache attacks commonly occur during viral illnesses like the flu, COVID, and other infections.

They explore how inflammation and immune responses during illness can trigger headache attacks, why some people experience migraine attacks when they are sick, and why headache attacks can sometimes continue even after the infection has resolved. They offer guidance on recognizing different types of headache attacks and understanding when to seek medical evaluation.