High Intensity Health with Mike Mutzel, MS

By Mike Mutzel shares interviews with Peter Attia, Jason Fung, Stan Efferding,

High Intensity Health features breakthrough health tips and hacks from respected authorities in the Fitness, Nutrition and Functional Medicine fields. Our expert guests have shared insider information... more

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The podcast currently has 644 episodes available.

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Number 1: 4 Strategies to Prevent Overeating, Especially at Night
Overeating, especially at night, can lead to fat and weight gain. We review some practical tips to help prevent the over-consumption of food and special considerations during the holiday season. Why you eat what you eat book: https://amzn.to/3FpbrK6 Eat Like Your Life Depends on it Tee Shirt: http://bit.ly/myoxcience Save on your Omega-3 Index Test by MYOXCIENCE Nutrition: http://bit.ly/omega-3-index Use code Podcast at checkout
December 27, 20216min
Number 2: Look Younger, Slow Aging with These 5 Overlooked Habits (new bombshell Circadian Rhythm science)
New science suggests circadian rhythms, sleep cycles and meal times powerfully influence how you age. As boring as it sounds, being a creature of habit and minding your circadian rhythms may be among the top ways to optimize the biology of aging. Save on MYOXCIENCE Nutrition's new Electrolyte Stix: *Buy one get one 50% OFF ends January 21st, 2022 Link to Show Notes and Research: https://bit.ly/3Kh38TC 00:36 As we age our circadian rhythm becomes altered. Phenotypes of ageing: wrinkles, gray hair, decline in function, muscle mass loss, metabolic disease, high blood pressure, insulin resistance, sleeplessness and alterations in sleep/wake cycles, can be the result decreased amplitude and intensity of your circadian clock system. 01:24 Be vigilant about your sleep and wake times and meal timing. Food influences your body’s peripheral circadian clock system, which provides feedback to the central clock system. 03:13 Your circadian clock system is intimately connected with your metabolism and the rate at which you age. 03:26 Take screens out of your bedroom. Go to bed at the same time every night. Be strict. 06:52 Be consistent with your meal timing. Your body has a second meal effect and is anticipating food at your regular mealtime. Food and exercise influence your peripheral circadian clock system. 08:26 Your metabolism, nutrient sensing enzymes and receptors are improved with exercise, fasting and low carb diets. These enzymes and receptors influence the circadian clock system. 09:16 Poor sleep negatively impacts metabolic health. Improving your metabolic health works to improve imbalances in the circadian clock system, which improves sleep, which improves metabolic health. Night shift workers have higher rates of obesity, diabetes, high blood pressure and cancer. 10:41 The ageing phenotypes that you express at the end of your life, is connected to the health of your circadian clock system. 11:56 Take blood sugar support supplements later in the day when you are more insulin resistant. 12:31 Chrononutrition and chronopharmacology utilizes genetic and metabolomic analysis to determine timing of cancer drugs. Your immune system is more active earlier in the day. 14:51 Light exposure in the evening, not just blue light, alters the function of your circadian clock rhythm. Match your light exposure to that of your outdoor environment. 17:40 Children are more sensitive to light exposure, especially at night. They have a greater degree of melatonin suppression when they are exposed to light. Screens at night for children accelerates their ageing, alters their metabolism, alters insulin metabolism, causes cravings of junk food, alters behavior, and impacts memory, sleep quality, and facial development. 18:51 Invest in a pair of blue light filtering glasses. Mike prefers BLUblox. References Sato, S., (2021). Tuning up an aged clock: Circadian clock regulation in metabolism and aging. Translational Medicine of Aging, 1–42.
January 15, 202223min
Number 3: High Cholesterol Freaks Doctors Out, Use this ApoB Test Instead
Standard lipid panels are actually mathematical approximations. Emerging data suggests using the very affordable ApoB to ApoA1 ratio more accurately assess cardiometabolic disease risk. Save on your Omega-3 Index Test by MYOXCIENCE Nutrition: https://bit.ly/omega-3-index Use code Podcast at checkout Download the bloodwork cheatsheet: https://bit.ly/3dyy4zM Enroll in the Blood Work MasterClass Time Stamps 0:45 ApoB why it’s more accurate 1:30 High LDL on a ketogenic diet 2:24 Heart disease deaths increase in the winter 2:59 High LDL after fasted exercise 4:50 What ApoB means and why it matters 7:15 Why Omega-6 seed oils are bad if your LDL is high 9:11 Request your ApoB to A1 ratio instead 9:38 Standard cholesterol tests are a mathematical estimate 12:06: HDL and ApoA-1, how it’s cardioprotective 12:45 Harvard case study of LDL increases on a Keto diet 19:25 Advanced lipoprotein particle testing overview
December 23, 202125min
Number 4: APOE Gene, Alzheimer’s & Dementia Disease Risk: Must Know New Details
