Podcast Notes Playlist: Latest Episodes

Aging is inevitable. Everybody grows old. Everyone dies.

We accept these statements as fact.

But what if they're just stories based on history and our current understanding of biology?

What if everything we think we know about aging is about to change?

Across the globe, scientists are working on treatments and therapies that are designed to extend healthy human lifespans well beyond what we know today.

At the bleeding edge of such breakthroughs you will find David Sinclair, PhD, one of the world’s leading scientific authorities on longevity, aging and how to slow its effects.

Returning for his second appearance on the podcast, David is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher at M.I.T. where, among other things, he co-discovered the cause of aging for yeast.

The co-founder of several biotechnology companies, David is also co-founder and co-chief editor of the journal Aging. His work has been featured in a variety of books, documentaries, and media, including 60 Minutes, Nightline and NOVA. He is an inventor on 35 patents, has been lauded as one of the Top 100 Australian Innovators, and made TIME magazine’s list of the 100 most influential people in the world.

In addition, David is the author of Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To -- a New York Times bestseller that proposes a radical new theory of aging. As he writes: “Aging is a disease, and that disease is treatable.”

Last year I convened my first conversation with David (RRP #436), a scintillating and science-heavy primer on all things human lifespan, aging and longevity. It was a runaway hit with the listeners -- and left me wanting to know more.

So today we pick up where we last left off, diving deeper into the physiological mechanisms that contribute to biological degeneration. And we go further into the current state of research to better understand what contributes to aging and what can be done to counteract it.

Call him a dreamer, but David believes living to 200+ is a plausible reality. If you could double your lifespan, how would this impact how you choose to live? What would it mean for the future of humanity? And for the ecological stability of the planet? The implications are profound.

Equal parts philosophic and scientific, this conversation will forever change the way you think about why you age and what you can do about it. And it will leave you armed simple lifestyle practices you can deploy -- intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat -- that will help you live younger and healthier for longer.

Brilliant and lovely, it’s an honor to once again share this man's wisdom with you today. So break out that pen and paper, because you're going to want to take notes on this one.

The visually inclined can watch it all go down on YouTube. And as always, the audio version streams wild and free on Apple Podcasts and Spotify.

I sincerely hope you enjoy the episode.

Peace + Plants,

Listen, Watch & Subscribe

Apple Podcasts | YouTube | Spotify | Stitcher | Google Podcasts

Thanks to this week’s sponsors

On Running: Born in the Swiss Alps, On Running is the world's fastest growing running brand. From their patented cushioning system to their gorgeous minimal design aesthetic, On has become my got to for all my trail and road running needs with gear that fits, performs and looks great. To learn more about On go to on-running.com/richroll, pick your favorite shoe or apparel piece, and run in it for 30 days after which you can keep ‘em or return ‘em for a full refund no questions asked - an amazing no risk deal.

Squarespace: The easiest way to create a beautiful website, blog, or online store for you and your ideas. Save 10% at checkout when visit squarespace.com/richroll and use the offer code RICHROLL at checkout.

Zip Recruiter: Search for jobs hiring in your area using ZipRecruiter’s job search engine – the best way to find a job. To find jobs hiring near you and apply with just 1 click, visit: ziprecruiter.com/richroll

Note: One of the best ways to support the podcast is to support the sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors".

SHOW NOTES

Check out David's NYT bestseller: Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To*

• Connect With David: Website | Facebook | Twitter | Instagram | LinkedIn
• Life Biosciences: Life Biosciences
• Podcast Notes: David Sinclair on The Rich Roll Podcast
• Harvard Medical School: The Sinclair Lab
• Harvard Medical School: Rewinding The Clock
• Harvard Magazine: Anti-Aging Approaches: David Sinclair's anti-aging science
• TIME Magazine: Is an Anti-Aging Pill on the Horizon?
• TIME Magazine: This Compound Can Reverse Aging in Mice. Will It Work in People?
• Longevity Facts: NMN and NAD Reverse Aging of Blood Vessels in New Study
• Inside Tracker: Q&A: How Harvard's David Sinclair Unlocked His Own Fountain of Youth
• Slate: Could A Pill Slow Aging? Geneticist David Sinclair Thinks So
• Next big Future: Anti-Aging Researcher David Sinclair Takes Metformin, NMN, NAD for Longevity
• YouTube: (VIDEO) David Sinclair Slowing down Aging | My NMN Journey
• TedMed: (VIDEO) "Can a pill a day help keep aging away?" | David Sinclair, PhD
• Book: Now We Are Six (Winnie-the-Pooh)* by A.A. Milne
• Supplement: M98 Micronized Resveratrol by Revgenetics*

Related Podcasts You Might Enjoy:

• RRP #436: David Sinclair On Extending Human Lifespan
• RRP #367: Fasting For Longevity With Valter Longo, Ph.D.
• RRP #139: How To Live To Be 100+ With Dan Buettner
• RRP #209: Rhonda Patrick, PhD On Longevity, Epigenetics & Microbiome Health

Thanks to Jason Camiolo for production, audio engineering and show notes; Margo Lubin and Blake Curtis for video, editing and graphics; portraits by Ali Rogers; and theme music by Ana Leimma.

