My guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health and well-being in both men and women. We discuss how to improve hormones using behavioral, nutritional, and exercise-based tools and safely and rationally approach supplementation and hormone therapies. We discuss testosterone and estrogen and how those hormones relate to fertility, mood, aging, relationships, disease pathologies, thyroid hormone, growth hormone, prolactin, dopamine and peptides that impact physical and mental health and vitality across the lifespan. The episode is rich with scientific mechanisms and tools for people to consider.

For the full show notes, visit hubermanlab.com.

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Timestamps

(00:00:00) Dr. Kyle Gillett, MD, Hormone Optimization   

(00:03:28) Sponsors: AG1, LMNT

(00:08:24) Preventative Medicine & Hormone Health 

(00:14:17) The Six Pillars of Hormone Health Optimization

(00:17:14) Diet for Hormone Health, Blood Testing

(00:20:21) Exercise for Hormone Health 

(00:21:06) Caloric Restriction, Obesity & Testosterone 

(00:23:55) Intermittent Fasting, Growth Hormone (GH), IGF-1

(00:29:08) Sleep Quality & Hormones

(00:35:03) Testosterone in Women

(00:38:55) Dihydrotestosterone (DHT), Hair Loss 

(00:43:46) DHT in Men and Women, Turmeric/Curcumin, Creatine

(00:50:10) 5-Alpha Reductase, Finasteride, Saw Palmetto 

(00:52:30) Hair loss, DHT, Creatine Monohydrate

(00:55:07) Hair Regrowth, Male Pattern Baldness

(00:58:12) Polycystic Ovary Syndrome (PCOS), Inositol, DIM

(01:04:00) Oral Contraception, Perceived Attractiveness, Fertility 

(01:10:31) Testosterone & Marijuana or Alcohol

(01:14:27) Sleep Supplement Frequency

(01:15:34) Testosterone Supplementation & Prostate Cancer 

(01:20:24) Prostate Health, Dietary Fiber, Saw Palmetto, C-Reactive Protein  

(01:24:05) Prostate Health & Pelvic Floor, Viagra, Tadalafil 

(01:30:54) Testosterone Replacement Therapy (TRT)

(01:35:17) Estrogen & Aromatase Inhibitors, Calcium D-Glucarate, DIM 

(01:39:28) Lifestyle Factors to Increase Testosterone/Estrogen Levels, Dietary Fats 

(01:45:34) Aromatase Supplements: Ecdysterone, Turkesterone

(01:47:04) Tongkat Ali (Long Jack), Estrogen/Testosterone levels 

(01:52:25) Fadogia Agrestis, Luteinizing Hormone (LH), Frequency

(01:56:44) Boron, Sex Hormone Binding Globulin (SHBG)

(01:58:13) Human Chorionic Gonadotropin (hCG), Fertility

(02:04:18) Prolactin & Dopamine, Pituitary Damage 

(02:08:34) Augmenting Dopamine Levels: Casein, Gluten, Vitamin E, Vitamin B6 (P5P)

(02:12:30) L-Carnitine & Fertility, TMAO & Allicin (Garlic) 

(02:18:19) Blood Test Frequency 

(02:19:41) Long-Term Relationships & Effects on Hormones

(02:25:33) Nesting Instincts: Prolactin, Childbirth & Relationships

(02:29:05) Cold & Hot Exposure, Hormones & Fertility

(02:32:34) Peptide Hormones: Insulin, Tesamorelin, Ghrelin 

(02:37:24) Growth Hormone-Releasing Peptides (GHRPs)

(02:39:38) BPC-157 & Injury, Dosing Frequency

(02:45:23) Uses for Melanotan 

(02:48:21) Spiritual Health Impact on Mental & Physical Health 

(02:54:18) Caffeine & Hormones 

(02:56:19) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Review, Apple Reviews, Sponsors, Supplements, Instagram, Twitter

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