Hormones, Metabolism & You!

By Cassie Smith

Your hormones control everything—from energy levels to weight, mood, and overall health. But understanding them shouldn’t feel like decoding a medical textbook. Welcome to Hormones, Metaboli... more

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FAQs about Hormones, Metabolism & You!:

How many episodes does Hormones, Metabolism & You! have?

The podcast currently has 100 episodes available.

Hormones, Metabolism & You! episodes:

March 01, 2026 100: The Most-Shared Episodes on Thyroid, Hormones & Fatigue — The Answers Your Doctor Isn’t Giving You
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In this special 100th episode of Hormones, Metabolism, and You, Dr. Cassie Smith celebrates the milestone with a best-of compilation featuring some of the most downloaded and impactful conversations from the show. Each segment reflects a powerful truth listeners continue to come back to: when you feel off, there is usually a biological reason, and real answers start with understanding the root cause.
You will hear highlights from key conversations, including:
Tamar Samuels: Debunking common nutrition myths and social media trends, including restrictive “one-food” weight loss approaches and the confusion around anti-diet culture. This segment emphasizes personalized nutrition, metabolic health, and the importance of sustainable habits that support both body composition and long-term health.
Terri DeNeui: A powerful discussion on hormone therapy in your 30s, 40s, and 50s, including the truth about estrogen and cancer risk. This segment breaks down the long-term misunderstanding from the Women’s Health Initiative and explains why timing, personalization, and proper hormone support are critical for brain, heart, bone, and overall longevity.
Dr. Bruce Hoffman: A deep dive into chronic fatigue, mitochondrial dysfunction, and the concept of the cell danger response. You will learn why energy production is central to healing and how factors like toxic load, circadian rhythm, sunlight exposure, hydration, and lifestyle habits directly influence mitochondrial health and recovery.
Dr. Cassie Smith (Solo): A practical breakdown of thyroid optimization, including ideal functional ranges for TSH, Free T4, Free T3, Reverse T3, and thyroid antibodies. This segment explains why symptoms matter more than standard lab ranges and how inflammation, gut health, stress, and cellular function affect thyroid hormone activity.
Dr. Tyna Moore: An insightful conversation on GLP-1 microdosing and peptide therapy beyond weight loss. This segment explores how low-dose GLP-1s can support brain health, inflammation, metabolic function, and longevity, while also highlighting the importance of gut health, hormone balance, and foundational lifestyle habits before using advanced therapies.
Together, these listener-favorite moments reinforce the core message of the show: you are not broken, your symptoms are not random, and lasting change happens when you address the biology behind the symptoms.
Key Takeaways
This special 100th episode highlights a core theme across listener favorites: when symptoms don’t match normal labs, the issue is often deeper biology, not willpower. Sustainable health requires personalized nutrition, strong lifestyle foundations, and attention to real markers, not trends or extremes. Hormone therapy fears are often based on outdated information, thyroid care goes beyond TSH alone, and tools like GLP-1s work best as supportive therapies, not shortcuts. The consistent message throughout is safety-first, root-cause care with the right intervention at the right time.

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53min
February 22, 202699: Thinking About Peptide Therapy or GLP-1s? A Physician’s Safety Checklist for Women in Perimenopause & Menopause
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What if peptides and GLP-1s are not the problem, but the internet hype is making it impossible to know what is actually safe, effective, and worth your money?
In this episode of Hormones, Metabolism, and You, Dr. Cassie Smith sits down with Greg Jones, NMD to cut through the confusion around peptides, GLP-1s, microdosing, stacking, and the next wave of weight loss medications. Dr. Jones explains why lifestyle is the foundation (there is no magic shot), outlines red flags for online prescribing and questionable sourcing, and compares newer multi-agonists like retatrutide with semaglutide and tirzepatide. You will also learn how to manage common issues like nausea, reflux, constipation, fatigue, and plateaus, and why safety-first, individualized care with proper monitoring matters most.
Key Takeaways
Healing and body composition start with the foundation: nutrition, hydration, sleep, and resistance training
Peptides fall into different categories: some affect feedback loops and require more monitoring, others are used more directly by the body

