Health Longevity Secrets

DNA epigenetic methylation clocks are becoming the gold standard in longevity for determining biological [as opposed to chronological] age. 

Today we speak with Dr Yelena Budovskaya, CEO of Trume Labs that makes a consumer DNA epigenetic methylation clock for $99. Yelena obtained her Ph.D. in Molecular Genetics at Ohio State University and then studied the genetics of aging at Stanford University, leading her own research program in aging and the effects of genetics, epigenetics, and microbiome on the aging process at The University of Amsterdam.

Health Longevity Secrets show listeners who wish to try The Trume DNA methylation clock on themselves can receive a 20% discount by entering the code DRLUFKIN at the https://trumelabs.com/ website.

 #longevity #wellness  #aging #lifestylemedicine #younger  #biohacking #RobertLufkinMD #trumelabs #yelenabudovskaya #epigenetic #Biologicclock #Methylation

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Reversing DNA methylation can result in restoration of vision loss in old mice (Lu 2020).  Can human epigenetic methylation clocks be reversed using relatively straightforward lifestyle changes?  

Dr Kara Fitzgerald  is on the faculty at the Institute for Functional Medicine (IFM) and is an IFM Certified Practitioner. She received her doctorate in naturopathic medicine from the National College of Naturopathic Medicine in Portland, Oregon. Dr. Fitzgerald runs a Functional Medicine Clinic Immersion program for professionals, hosts a very popular podcast New Frontiers in Functional Medicine, and maintains an active blog on her website.  Her new book 'Younger You' is coming out in Jan 2022.  

Please join Dr Kara Fitzgerald for this masterclass in human epigenetic DNA methylation manipulation.

Take away points: 

-Increased DNA methylation age is associated with no significant net methylation change.

-~25% of methylation clock sites are related to glucocorticoid response elements underscoring the relationship of stress and aging.

—Supplemental methylation helpers (folate, b12, choline, etc) have a narrow effective range- with too little or too much having negative consequences.

-Lifestyle changes can reverse DNA methylation age in humans.

00:00 Kara's vision for reversing global epidemic of chronic disease

03:10 Appeal of naturopathic medicine as a systems model similar to functional medicine 

06:04 Value of -omics; epigenomics, metabolomics, and microbiomics

07:39 DNA methylation process and epigenetic age

11:39 No net change in methylation with aging, just rearrangement of sites

12:25 Dose response of dietary methyl donors

15:18 Horvath methylation clock used in paper

19:23 Components of the lifestyle intervention 

25:32 Effect on triglycerides

28:34 Options for vegans instead of liver as a methyl donor

32:05 Ongoing program and forthcoming book

35:05 Personal lifestyle choices

37:02 10 cups of vegetables a day, 12 hour fast per day 

38:03 Exercise, relaxation, and sleep choices 

 https://www.drkarafitzgerald.com/ 

Lu, Yuancheng, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L. Vera, et al. “Reprogramming to Recover Youthful Epigenetic Information and Restore Vision.” Nature 588, no. 7836 (December 3, 2020): 124–29. https://doi.org/10.1038/s41586-020-2975-4.

 Fitzgerald, Kara N., Romilly Hodges, Douglas Hanes, Emily Stack, David Cheishvili, Moshe Szyf, Janine Henkel, et al. “Potential Reversal of Epigenetic Age Using a Diet and Lifestyle Intervention: A Pilot Randomized Clinical Trial.” Aging 13, no. 7 (April 15, 2021): 9419–32. https://doi.org/10.18632/aging.202913.

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NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here.

Disclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel. 

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#longevity  #wellness #antiaging #biologicalage #lifestylemedicine #younger #epigenetics #biohacking  #RobertLufkinMD #Karafitzgerald

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035: Charles Whitney MD: Oral Health and Risk of Chronic Disease

It used to be that brushing your teeth was just to help prevent cavities. Now we are learning that oral disease is an independent risk factor for stroke, heart attack, Alzheimer’s disease, and some cancers.

Let’s find out why….

Charles Whitney MD is double board certified in Family Medicine and Sports Medicine. He served 7 years as an Air Force physician and 6 years in the University of Pennsylvania Health System.  

Dr. Whitney is founder of Revolutionary Health Services. Dr. Whitney served on the Board of Directors of the American Academy of Private Physicians, and was Vice President. He is currently on the speaker’s bureau of the Bale-Doneen Method of Heart Attack and Stroke Prevention, the program at the core of the RHS approach.

https://rhslivewell.com/

 #longevity #wellness  #oralhealth #lifestylemedicine #younger #ketosis #biohacking #teeth #RobertLufkinMD #charleswhitneyMD  #revolutionaryhealthservices #pgingivalis

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Therapeutic carbohydrate restriction is no longer a fringe practice and is now increasingly recognized for its value in diabetes, obesity, neurodegenerative disease, stroke, heart disease, dementia, and some cancers. Clinical guidelines and a standard of care about the practice will help accelerate this change. 

 Doug Reynolds is the Founder and CEO of LowCarbUSA® and President of the Society of Metabolic Health Practitioners(SMHP).  

The Society of Metabolic Health Practitioners (SMHP) is a non-profit for practitioners focused on metabolic health and they have a panel of advisors to oversee the creation and maintenance of a set of 'Clinical Guidelines for Therapeutic Carbohydrate Restriction’. The SMHP also helps to establish Standard of Care around carbohydrate restriction.

