As a bright adventurous 16 year-old, Angela Tilley was thrilled to get a job in a busy London office. But after a year's unwanted attention from one of her co-workers, attention that today we would call stalking, she started having panic attacks on the way to work. The attacks became a debilitating daily occurrence, leaving her mentally and physically exhausted. Her courage in pushing back against her fears, forging a career and having a family came at a huge personal cost. But one seemingly innocuous purchase was about to change her life forever.

Angela tells Dr Sian Williams about how she overcame her challenges and how she managed to stop her phobia defining her life.

Husband and father, Larry O’Brien, loved the freedom his job as a long-distance lorry driver gave him. But on March 6th 1987, that freedom was almost lost in the horror of the Zeebrugge ferry disaster, in which almost 200 people lost their lives. Larry – who could not swim – risked his own life to pull 30 people to safety.

When 18-year-old Stacey Goodwin got a job at a bookies, she put a pound coin into a slot machine and won enough money for a night out with her pals. It was the trigger for a destructive gambling addiction that led to a life of shame, brutal isolation and deceit. The money she lost over an eight-year period was eye-watering – on one occasion, frittering away a £50,000 online win in a matter of days. Sometimes suicidal, and always lonely, it was the damage she did to those closest to her which hurt the most.

When her addiction saw her undermine the financial security of someone she loved, she reached a crossroads. Stacey tells Dr Sian Williams how she found the strength to ask for help - and turned her life around.

Producer: Tom Alban

Warning: This episode contains discussions around suicide. Details of help and support are available through the BBC Action Line at bbc.co.uk/actionline.

In 1977, Ed Stewart was a happy-go-lucky teenager with his whole life ahead of him. With a new engineering job, a girlfriend and a motorbike, life was good. But when he dropped in on a friend’s party, a violent row with another teenager - who was carrying a shotgun - turned Ed’s whole life on its head.

Ed had to learn to navigate the world in an entirely different way, but he made a success of it - becoming a piano tuner to the stars and counting Jools Holland and Brian Ferry as his customers. Despite a life of adversity, he tells Dr Sian Williams how not just one, but two Life Changing moments led him to be what he refers to as a “glass-three-quarters-full” kind of bloke.

Producer: Tom Alban

For Lisa Hover and her husband Andy, life on the Hampshire Dorset border with their family of four children seemed idyllic. Even when a routine sight test on their young daughter Annabelle picked up an abnormality, it all seemed manageable. But the abnormality turned out to be early sight loss, which itself masked a more severe and life shortening genetic condition. With no cure available, Annabelle was determined the most from her limited life span.

Lisa talks to Dr Sian Williams about the challenges, joys and sadness she experienced - and Annabelle's dream to have a white Christmas with all the family.

Producer: Tom Alban

As a young man, Mohammed, AKA MFA Zaman, arrived in Britain from Bangladesh with a working visa, a patron and a job lined up as a chef. On arrival though, the promises of a bright future turned to ashes when he became a victim of modern slavery. But at this lowest of low ebbs in his life, Mohammed decided that he needed to do something - and that something was to volunteer at an old people's community club in Lewisham, near where he was living.

Mohammed tells Dr Sian Williams how this life-changing decision helped him to find freedom.

Producer: Tom Alban

After a whirlwind romance, Paul Mason and his wife Isabel were in no doubt that they wanted to start a family. It was not easy, but eventually that ordinary miracle happened. And yet it was a little more than ordinary - because they discovered they were to be parents to triplets.

Paul tells Dr Sian Williams about the joyful and harrowing life-changing events of his children’s birth, and explains how the family have since discovered the extraordinary generosity of strangers.

Producer: Tom Alban

Mother-of-two young children, Tanja Bage, had always been a keen singer and performer, so she was increasingly aware of her shortness of breath. The diagnosis was cancer, which required almost immediate surgery to remove the tumour, and with it her vocal chords. She would be losing her voice, and she had just a week to prepare herself and her family.

Tanja tells Dr Sian Williams about navigating the challenges of motherhood whilst having to re-learn how to speak – and reveals an exciting new artistic venture which has changed her life.

Producer: Tom Alban

After moving to Los Angeles, 12-year-old Dan Edozie and his mother were left homeless and begging for food. Life was not easy: they slept where they could, sometimes on public transport, sometimes in the refuges of the city’s infamous Skid Row. But a chance separation from his mother was about to change his fortunes forever.

Dan tells Dr Sian Williams how this life-changing moment allowed him to take control of his own destiny and set his sights on sporting greatness.

Producer: Elaina Boeteng

Sarah Fairbairns spent much of her life feeling she was a bit different. Growing up in the 1960s and 70s, she gained the reputation of a wild child – from travelling to India, to dancing on stage with the cast of iconic counter-culture musical Hair. And yet all the while, she faced bouts of sadness and depression, and a confusion as to why that should be. Later in life, Sarah made a discovery about a medical childhood trauma that changed the way she viewed the world – and wrote in to Life Changing to share her experience.

Now in her seventies, Sarah speaks to Dr Sian Williams about how confronting her past has provided belated but extraordinary relief.

Producer: Tom Alban