Could spike protein be the hidden culprit behind brain fog, cognitive decline, and even Alzheimer's disease? Dr. Mobeen Syed (also called Dr. Mobeen or DrBeen) joins me to discuss the concerning persistence of the spike protein in the body and its potential to accelerate the progression of neurodegenerative conditions.

In this thought-provoking conversation, you'll learn about the latest studies revealing the impact of the spike protein on brain health and Alzheimer's disease. Dr. Mobeen discusses how it lingers in the body long after infection or vaccination, potentially causing long-term damage. We’ll explore the mechanisms by which the spike protein enters the brain, disrupts the blood-brain barrier, and leads to inflammation and cognitive decline.

If you’re concerned about Alzheimer's or want to understand how to protect your brain, don't miss this episode. Get informed, and join us in the fight against cognitive decline.

This episode is sponsored by Organifi

- Get 20% off organic superfood blends at www.organifi.com/DRJOSH with code DRJOSH

“Controlling inflammation does not fix the problem, but it fixes or reduces the damage done because of the problem.” 

~ Dr. Mobeen Syed, MD, MSc

In this Episode

03:21 - Can spike protein persist in the brain for months or even years?

22:51 - How the spike protein damages the brain

46:45 - Spike protein and its role in endothelial cell dysfunction

53:36 - Vaccine-derived vs. infection-derived spike protein

1:06:49 - Managing spike protein damage: Is recovery possible?

1:19:19 - Interventional studies on TLR antagonists

Links to the Articles: 

-Spike Protein Fragments Promote Alzheimer’s Amyloidogenesis | ACS Applied Materials & Interfaces - https://pubs.acs.org/doi/10.1021/acsami.3c09815

-SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein | Molecular Psychiatry - https://www.nature.com/articles/s41380-022-01831-0?utm_source=chatgpt.com

-Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination | medRxiv - https://www.medrxiv.org/content/10.1101/2025.02.18.25322379v2

-Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination - https://www.medrxiv.org/content/10.1101/2025.02.18.25322379v2.full.pdf

-Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19: Cell Host & Microbe - https://www.cell.com/cell-host-microbe/fulltext/S1931-3128%2824%2900438-4?utm_source=chatgpt.com

-Unraveling the SARS-CoV-2 spike protein long-term effect on neuro-PASC - PMC - https://pmc.ncbi.nlm.nih.gov/articles/PMC11688492/?utm_source=chatgpt.com

-Full article: Detection of S1 spike protein in CD16+ monocytes up to 245 days in SARS-CoV-2-negative post-COVID-19 vaccine syndrome (PCVS) individuals - https://www.tandfonline.com/doi/full/10.1080/21645515.2025.2494934#d1e1497

-The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling - PMC - https://pmc.ncbi.nlm.nih.gov/articles/PMC8820157/?utm_source=chatgpt.com

-Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment | Nature Neuroscience - https://www.nature.com/articles/s41593-024-01576-9?utm_source=chatgpt.com

-SARS-CoV-2 and the spike protein in endotheliopathy: Trends in Microbiology - https://www.cell.com/trends/microbiology/fulltext/S0966-842X%2823%2900189-0?utm_source=chatgpt.com

-Duration of SARS-CoV-2 mRNA vaccine persistence and factors associated with cardiac involvement in recently vaccinated patients | npj Vaccines - https://www.nature.com/articles/s41541-023-00742-7?utm_source=chatgpt.com

Resources:

- Top Supplements for Alzheimer's Guide - https://bit.ly/drjoshguide

- Courses from Dr. Mobeen Syed - https://members.drbeen.com/courses

Connect with Dr. Mobeen Syed: 

- Website - https://www.drbeen.com/

- YouTube - https://www.youtube.com/@DrBeenMedicalLectures

Connect with Dr. Josh Helman, MD:

- Instagram - https://www.instagram.com/greenbrainsMD

- Facebook - https://www.facebook.com/greenbrainsmd/

- LinkedIn - https://www.linkedin.com/in/doctorjosh

- TikTok - https://www.tiktok.com/@greenbrainsmd

- YouTube - https://www.youtube.com/channel/UCUMtFP2icmNEhOaSsd-CrSg?sub_confirmation=1

- Others - https://linktr.ee/greenbrainsmd

Disclaimer: Please remember that this podcast is for informational purposes only and is not intended as medical advice. Always consult your doctor or healthcare professional before making any changes to your treatment plan.