Podcast Notes Playlist: Latest Episodes

What I learned from reading Confessions of an Advertising Man by David Ogilvy.

In this episode, I discuss Methyl​enedioxy​methamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and empathy, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry.

For the full show notes, visit hubermanlab.com.

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Timestamps

(00:00:00) MDMA “Ecstasy”

(00:04:37) Sponsors: Helix Sleep, ROKA, HVMN

(00:08:18) MDMA History & Synthesis; Legality

(00:14:45) MDMA, Methamphetamine (Meth), Dopamine & Serotonin

(00:23:30) MDMA vs Psychedelics vs Ketamine

(00:26:54) MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma

(00:33:36) Sponsor: AG1 (Athletic Greens)

(00:34:51) Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages

(00:45:48) Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD)

(00:52:36) Long-Term Effects, Threat Detection & PTSD

(00:56:14) MDMA, Social Connection & Empathy; Meth, SSRIs

(01:06:10) Sponsor: LMNT

(01:07:22) Oxytocin & MDMA

(01:16:10) Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl

(01:26:36) Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature

(01:37:07) Post-MDMA “Crash”, Prolactin & P‑5‑P

(01:43:07) PTSD & Trauma; Talk Therapy, SSRIs

(01:54:09) PTSD Treatment: Talk Therapy + MDMA

(02:02:46) MDMA & Addiction; Dissociative PTSD & Empathy

(02:09:47) Side-Effects?, MDMA Efficacy & Legality

(02:15:22) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter

Title Card Photo Credit: Mike Blabac

Disclaimer

Shaan's Free Workshop --> http://bit.ly/3INb6EV

Episode 462: Sam Parr (@TheSamParr) and Shaan Puri (@ShaanVP) talk with Alex Hormozi (@AlexHormozi), founder of GymLaunch and Acquisition.com, about what he regrets about selling his business and why he's pumped about starting a new one, how he spends his money, and his secret to a successful marriage.

Want to see more MFM? Subscribe to the MFM YouTube channel here.

Check Out Shaan's Stuff:

* Power Writing Course

* Daily Newsletter

Check Out Sam's Stuff:

* Hampton

* Ideation Bootcamp

* Copy That

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Show Notes:

(04:00) - Upsides and Downsides of being famous

(10:45) - Status of Acquisition

(31:55) - Regrets about selling

(41:30) - Why do people get mega rich?

(58:20) - Who do you admire?

(01:04:40) - Secrets of successful marriages

(01:13:30) - What products/brands are you obsessed with?

(01:18:10) - What are you doing with your money?

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Links:

* Acquisition

* Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel.

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Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more.

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Additional episodes you might enjoy:

• #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits

• #209 Gary Vaynerchuk - Why NFTS Are the Future

• #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto

* #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett

• ​​​​#218 - Why You Should Take a Think Week Like Bill Gates

• Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More

• How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

Rob Dyrdek is a former professional skateboarder, entrepreneur, reality TV star, venture capitalist and a producer.

What if you tracked every second of your life? What if you dialled in every process, calorie, action and thought to facilitate your best performance? What if you manifested a Playboy wife out of thin air by just wanting her a lot? Today we get to find out.

Expect to learn about Rob’s journey from a small-town kid to a globally successful entrepreneur, his rigorous system for intentionality and productivity, the crucial factors that propelled him towards success, the system behind Rob’s meticulous tracking of his daily activities, how Rob met his dream wife, Rob's bulletproof investment strategy, his thoughts on the personal development space and much more...

Sponsors:

Get over 37% discount on all products site-wide from MyProtein at https://bit.ly/proteinwisdom (use code: MODERNWISDOM)

Get 20% OFF with our code MODERNWISDOM at https://calderalab.com/modernwisdom to unlock your youthful glow and be ready for summer with Caldera + Lab!

Get 20% discount on House Of Macadamias’ nuts at https://houseofmacadamias.com/modernwisdom (use code MW20)

Extra Stuff:

Check out Rob's website - https://dyrdekmachine.com/

Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/

To support me on Patreon (thank you): https://www.patreon.com/modernwisdom

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Get in touch.

Instagram: https://www.instagram.com/chriswillx

Twitter: https://www.twitter.com/chriswillx

YouTube: https://www.youtube.com/modernwisdompodcast

Email: https://chriswillx.com/contact/ 

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Mark Zuckerberg is CEO of Meta. Please support this podcast by checking out our sponsors:

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PODCAST INFO:

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- Medium: https://medium.com/@lexfridman

OUTLINE:

Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.