GLP-1 dosing should be individualized; aggressive titration increases side effects and long-term risks

Retatrutide is a triple agonist (GLP-1, GIP, glucagon) and may increase energy expenditure, but appetite and food noise can vary by person

Side effects often improve when diet, alcohol intake, and hydration are addressed

Weight loss should be gradual to help preserve lean mass and reduce skin laxity issues

Exit strategies should be personalized: taper dose, extend dosing intervals, and keep the habits in place

When the shots go away, the habits need to stay
Episode Highlights
Why the foundation matters: “trash in, trash out” and why sleep plus strength training drive long-term results

Red flag checklist for online prescribing: no labs, no check-ins, “not for human use” labeling, and three-month scripts with no monitoring

What to monitor with GLP-1s and related therapies, including why baseline labs matter

Retatrutide vs tirzepatide vs semaglutide: what is different, what is promising, and what is still evolving

Real-world GLP-1 troubleshooting: reflux, constipation, fatigue, nausea, and why microdosing can change tolerance

Why plateaus happen and how to adjust safely without overcorrecting

Who is at highest risk for muscle loss during fat loss and how to protect lean mass in midlife

Growth-hormone-related peptides explained: CJC-1295, ipamorelin, tesamorelin, and what realistic goals look like

Why “stacks” can be risky, when combinations may be acceptable, and why dosing flexibility matters

Lightning round: the biggest plateau driver, perimenopause myths, and the single best habit for preserving muscle
Connect with Greg Jones, NMD
🌐 Website: https://enovativewellness.com/dr-greg-jones/
💼 LinkedIn: https://www.linkedin.com/in/drgregjones/
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1h 7min
February 15, 202698: Perimenopause: The Gift We Didn’t Ask For and the Health Upgrade We Needed
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What if perimenopause is not your body breaking down, but your body revealing exactly what it needs to function better?
In this episode of Hormones, Metabolism, and You, Dr. Cassie Smith sits down with Bria Gadd, known as The Period Whisperer, to reframe perimenopause as a powerful turning point rather than a decline. They discuss why symptoms like fatigue, sleep disruption, anxiety, stubborn weight gain, cravings, and loss of motivation often reflect an energy deficit and accumulated “health debt,” not a lack of discipline. You will learn how years of stress, overtraining, underfueling, and pushing through exhaustion can create survival mode physiology, why traditional diet and fitness strategies often stop working in midlife, and how small shifts in recovery, nourishment, gut health, and thyroid support can help restore your baseline so your body can feel safe enough to regulate again.
Key Takeaways
Perimenopause symptoms often reflect accumulated stress and energy depletion rather than sudden hormonal failure

The “Perimenopause Gift” is your body signaling that current habits are no longer sustainable

Health debt builds over time when stress, under-recovery, and under-fueling exceed your body’s capacity

When the body is in survival mode, it may hold weight, increase cravings, and slow metabolism

More intensity in workouts or stricter dieting often increases stress hormones and worsens symptoms

Recovery, mobility, walking, and nervous system support often need to come before high-intensity training

Gut health plays an important role in hormone metabolism, nutrient absorption, and inflammation balance

Thyroid symptoms are often overlooked, and a full thyroid panel may be necessary when symptoms persist

Food noise and sugar cravings can signal energy deficiency, not lack of willpower

Sustainable progress comes from rebuilding energy and resilience rather than pushing harder
Episode Highlights
Why many women feel like their body “changed the rules overnight” during perimenopause

The energy supply vs. energy demand model and how it affects hormones, metabolism, and mood

How years of high stress, perfectionism, and overperformance contribute to midlife hormone struggles

Why strength training should be supported with adequate fuel, recovery, and nervous system balance

The connection between gut health and proper estrogen clearance

Early signs of thyroid dysfunction that are often dismissed as “normal aging”

Simple daily habits that help rebuild baseline energy, including hydration, walking after meals, and intentional rest

Why joy, presence, and reducing pressure can improve physiology, not just mindset

Bria’s practical framework for getting out of health debt and restoring long-term metabolic resilience

Connect with Bria Gadd
🌐 Website: https://www.briatheperiodwhisperer.com/
🔗 LinkedIn: https://www.linkedin.com/in/bria-gadd/
📸 Instagram: https://www.instagram.com/bria_period_whisperer/
🎧 Podcast: The Period Whisperer
📲 Follow Dr. Cassie Smith & Modern Endocrine
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1h 1min
February 08, 202697: Why Your Brain Must Feel Safe Before Detox Works: The Neurotoxic Loop of Trauma and Toxins
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<<
What if chronic illness protocols stall not because you are doing something wrong, but because your body does not feel safe enough to heal?
In this episode of Hormones, Metabolism, and You, Dr. Cassie Smith sits down with Dr. Jabin Moore to unpack why so many chronic illness protocols stall even when you are doing “everything right.” They explain how the brain prioritizes survival over repair when the body does not feel safe, and how stress, trauma, mold, Lyme, infections, and gut dysfunction can run the same threat pathways in the body. You will hear the unforgettable “$100 energy bill” metaphor, learn why detox can backfire when the nervous system is dysregulated, and get practical ways to create real safety in your environment and your biology so healing can finally stick.
Key Takeaways
Healing does not happen when your nervous system is stuck in fight or flight

Safety is biological, not just emotional, and it shapes detox, digestion, hormones, and immune function

The “$100 energy bill” explains why chronic illness creates daily energy debt and no healing margin

Toxins, infections, and trauma can activate overlapping inflammatory and survival pathways

You often need a two-pronged approach: calm the brain while clearing the body

More protocols are not always better; too much “good” can overload an already depleted system

Start with the basics: safe air, safe water, safe food, then regulate the nervous system

Simple nervous system resets can work, even five minutes of stillness and nature exposure

Protein matters because low protein can worsen stress physiology and recovery capacity

A sustainable plan protects your energy instead of burning it all on performance or perfection
Episode Highlights
Why the brain can block detox, immune regulation, digestion, and cellular repair when it senses threat

Mold, Lyme, PTSD, chronic stress, and gut issues: why they can “speak the same language” in the body

The detox myth: you cannot force clearing without first shifting out of threat mode

How perfectionism and people-pleasing can drain energy and slow recovery

The difference between living in a safe environment and actually feeling safe in it

What nervous system work can look like in real life, including limbic retraining tools

Dr. Moore’s practical framework: safe environment, safe feeling, then advanced protocols
Connect with Dr. Jabin Moore
🌐 Facebook: https://www.facebook.com/redefiningwellnesskc

📸 Instagram: https://www.instagram.com/drjabanmoore/

🎵 TikTok: https://www.tiktok.com/@drjabanmoore_

▶️ YouTube: http://www.youtube.com/@DrJabanMoore
📲 Follow Dr. Cassie Smith & Modern Endocrine
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1h 4min
February 01, 202696: Ayurveda for Perimenopause & Menopause: Gut Health, Estrobolome Support, and Anti-Inflammatory Spices
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<<
What if brain fog, bloating, exhaustion, and hormonal chaos are not separate problems, but signals of one shared root issue? In this episode of Hormones, Metabolism, and You, Dr. Cassie Smith is joined by returning guest Dr. Shivani Gupta, Ayurvedic practitioner, turmeric researcher, and author of The Inflammation Code.
Together, they explore how chronic inflammation quietly disrupts gut health, hormone metabolism, sleep, mood, and energy, especially during perimenopause and menopause. Dr. Gupta explains how ancient Ayurvedic principles align with modern functional medicine, offering practical, non-diet strategies to support digestion, estrogen metabolism, circadian rhythms, and nervous system balance.
This conversation focuses on working with the body rather than against it, using daily rhythms, simple rituals, and gut-forward practices to support long-term resilience at every stage of life.
Key Topics Covered
How chronic inflammation can drive brain fog, bloating, fatigue, and hormonal symptoms

The gut–hormone axis and why digestion is central to estrogen metabolism and mood

Ayurvedic “digestive fire” (agni) and how modern habits weaken it

Why perimenopause and menopause represent a Vata (air and ether) phase of life

Early signs of hormonal transition beyond hot flashes, including anxiety, dryness, and sleep disruption

How circadian rhythms influence inflammation, hormone balance, and metabolic health

Food-first strategies to support estrogen metabolism and reduce bloating

Why how and when you eat may matter as much as what you eat

The role of gut testing and microbiome balance in long-term healing

Super spices as medicine: turmeric, ginger, cumin, coriander, and fennel

Why healing does not require extreme diets or rigid routines

Building personalized, sustainable self-care rituals that actually stick
Key Takeaways
Chronic inflammation often connects gut symptoms, hormone imbalance, fatigue, and brain fog

Perimenopause and menopause represent a natural shift that requires more grounding and rhythm, not more pushing

Gut health plays a central role in estrogen metabolism, mood, and overall resilience

Circadian alignment supports inflammation reduction and nervous system balance

Small, consistent rituals are often more powerful than complex protocols

Spices like turmeric and ginger can support digestion and inflammation when used consistently

Healing is individualized and works best when aligned with your body’s natural rhythms
Resources & Links
🌐 Website: https://www.shivanigupta.com

📘 Book: The Inflammation Code (Hay House, February 2026)
https://www.theinflammationcode.com

🎙️ Fusionary Health Podcast
📲 Instagram: https://instagram.com/dr.shivanigupta

📘 Facebook: https://www.facebook.com/theshivanigupta

▶️ YouTube: https://www.youtube.com/@dr.shivanigupta
📲 Follow Dr. Cassie Smith & Modern Endocrine
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➡️ Disclaimer:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modernendocrineokc.com/disclaimer-6353⁠
...more
1h 3min
January 25, 202695: Why Dieting Fails in Midlife: Hormones, Insulin Resistance + Peptide Therapy
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<<
Doing Everything Right but Still Not Losing Weight? - The Shocking Truth About Midlife Metabolism - Learn How Hormones and Peptides Can Finally Unlock Fat Loss Without More Willpower
If you feel like you are eating clean, working out, staying consistent, and your body still will not respond, you are not alone. In this episode, Dr. Cassie Smith sits down with Dr. Aleksandra Gajer, M.D., to explore why weight loss resistance often shows up in midlife and why it is rarely about willpower.
They unpack how hormones, sleep, stress, inflammation, and insulin resistance can combine to slow progress, and how peptides can be used as strategic tools when they are properly prescribed, sourced, and monitored. You will also hear a practical breakdown of peptide categories, plus an important safety conversation about avoiding online sourcing and quick clinic prescribing.
Key Topics Covered
Why traditional dieting often fails for high achieving women in midlife

How shifting hormones can influence insulin resistance, metabolism, and body composition

The role inflammation can play in fatigue, weight gain, and brain fog

Why real food fundamentals still matter even with advanced therapies

What peptides are and how they differ from typical medications in the body

A simple framework: five peptide categories used in clinical practice

Metabolic peptides: GLP 1 therapies, MOTS c, and growth hormone promoting peptides

Recovery and inflammation peptides: BPC 157 and the use of KPV for gut and immune balance

Cognitive peptides discussed: Selank and Semax, plus sleep support with DSIP

Longevity focused peptides: Epitalon, plus discussion of NAD and SS 31

Aesthetic peptide overview: GHK Cu and why formulation and tolerability matter

Why peptide stacks can be less effective and harder to troubleshoot

The importance of medical oversight, safe sourcing, and individualized dosing

Free lever for better health: sleep and boundaries around screens
Connect with Dr. Aleksandra Gajer, M.D
Website: https://thegajerpractice.com/

LinkedIn: https://www.linkedin.com/in/aleksandra-gajer-md/
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1h 6min
January 18, 202694: Your Labs Are Normal but You Feel Awful - The Hidden Gut Inflammation Blocking Hormone Healing with Josh Dech
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<<
What if your lingering thyroid and hormone symptoms aren’t a lab problem at all, but a gut inflammation issue hiding beneath “normal” results?
In this episode of Hormones, Metabolism, and You, Dr. Cassie Smith sits down with holistic nutritionist and physician consultant Josh Dech to explore a core idea many patients never hear: your thyroid and hormone symptoms may be driven by hidden gut inflammation, even when labs look “normal.” Josh explains how gut dysfunction can interfere with hormone signaling, disrupt metabolism, and fuel chronic fatigue, brain fog, and stubborn symptoms. They also discuss common root drivers like toxins, infections, nutrient deficiencies, poor sleep, and chronic stress, plus practical steps to support healing without extreme protocols.
Key Topics Covered
Why thyroid and hormone symptoms can persist even with “normal” lab results

How gut inflammation can block hormone signaling and contribute to fatigue and brain fog

Gut health on a spectrum: from mild symptoms to severe inflammatory conditions

The “why” behind symptoms vs. labels and diagnoses

Mold and environmental exposures as potential hidden drivers for some people

The “three buckets” framework: toxins, microbes, and deficiencies

The role of sleep, stress, and lifestyle in gut and immune function

Why some “healthy” foods can still be personal triggers for certain individuals

Supporting drainage and detox pathways as part of recovery

Simple, sustainable steps for improving gut and overall health
About the Guest
Josh Dech is a Holistic Nutritionist and Physician Consultant specializing in Crohn’s disease, ulcerative colitis, and severe IBS. He is known for helping reverse over 400 cases of Crohn’s and colitis through a root-cause, holistic approach to gut health, conditions long considered irreversible within conventional care.
Josh has worked alongside some of the world’s most respected medical professionals and has become a trusted educator in the field of digestive and autoimmune health. He hosts a globally ranked top 2 percent podcast, has appeared on international television, and currently serves as a medical lecturer for Priority Health Academy.
Today, Josh focuses on educating both physicians and the public on integrative, evidence-informed strategies for healing chronic digestive diseases and restoring long-term gut health.
Connect with Josh Dech
Facebook: https://www.facebook.com/JoshDech
Instagram: https://www.instagram.com/joshdech.health/
YouTube: https://www.youtube.com/@joshdech
📲 Follow Dr. Cassie Smith & Modern Endocrine
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1h 15min
January 11, 202693: Why You Can’t Lose Weight (It’s Your Hormones, Not Your Willpower)
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<<
What if weight loss isn’t about discipline, motivation, or trying harder, but about understanding what your hormones are actually doing?
In this powerful New Year mash-up episode of Hormones, Metabolism, and You, Dr. Cassie Smith brings together the most impactful insights from three standout conversations to explain why traditional diets fail so many women and what truly supports sustainable weight loss.
Drawing from expert guidance by Tamar Samuels, Shana Hussin, and Terri DeNeui, this episode reframes weight gain as a hormonal and metabolic signal, not a personal failure.
Listeners will learn how stress, gut health, insulin resistance, PCOS, thyroid dysfunction, and age-related hormone shifts quietly sabotage fat loss, and why fasting, restriction, and one-size-fits-all diets often make things worse.
This episode is especially for women in their 30s, 40s, and 50s who feel stuck, exhausted, and frustrated despite doing “all the right things.”
Episode Highlights
Why weight gain is often driven by hormones, not willpower

How cortisol, leptin, insulin, and thyroid hormones block fat loss

What really changes hormonally in your 30s, 40s, and 50s

Why testosterone and progesterone decline earlier than most women realize

The truth about fasting and why it backfires for stressed women

How gut health directly affects metabolism and hormone balance

Why PCOS, thyroid issues, and insulin resistance require targeted nutrition

How restrictive diets and under-eating damage hormones long term

Why protein needs increase with age and how much women actually need

Why the scale lies and what markers matter more than weight
Key Topics Covered
It’s Not Your Fault: Understanding Hormone Shifts
Hormonal changes begin earlier than menopause

Testosterone loss affects muscle, mood, metabolism, and energy

Progesterone decline impacts sleep, stress tolerance, and fat storage

Weight gain is often a biological response, not a behavior issue
The Hidden Conditions Blocking Weight Loss
PCOS, thyroid dysfunction, and insulin resistance explained simply

How cortisol and chronic stress stop fat burning

Why leptin resistance develops from dieting and fasting

Why blood sugar balance matters more than calorie counting
Food as Medicine, Not Punishment
Why personalized nutrition beats rigid diet rules

Protein targets for women as they age

The real role of carbs and fats in hormone health

Why meal timing and eating enough matters
Lifestyle Changes That Actually Work
Circadian rhythm alignment and stress reduction

Gut health as the foundation of hormone metabolism

Why extreme fasting, overtraining, and restriction do harm

Root-cause care vs symptom suppression
Final Takeaway
This New Year, the answer isn’t another diet, cleanse, or restriction plan.
Sustainable weight loss happens when you:
Support your hormones

Heal your gut

Eat enough of the right foods

Reduce stress

Stop fighting your biology
Your body isn’t broken. It’s communicating.
📲 Follow Dr. Cassie Smith & Modern Endocrine
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52min
January 04, 202692: Your Hormones Aren’t the Problem - The Shocking Root Cause Behind Fatigue, Weight Gain, and Brain Fog with Dr. Kelly McCann
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<<
What if your hormone symptoms aren’t a hormone problem at all, but warning signs of deeper toxic, gut, and immune stress your body has been carrying for years?
In this powerful episode of Hormones Metabolism in You, Dr. Cassie Smith sits down with Dr. Kelly K. McCann, MD, to unpack why hormone symptoms like fatigue, weight gain, brain fog, mood changes, and stubborn metabolic dysfunction are often not hormone problems at all.
Instead, Dr. McCann explains how these symptoms are signals pointing to deeper root causes such as environmental toxin exposure, mold, gut dysfunction, immune dysregulation, and chronic inflammation. Together, they challenge the conventional approach of treating hormones in isolation and highlight why normal lab results do not always mean the body is functioning optimally.
This conversation explores how everyday exposures from water contamination and plastics to non-stick cookware, pesticides, and personal care products can silently disrupt thyroid function, metabolism, and hormone signaling. The episode also dives into the critical gut hormone immune connection, mold related illness, nutrient depletion, mitochondrial dysfunction, and the concept of the cell danger response.
About the Guest
Dr. Kelly K. McCann, MD is a board certified physician trained in internal medicine and pediatrics, with advanced training in integrative and functional medicine. Her work focuses on the impact of environmental exposures on human health, including mold illness, chemical toxicity, chronic infections, immune dysregulation, and mast cell activation syndrome.
Dr. McCann specializes in treating complex chronic illness by addressing root causes such as toxic burden, gut permeability, mitochondrial dysfunction, and nervous system imbalance. She is the founder of The Spring Center in Southern California and provides care to patients across multiple states. She also teaches and writes extensively on the intersection of environment, immunity, hormones, and healing.
Key Topics Covered
Why hormone symptoms are messengers, not the root problem

Environmental toxins and their impact on thyroid and hormone signaling

Mold exposure and its role in chronic illness and metabolic dysfunction

The gut hormone immune axis and why gut health is inseparable from hormone health

How plastics, PFAS, pesticides, and contaminated water disrupt endocrine function

