In the 75th episode of Cracking Addiction we discuss nitrous oxide or nangs and their medical uses and indications and the use of nitrous oxide as a euphorigenic and sedative substance of abuse. We discuss the side effects and harms associated with nitrous oxide use and emphasise in particular the functional B12 deficiency that can be associated with nitrous oxide use and in particular the neurological side effects and the treatment and management options for B12 deficiency. We also discuss the harms that can occur using the cannisters in which nitrous oxide is stored and the ease of availability of nitrous oxide and its increasing usage in the adolescent population.

Nitrous oxide, also known as "laughing gas," is a colorless, sweet-tasting gas that is used for a variety of medical and dental procedures. When inhaled, it can produce feelings of euphoria and relaxation.

While nitrous oxide may seem harmless, it can be dangerous when used improperly or in excessive amounts. Some of the potential dangers include:

• Oxygen deprivation: Nitrous oxide can decrease the amount of oxygen in the body, which can lead to brain damage or even death if used in large amounts or for prolonged periods of time.
• Numbness and tingling: Nitrous oxide can cause numbness and tingling in the fingers, toes, and lips, which can be permanent if used excessively.
• Fainting or dizziness: Nitrous oxide can cause fainting or dizziness, which can be dangerous if the person falls or injures themselves.
• Cold burns: Nitrous oxide canisters can become very cold when used, and can cause cold burns or frostbite if they come into contact with the skin.
• Addiction: Nitrous oxide can be addictive, and people who use it excessively may develop a tolerance to the drug and require more to achieve the same effects.

"Nangs" is a colloquial term for nitrous oxide canisters, particularly in Australia.