(00:00) - Introduction

(05:38) - Jiu-jitsu competition

(23:01) - AI and open source movement

(35:32) - Next AI model release

(47:48) - Future of AI at Meta

(1:08:25) - Bots

(1:23:53) - Censorship

(1:38:34) - Meta's new social network

(1:45:20) - Elon Musk

(1:49:25) - Layoffs and firing

(1:56:55) - Hiring

(2:02:48) - Meta Quest 3

(2:09:45) - Apple Vision Pro

(2:16:00) - AI existential risk

(2:22:23) - Power

(2:25:55) - AGI timeline

(2:33:17) - Murph challenge

(2:38:33) - Embodied AGI

(2:41:39) - Faith

Drive with Dr. Peter Attia

Key Takeaways

• Check out The Drive Episode Page & Show Notes

Read the full notes @ podcastnotes.org

View the Show Notes Page for This Episode

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Sign Up to Receive Peter’s Weekly Newsletter

Tommy Wood is an Assistant Professor of Pediatrics at the University of Washington, where he studies brain injury and how lifestyle choices and environmental factors contribute to brain health, cognitive function, and chronic disease. In this episode, Tommy delves into the complexities of age-related cognitive decline and explores interventions to counteract it. Drawing from his experience working with Formula 1 drivers, he highlights the connection between cognitive function and the right type of demands and training leading to improvement. Next, he explores the various theories on the different types of pathology in dementia and neurodegeneration. He makes the case that a large fraction of dementia is preventable through lifestyle choices and nutrient status, and provides an in-depth overview of interventions and supplements that support cognitive function. Finally, he provides a comprehensive overview of head injuries, including concussions and traumatic brain injuries (TBIs), discussing symptoms, how to mitigate damage following an incident, and long-term management.

We discuss:

• Tommy’s professional work, unique skill sets, and interests [3:00];
• Age-related decline in cognitive function and memory [5:45];
• Improving brain function with the right level and type of demand [20:15];
• Formula 1 as a model for how to perform under high cognitive demand and how to increase multitasking capacity [31:30];
• Advice for the person reaching middle life looking to mitigate cognitive decline [37:45];
• Tasks and activities that support and improve cognitive function [45:30];
• Neuropathology of Alzheimer’s disease: exploring the role of amyloid and tau proteins [49:30];
• Why Tommy believes dementia research funding should be focused on environmental and lifestyle-based risk factors [1:05:15];
• Benefits of lowering homocysteine and boosting omega-3’s, and evidence-based supplements that support cognitive function [1:09:00];
• A unifying theory of dementia [1:20:45];
• How muscular strength can help with both the prevention and survivability of dementia [1:24:15];
• Head injuries: comparing concussions against traumatic brain injuries (TBIs), mitigating the damage after an incident, and the long-term management of head injuries [1:29:15];
• Is hyperbaric oxygen treatment helpful after a TBI? [1:45:45];
• Supplements that aid recovery from a TBI: creatine, DHA, and choline [1:49:30];
• Demands faced by F1 drivers, and testing interventions to improve their performance [1:57:30]; and
• More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

In this episode, my guest is Mary Helen Immordino-Yang, EdD, a professor of education and psychology at the University of Southern California (USC) who has done groundbreaking research on emotions, self-awareness and social interactions and how these impact the way we learn and change across our lifespan. She explains how an understanding of emotions can be leveraged to improve learning in kids and in adults, and how the education system should be altered to include new forms of exploration, rules, and emotional and social contexts to facilitate better learning and to include more diverse learning (and teaching) styles. This episode ought to be of interest to anyone interested in how we learn, human development in children and adults, as well as those generally interested in education, psychology or neuroscience.

For the full show notes, visit hubermanlab.com.

Thank you to our sponsors

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The Brain Body Contract

https://hubermanlab.com/tour

Timestamps

(00:00:00) Dr. Mary Helen Immordino-Yang

(00:02:11) Sponsors: Eight Sleep, HVMN, ROKA

(00:05:54) Inspiration, Awe & Story

(00:09:59) Brain-Body, Narratives

(00:15:58) Emotions, Durability & Lifespan

(00:21:47) Conjuring Stories, Historical Context & Emotion

(00:32:16) Sponsor: AG1

(00:33:30) Hierarchal Emotion Organization, Default Mode Network, Story & Emotion