Food related mold and toxin exposure, including grains, corn, and peanuts

Heavy metals, mercury accumulation, and bioaccumulation in the body

Why many patients struggle despite “normal” lab results

Critical labs often missed in conventional care, including thyroid conversion markers

The role of mitochondrial dysfunction and the cell danger response

Chronic stress, trauma, and nervous system dysregulation in hormone imbalance

Why perimenopause often reveals accumulated toxic burden

Small, practical steps to reduce toxic load and support healing
Links & Resources:
Dr. Kelly K. McCann, MD
🔗 Official Website
https://drkellymccann.com/
🔗 The Spring Center
https://thespringcenter.com/
🔗 LinkedIn Profile
https://www.linkedin.com/in/dr-kelly-mccann/
📲 Follow Dr. Cassie Smith & Modern Endocrine
💻 Website:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modern-endocrine.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
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56min
December 28, 202591: You Feel Tired but Labs Look Normal - The Hidden Nitric Oxide Deficiency No One Tests For with Dr. Nathan Bryan
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<<
What if many hormone, thyroid, and energy problems come down to a single overlooked molecule your body is quietly running out of?
In this episode of Hormones Metabolism in You, Dr. Cassie Smith sits down with nitric oxide expert Dr. Nathan Bryan to explore why nitric oxide is one of the most overlooked yet essential molecules in human health.
Together, they unpack nitric oxide’s powerful role in hormone signaling, thyroid function, gut motility, immune defense, blood flow, and mitochondrial energy production. Dr. Bryan explains how nitric oxide deficiency can contribute to fatigue, hormone resistance, insulin resistance, poor circulation, and chronic inflammation, even when labs appear “normal.”
They also discuss how modern lifestyle factors such as aging, chronic stress, poor diet, fluoride exposure, antiseptic mouthwash use, and long term antacid use can significantly impair nitric oxide production. Most importantly, this conversation offers practical, science backed strategies listeners can apply immediately to support nitric oxide levels and improve overall hormone health, energy, and longevity.
About the Guest
Dr. Nathan Bryan holds a Bachelor of Science in Biochemistry from the University of Texas at Austin and earned his doctoral degree from Louisiana State University School of Medicine in Shreveport, where he received the Dean’s Award for Excellence in Research. He completed postdoctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute.
In 2006, Dr. Bryan joined the faculty at the University of Texas Health Science Center at Houston under the recruitment of Nobel Laureate Dr. Ferid Murad. With over two decades of experience in nitric oxide research, he has made significant contributions to the field, resulting in numerous US and international patents and clinically impactful technologies.
Dr. Bryan is also a successful entrepreneur and Founder and CEO of Nitric Oxide Innovations, LLC, where he continues to advance nitric oxide based therapies and molecular medicine worldwide.
Key Topics Covered
What nitric oxide is and why it is essential for human health

How nitric oxide influences hormone signaling and receptor sensitivity

The connection between nitric oxide and thyroid function

Nitric oxide’s role in gut motility, digestion, and the oral microbiome

How nitric oxide supports immune defense and inflammation control

Mitochondrial energy production and cellular oxygen delivery

Why nitric oxide production declines with age

How stress, poor diet, and environmental exposures impair nitric oxide

The impact of fluoride, antiseptic mouthwash, and antacids on nitric oxide production

Common symptoms associated with nitric oxide deficiency

How impaired blood flow affects hormone delivery and tissue response
Links & Resources
Website: https://drnathansbryan.com/
LinkedIn: https://www.linkedin.com/in/drnathansbryan
Nitric Oxide Education:
https://www.n1o1.com/
https://www.no2u.com/
https://www.nitricoxideinnovations.com/

Shop N1O1 Products: https://www.awin1.com/cread.php?awinmid=115399&awinaffid=2702698

📲 Follow Dr. Cassie Smith & Modern Endocrine
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56min

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The podcast currently has 100 episodes available.

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