*Disclosure: Books and products denoted with an asterisk are hyperlinked to an affiliate program. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.

for 1000s of delicious, customized plant-based recipes & so much more, check out our Plantpower Meal Planner

HOW CAN I SUPPORT THE PODCAST?

Tell Your Friends & Share Online!

Subscribe & Review:  iTunes | Spotify | Stitcher | Soundcloud | Google Podcasts

Donate: Check out our Patreon account

Support The Sponsors: One of the best ways to support the podcast is to support our sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors".

• If you’re going to eat a piece of produce’s skin or peel, buy organic
• Protein is the most satiating macronutrient; to facilitate weight loss, eat more protein
• If you’re eating a healthy, whole foods-heavy diet, aim to consume 3-5 grams of sodium per day (double what the American Heart Association recommends)
  • Avoid seat salt—it’s packed with microplastics; Himalayan pink salt is best
• Try to get 30 minutes of 1,000 lux intensity light before noon each day—this helps set the circadian rhythm
  • (There are a variety of phone apps that allow you to measure an environment’s light intensity)
• Chronic use of anticholinergic drugs (i.e., antihistamines, Benadryl, and many sleep aids) is associated with a dramatically increased risk for dementia
• One of the best things you can do to limit exposure to endocrine-disrupting chemicals: stop storing/cooking food in plastic

In this episode Sal, Adam & Justin speak with good friend and author Max Lugavere about his newest book, The Genius Life.

• Health is important to everybody. (1:41)
• Is Max getting into ‘tiffs’ over social media? (3:40)
• Making the case for organic vs non-organic. (6:24)
• Endocrine disruptors and their effect on our hormones. (9:45)
• The importance of seeking out the opposing view from your own. (14:08)
• Why is vegans' anger so misplaced? (17:50)
• The rising popularity of the carnivore diet. (21:30)
• Don’t Fork Around! The value of dietary protein. (24:00)
• Do not be afraid of a good quality salt! (27:05)
• How ultra-processed foods highjack your hunger levels. (31:34)
• What you eat vs when you eat and its impact on your circadian rhythm. (32:29)
• Are your lights carcinogenic to your health? (37:15)
• The Vigger Trigger. The importance of thermal exercise. (43:06)
• Chronic use of anticholinergic drugs and the dangers to our body. (52:05)
• What’s the problem with heating plastic containers in the microwave? (54:38)
• Fish consumption and mercury toxicity. (56:34)
• Taking caution when taking Nonsteroidal Anti-inflammatory Drugs (NSAIDs). (58:45)
• Knowledge is power. (1:02:17)
• The Genius Life: Heal Your Mind, Strengthen Your Body, and Become Extraordinary. (1:07:07)

Related Links/Products Mentioned

• February Promotion: MAPS Split ½ off! **Code “SPLIT50” at checkout**
• Pre-order ‘The Genius Life’ by Max Lugavere
• Leader of Largest US Organic Food Fraud Gets 10-Year Term
• Mind Pump 990: Max Lugavere on the Dangers of Plastics, Building a Social Media Page, Coping with Loss & MORE
• BPA levels in humans may be much higher than previously thought
• Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life - Book by Max Lugavere and Paul Grewal
• Mind Pump 1227: The 5 Most Important Supplements to Take
• Sodium Intake and All-Cause Mortality over 20 Years in the Trials of Hypertension Prevention
• Redmond Real Salt
• ‘Ultraprocessed’ foods may make you eat more, clinical trial suggests
• Lux Light Meter Free
• University of Eastern Finland: Frequent Sauna use Associated With Lower Cardiovascular Death Rate in men and Women
• Visit Infrared Sauna for an exclusive offer for Mind Pump listeners!
• Do Ibuprofen and NSAIDs Affect Athletic Performance?
• Visit NED for an exclusive offer for Mind Pump listeners!
• Mind Pump Free Resources

Featured Guest/People Mentioned

• Max Lugavere (@maxlugavere)  Instagram
• Website
• Podcast
• Ellen Vora, MD (@ellenvoramd)  Instagram

Layne Norton, PhD (@biolayne)  Instagram

• It’s equally important for women to optimize their lives around the infradian clock as it for everyone to optimize their lives around their circadian clock
• “Nature has designed women to feel good during each of the four cycle phases” – Alissa Vitti
• Pre-menopausal women shouldn’t intermittent fast beyond the 12-hour window between dinner and breakfast
• Fitness advice for women:
  • In the first half of your cycle, do more high-intensity training
  • “In the second half of a woman’s cycle, her metabolism speeds up—she needs more calories and there’s more cortisol present, so she should do basic strength training without the cardio” – Alissa Vitti

Alisa Vitti is a women’s hormone and functional nutrition expert and pioneer in female biohacking. She is the best selling author of WomanCode, and her new book, In the FLO.

Pierre Rochard (Kraken, Noded Podcast, Nakamoto Institute) and Saifedean Ammous (Bitcoin economist and author of The Bitcoin Standard) join me to talk about Bitcoin as Savings Technology and Number Go Up technology. This point is often misunderstood, so listen in for discussion on:

Pierre Rochard Links:

Saifedean Ammous Links:

Sponsor links:

Stephan Livera links: