Modern Healthspan

By Modern HealthspanHealth & Fitness

Modern Healthspan episodes

April 08, 2023 Rejuvenation With mRNA | Prof Vittorio Sebastiano Interview Series 2 Ep2
In this video Professor Sebastiano discusses how the mRNA is delivered to the specific cells and how the recent explosion of mRNA interest has changed the development landscape.

Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.

Turn Bio website
https://www.turn.bio/
Professor Sebastiano's lab at Stanford
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
https://pubmed.ncbi.nlm.nih.gov/32210226/

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9 min
April 02, 2023 Age Reversal By Epigenetic Reprogramming | Prof Vittorio Sebastiano Interview Series 2 Ep1
In this episode Professor Sebastiano introduces ERA, Epigenetic Reprogramming of Age technology and talks about his thoughts on some of the causes of aging

Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.

Turn Bio website
https://www.turn.bio/
Professor Sebastiano's lab at Stanford
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
https://pubmed.ncbi.nlm.nih.gov/32210226/

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
15% Discount on Renue By Science with Code MHS15 until May 01 2023
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

13 min
March 29, 2023 Ketones & The Aging Brain - Proj John Newman Ep5
In this episode Dr Newman talks about ketones as a fuel for the brain and how this becomes more important as we age and the brain can become less able to use glucose.

Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.

Dr Newman's lab at the Buck Institute
https://www.buckinstitute.org/lab/newman-lab/
And at University of California, San Francisco.
https://medicine.ucsf.edu/people/john-newman

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

8 min
March 26, 2023 Ketones & The ITP Lifespan Trials - Prof John Newman Ep4
In this episode Dr Newman talks the ITP lifespan trials that used butanediol but did not see a significant result. He covers what might have caused this and some of the chemistry behind butanediol and butyrate.
Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.

Dr Newman's lab at the Buck Institute
https://www.buckinstitute.org/lab/newman-lab/
And at University of California, San Francisco.
https://medicine.ucsf.edu/people/john-newman

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
9 min
March 22, 2023 Ketone Supplements & Human Trials - Prof John Newman Ep3
In this episode Dr Newman talks ways of boosting ketones through ketone supplements, what the different types are and what has been seen with them in human trials.
Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.

Dr Newman's lab at the Buck Institute
https://www.buckinstitute.org/lab/newman-lab/
And at University of California, San Francisco.
https://medicine.ucsf.edu/people/john-newman

NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
11 min
March 19, 2023 Long-Term Ketosis In Health & Lifespan - Prof John Newman Ep2
In this episode Dr Newman talks about experiments that he and other teams have run on mice lifespan and healthspan while they were on ketogenic diets.
Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.
Dr Newman's lab at the Buck
Institute
https://www.buckinstitute.org/lab/newman-lab/
And at University of California,
San Francisco.
https://medicine.ucsf.edu/people/john-newman

NOVOS Core & NOVOS Boost
https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with
discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science
products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
10 min
March 15, 2023 Ketones & Aging Science - Prof John Newman Ep1
In this episode Dr Newman discusses ketones and their impact on aging.
Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.
Dr Newman's lab at the Buck Institute
https://www.buckinstitute.org/lab/newman-lab/
And at University of California, San Francisco.
https://medicine.ucsf.edu/people/john-newman
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

13 min
March 08, 2023 Next Generation Therapies For Rejuvenation - Dr Noah Davidsohn Interview Series Ep5
In this episode Dr Davidsohn discusses the next generation therapies that Rejuvenate Bio are working on. We also discuss, klotho, RJB02 and his personal protocol.
Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases.
Rejuvenate Bio website
https://www.rejuvenatebio.com/
Dr Davidsohn's paper mentioned in the interview
A single combination gene therapy treats multiple age-related diseases
https://pubmed.ncbi.nlm.nih.gov/31685628/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
12 min
March 04, 2023 Road To Rejuvenation Human Trials - Dr Noah Davidsohn Interview Series Ep4
In this episode Dr Davidsohn discusses taking RJB01 to trial with humans for a rare heart disease and how gene therapy is viewed by the FDA.
Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases.
Rejuvenate Bio website
https://www.rejuvenatebio.com/
Dr Davidsohn's paper mentioned in the interview
A single combination gene therapy treats multiple age-related diseases
https://pubmed.ncbi.nlm.nih.gov/31685628/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
10 min
March 01, 2023 Targeting One Time Therapy For Heart Disease - Dr Noah Davidsohn Series Ep3
In this episode Dr Davidsohn discusses how the gene therapy helps with heart health and is only required one time.
Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases.
Rejuvenate Bio website
https://www.rejuvenatebio.com/
Dr Davidsohn's paper mentioned in the interview
A single combination gene therapy treats multiple age-related diseases
https://pubmed.ncbi.nlm.nih.gov/31685628/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
10 min

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