Alzheimer’s disease and dementia prevalence and deaths are on the rise, claiming over 6,000 lives in the USA every week! Yet many people don’t even know their APOE genotype, which arguably has the biggest impact on future Alzheimer’s disease and dementia as well as cardiovascular disease risk. In this show we dive deeper into what the APOE gene does and how knowing this info can help tweak your nutrition and lifestyle helping to reduce risk of future disease—especially if you have one or two copies of the APOE ε4 gene. Save on your Omega-3 Index Test by MYOXCIENCE Nutrition: http://bit.ly/omega-3-index Use code Podcast at checkout Link to Video + Show Notes: https://bit.ly/apoe-gene-alzheimers Eat Like Your Life Depends on it Tee Shirt: http://bit.ly/myoxcience Enroll in the Blood Work MasterClass: https://bit.ly/blood-work-masterclass Time Stamps: 0:00 Intro 00:53 APOE is a gene that makes proteins that are involved in lipid binding. 01:10 APOE and Immunity 01:39 APOE 4 alleles and Alzheimer’s disease risk 03:13 3 different APOE isoforms: APOE2, APOE3, APOE4 allele. 03:44 Having the gene does not mean that you will get the disease. 04:35 APOE is involved in lipid metabolism 05:30 Lipoproteins and lipids transport 06:05 APOE can redistribute lipids across tissues and cell types. 07:40 APOE is secreted by the liver with VLDL and bile acids 08:00 Lipoprotein lipase facilitates your metabolic deposits. Hormone sensitive lipase facilitates your metabolic withdrawals. 09:42 Your omega 3 index and APE 4 isoform. 11:35 APOE4 and cholesterol 11:45 ApoB VS ApoE 12:09 APOE2 carriers tend to have a less atherogenic lipid profile. 12:15 APOE4 carriers are associated with decreased levels of APOE triglycerides and increased levels of APOB in lipoproteins 13:12 APOE4 puts genotype carriers at increased risk for heart disease. This is likely due to the association with APOE4 and elevated LDL and Apolipoprotein B. 14:07 APOE4 primes your microglia to be more inflammatory. Microglia are brain immune cells. They are involved in synaptic processing, pruning of cells, shaping neurons, and removing inflammatory debris. APOE4 carriers have decreased cerebral glucose metabolism and increased levels of beta amyloid and tau protein. 15:50 With APOE4, there are changes and increase of tau protein within the neurons. There are also alterations in the blood brain barrier integrity. 16:00 To preserve the integrity of the brain, moderate alcohol consumption, increase exercise, incorporate sauna therapy and sauna bathing, as it effects cerebral blood flow. 16:45 APOE is expressed in astrocytes, microglia and other vascular cells within the brain. Blood brain barrier prevents toxins and metabolic waste from going into your brain. Increased expression of APOE is detected in stressed neurons. 17:42 APOE isoforms affect lipid transport, glucose metabolism, mitochondrial function, synaptic plasticity, beta amyloid protein expression, tau protein and cerebral vascular function within the brain. 18:18 Ratio of APOE4 allele correlates with loss of gray matter volume and abnormal glucose metabolism, a hallmark of Alzheimer’s and dementia. 19:00 APOE4 is the greatest genetic risk factor for late onset Alzheimer’s disease. It also influences the risk and outcomes for stroke, MS, Parkinson’s disease, and frontotemporal dementia. 22:11 A low carb diet, high in wild caught fish, is protective for APOE4 carriers. It impacts brain metabolism and lipid levels favorably. Drive your glycemic load down. 24:05 If you are over the age of 50 and have one or two copies of the APOE4 allele, consider microdosing with rapamycin. Rapamycin is an mTOR inhibitor. It may delay the onset of Alzheimer’s and dementia.
December 29, 202128min
Number 5: Top 2020 Conspiracy Theories That Turned Out to be True
“We don’t have time to get healthy…Being fit and not having diabetes or underlying health conditions won’t help you against this ‘new’ virus,” they said. Well, it turns out many of the ideas we shared in 2020 are now true and being healthy is no longer a conspiracy, data shows. Hope you enjoy this breakdown! Save on MYOXCIENCE Nutrition's new Electrolye Stix: *Buy one get one 50% OFF ends January 19th, 2022 Link: https://bit.ly/electrolyte-stix Link to the video and notes: https://bit.ly/3JYOnEK Time Stamps: 0:01 Intro: summary of unrealistic expectations created by the media that have destroyed careers, relationships and trust in our institutions LINK: COVID-positive nurses say they're being pressured to work while sick, and they're petrified of infecting patients 10:25 #1 Everyone’s risk of dying is the same. About 80% of COVID 19 deaths in the USA occurred in individuals over the age of 65. 13:55 #2 Nutrition and exercise have nothing to do with the virus. 17:05 #3 Use cases to gauge the trajectory of the pandemic. 19:05 #4 Mandates and restrictions are the solution. NYC, LA and Seattle are leading the nation in new cases, proving that restrictions do not work. 14:40 #5 We don’t have time to get healthy. 28:18 #6 All masks are equally effective. We know this is not the case. 30:00 #7 Media fear mongering does no harm. 33:23 #8 The indirect effects of COVID to young people are less harmful than the direct effects of COVID. 36:29 #10 The virus is going to be eradicated, just like smallpox and polio. 38:39 #11 Promoting healthy living causes vaccine hesitancy. 430:19 #12 “Natural immunity is not durable,” they said. Wrong 42:25 #13 People in the hospital are there because they have COVID. 43:50 #14 Closing fitness centers and gyms will help flatten the curve. 34:59 #15 Closing schools is a good idea. School can be an escape from abuse for some children. 46:25 #15.5 Lockdowns were necessary. The virus was spreading months before lockdowns were implemented. It was not going to be kept out. There were many unintended harms. 47:54 #16 Voter ID is racist, but a vaccine passport is equitable. Selective policies apply in one context but not others. 49:30 Public health is designed to maximize the quality adjusted life years of a population. Link to the video and notes: https://bit.ly/3JYOnEK
January 11, 202254min