LowCarbUSA provides a platform for scientists and medical practitioners to present the ever-increasing body of evidence on the benefits of reducing carbohydrates in the diet and adding in healthy fats. It has now evolved into one of the primary resources for the low carb community.   

https://thesmhp.org/
https://www.lowcarbusa.org/

 #longevity #wellness  #Ketones #lifestylemedicine #younger #ketosis #biohacking #acetone #RobertLufkinMD #metabolichealth #dougreynolds  #societyofmetabolichealthpractitioners #lowcarbusa

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Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.

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SAGE: A Self Administered Cognitive Assessment

Assessment for mental status and cognition are vital if we are to spot the early warning signs of disease. The problem is if we wait until we have trouble remembering where we put the keys we may be well along the path to dementia with lots of damage done.  ​

Also as we’ve discussed in other videos, the changes of Alzheimers disease start decades before subjective cognitive impairment so tests like these will help us to create a valuable baseline to pick up any changes well before they would otherwise be diagnosed.

Today we will be looking at the SAGE exam which stands for Self-Administered Gerocognitive Examination. It is designed to detect early signs of cognitive, memory or thinking impairments.

https://wexnermedical.osu.edu/-/media/files/wexnermedical/patient-care/healthcare-services/brain-spine-neuro/memory-disorders/sage/us/sage_form1_us_2021.pdf?la=en&hash=34FD683BB99F18CA3E79A270FC750827A1DB4184 
https://wexnermedical.osu.edu/-/media/files/wexnermedical/patient-care/healthcare-services/brain-spine-neuro/memory-disorders/sage/us/sage_form2_us_2021.pdf?la=en&hash=865269D2F8B9BFDD94F96820D45539711DCC8293 
https://wexnermedical.osu.edu/-/media/files/wexnermedical/patient-care/healthcare-services/brain-spine-neuro/memory-disorders/sage/us/sage_form3_us_2021.pdf?la=en&hash=AA4D168E2EE68E6EE37ACD9D96F788DD096C8CFF 
https://wexnermedical.osu.edu/-/media/files/wexnermedical/patient-care/healthcare-services/brain-spine-neuro/memory-disorders/sage/us/sage_form4_us_2021.pdf?la=en&hash=AA86EF19B1DC117200DF4561F54D552FB6D9926E 

#SAGE #wellness  #dementia #lifestylemedicine #younger #biohacking #RobertLufkinMD  #alzheimers  #cognitive

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How  can we use genetics to increase our health and longevity? Find out as we speak with Islam Mansour, Co-Founder and CEO of MyGenomd.com. He has a Bachelors in Bioinformatics from the Technical University of Munich.

Take away points: 

-Pharmacogenetics has potential to identify gene-drug interactions which can affect the metabolism and bioavailability a drug.

-Mental health is an under appreciated area for genetic risk factor identification although the challenges are significant

-Privacy and regulatory issues remain a significant hurdle for companies seeking to develop products and services in the genomics splace

-The mygenomd.com service is currently available in beta at no charge for those interested in exploring their own genetic risk profile.

https://mygenomd.com/ 

https://www.headspace.com/ 

 #longevity #wellness  #Ketones #lifestylemedicine #younger #ketosis #biohacking #acetone #RobertLufkinMD #mansour #genetics 

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Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.

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031: Can a Ketogenic Diet Reverse Chronic Disease? Today we find out from Doctor Vyvyane Loh, Founder  of the Transform Alliance for Health and board-certified in Obesity Medicine and Internal Medicine . She graduated from Boston University School of Medicine and trained at Newton-Wellesley Hospital.
Unlike most physicians on our program or anywhere she is also an accomplished choreographer and fiction author who won the Bunting/Radcliffe Fellowship in Fiction in 2006, a Guggenheim Fellowship in Fiction in 2008, and was shortlisted for the 2005 international IMPAC Award in Literature.

https://www.transform-afh.com/

 #longevity #wellness  #Ketones #lifestylemedicine #younger #ketosis #biohacking #acetone #RobertLufkinMD #vyvyanelohMD #chronicdisease 

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029- An important risk factor for Alzheimer’s disease is head trauma and the chronic traumatic encephalopathy that can result. It is causing us to rethink everything from  how we view high school tackle football consideration to whether headers should be allowed in high school soccer play.

Michael Alosco PhD is co-director of the Boston University Alzheimer’s Disease Research Center Clinical Core. He completed his undergraduate studies at Providence College and he earned his doctoral degree in clinical psychology from Kent State University. He is an Associate Professor of Neurology at the Boston University School of Medicine. Dr. Alosco has >150 peer-reviewed publications.

 #longevity #wellness  #Ketones #lifestylemedicine #younger #ketosis #biohacking #acetone #RobertLufkinMD #michaelalosco #football #CTE

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Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.

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029- If you or a loved one is battling Alzheimer’s or other dementia, or if you want to know how to prevent this disease from destroying your life, then register now to watch all 25 interviews in this Free 8-day online video series event. By the conclusion of the event, you’ll know how to create an Alzheimer’s and dementia-free future for your entire family, for generations to come.      Again, the best part is, it’s totally free.  

 Please join us over the next 8 days starting November 29 we will hear from 25 experts about how we can best prevent Alzheimer's disease in ourselves, our loved ones, and anyone else who will listen.

https://www.robertlufkinmd.com/alzheimerprevention/

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CT calcium score is usually thought of as a test for heart disease but did you know it is also for Alzheimer’s disease, diabetes, stroke, cancer and other chronic diseases? Stay tuned and we’ll find out why. This talk is dedicated to my friend Steve who was thin and healthy and decided to get a CT calcium score- we’ll come back to what happened to him in a bit. 

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