https://www.jayfeldmanwellness.com/healthy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Timestamps:

0:00 – intro 

0:53 – misconceptions regarding the Randle cycle in the alternative health world 

4:57 – what is the Randle cycle? 

7:06 – what most people get wrong about the Randle cycle 

10:44 – fat oxidation leads to increased ROS production and a decreased NAD+/NADH ratio 

16:29 – how fat oxidation inhibits the utilization of carbohydrates 

21:03 – the Randle cycle shows the benefits of burning carbs for energy 

25:56 – how fat oxidation inhibits the utilization of carbohydrates cont’d 

26:57 – metabolic dysfunction, not glucose, drives insulin resistance and aging 

32:07 – fat metabolism causes a buildup of citrate which reduces glucose uptake and utilization 

38:39 – how glucose oxidation inhibits the uptake and utilization of fats 

45:32 – whether you can “activate” or “deactivate” the Randle cycle 

47:22 – glucose oxidation leads to an optimal NAD+/NADH ratio and decreased ROS production 

52:08 – the protective effects of CO2 and why the brain can’t use fats as a fuel 

53:17 – whether we should strive for metabolic flexibility 

55:55 – fat metabolism and ketone production as a mechanism for energy conservation and glucose sparing 

1:00:02 – insulin resistance as a state of excess fat metabolism and decreasing fat metabolism or stress hormones improves this state 

1:05:28 – should we avoid eating carbs and fats together due to the Randle cycle? 

1:08:08 – different cells, tissues, and organs can use different fuels at the same time