Can doing lines help you live longer? That depends on what you’re taking. In this three-part series, I’m ranking drugs based on their ties to longevity, starting with ketamine and cocaine. I tested ketamine on myself to study its impacts on the brain — here’s what we found.  

Study Links:

Ketamine’s Effects on Epigenetic Age 

Extending Ketamine’s Therapeutic Window

Ibogaine Therapy for PTSD 

Hosts:

Bryan Johnson: Blueprint Founder

Kate Tolo: Blueprint Co-Founder

Dr. Mike Mallin: Lead Physician for Bryan Johnson

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Chapters: 

00:00 - Introduction 

03:14 - Social Norms Around Drugs 

08:59 - Psychedelics as Therapy: Overview 

10:20 - Cocaine 

17:15 - Fentanyl Dangers 

23:27 - Ketamine: Brain Impacts + Longevity 

41:29 - Measuring The Impacts of Psychedelics  

47:51 - Longevity Rankings: Cocaine + Ketamine