(00:46:24) Emotional Development & Lifetime

(00:57:13) Narrative & Genocide; Checking Assumptions & Mental Flexibility

(01:05:22) Social Media, Cognitive Dissonance

(01:09:52) Education, Deconstructing Beliefs & Curiosity

(01:17:22) Sponsor: InsideTracker

(01:18:32) Emotion & Learning; Constructing Meaning

(01:28:59) Good Teachers & Curiosity

(01:33:25) Inter-disciplinary Education; Development & Culture

(01:50:58) Idea Exploration, Tolerance

(01:56:53) Reframing Education, Deconstructing Assumptions

(02:03:28) Safety, Creativity & Default Mode Network

(02:12:15) Civic Discourse & Education; Deconstructing Ideas

(02:27:31) “Mirror” Neurons, Shared Social Experiences

(02:35:49) Cold Exposure & Sickness; Role of Education

(02:38:51) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter

Title Card Photo Credit: Mike Blabac

Disclaimer

Infinite Loops

Key Takeaways 

• Hypnosis has a way of effectively communicating with the self-conscious and is the most efficient way to upgrade the mental software that we all have   
• The hypnotic state is a state of accelerated learning or relaxed focused attention where a person is more suggestible, which means it is easier for them to change the way they think or feel about something 
• Hypnosis is not widely used due to misconceptions, lack of public awareness, and lack of consistent training standards 
• It is more profitable to treat symptoms than to treat root causes; this creates perverse incentives for the healthcare industry  
• The subconscious mind is more likely to absorb negative suggestions than positive suggestions 
• Secondary gains can obstruct progress, meaning the person gets a benefit from having the problem so they subconsciously sabotage their efforts to resolve it 
• One of the most effective ways to change the behavior is to change the way they think about it 
• “World peace starts with inner peace. If you want to make the world a better place, you got to make yourself a better place.” – Todd Goodwin 

Read the full notes @ podcastnotes.org

Todd Goodwin is the founder of Goodwin Hypnosis, a hypnosis center based in North Carolina. He is a Board Certified Fellow of the National Guild of Hypnotists, a designation earned by only one in every 500 hypnotists.

As well as working with thousands of clients since opening Goodwin Hypnosis in 2007, Todd has co-facilitated hypnosis certification courses, created a book and accompanying 30-day hypnosis system designed to stop people from smoking, and given numerous presentations on hypnosis to physicians, students, and medical staff.

Todd joins the show to discuss some of the common myths & misconceptions around hypnosis.

Important Links:

• Goodwin Hypnosis
  
• Goodwin Hypnosis’ YouTube
  
• The Thinker and the Prover
  
• Our episode on Dr John Sarno
  
• The Six Stage Model of Behaviour Change
  

Show Notes:

• Hypnosis in our everyday lives
  
• Why isn’t hypnosis more widely used?
  
• “I don’t want someone in my head”
  
• “I can’t be hypnotized”
  
• Targeting the root causes of behavior
  
• Tension between the conscious & the unconscious
  
• How secondary gains can obstruct progress
  
• How to clear root fear
  
• Using language to elicit change
  
• Be curious about yourself; remember that you are worthy of love
  
• MORE!
  

Books Mentioned:

• Healing Back Pain; by John E. Sarno
  
• Influence: Science and Practice; by Robert Cialdini
  
• Frogs into Princes: Neuro Linguistic Programming; by Richard Bandler and John Grinder

The Best of Making Sense with Sam Harris

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Sam Harris speaks with Frank Ostaseski about death and dying—and about how the awareness of death can improve our lives in each moment.

Frank Ostaseski is a Buddhist teacher, international lecturer, and a leading voice in end-of-life care. In 1987, he co-founded the Zen Hospice Project, the first Buddhist hospice in America. In 2004, he created the Metta Institute to provide innovative educational programs and professional trainings that foster compassionate, mindfulness-based care. Mr. Ostaseski’s groundbreaking work has been widely featured in the media, including the Bill Moyers television series On Our Own Terms, the PBS series With Eyes Open, The Oprah Winfrey Show, and in numerous print publications. AARP magazine named him one of America’s 50 most innovative people. In 2001, he was honored by the Dalai Lama for his many years of compassionate service to the dying and their families. He is the author of The Five Invitations: Discovering What Death Can Teach Us About Living Fully.

mettainstitute.org

Fiveinvitations.com

 

Episodes that have been re-released as part of the Best of Making Sense series may have been edited for relevance since their original airing.

 

Welcome to a preview of the seventh Ask Me Anything (AMA) episode, part of the Huberman Lab Premium subscription.

The Huberman Lab Premium subscription was launched for two main reasons. First, it was launched in order to raise support for the standard Huberman Lab podcast channel — which will continue to come out every Monday at zero-cost. Second, it was launched as a means to raise funds for important scientific research. A significant portion of proceeds from the Huberman Lab Premium subscription will fund human research (not animal models) selected by Dr. Huberman, with a dollar-for-dollar match from the Tiny Foundation.

Subscribe to Huberman Lab Premium at https://hubermanlab.com/premium.

Timestamps

(00:00:00) Introduction

(00:01:45) Is It Possible to Get a Cold or Sick From Deliberate Cold Exposure?

(00:20:02) Huberman Lab Premium

In the full AMA episode, we discuss:

How Can You Increase Rapid Eye Movement (REM) Sleep?

What Experiment(s) Would You Like to Undertake in Regard to Physical or Mental Performance?

Articles

Immune system of cold-exposed and cold-adapted humans

Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

The Effects of Sleep Extension on the Athletic Performance of Collegiate Basketball Players

Sleep extension improves serving accuracy: A study with college varsity tennis players

The impact of extended sleep on daytime alertness, vigilance, and mood

Title Card Photo Credit: Mike Blabac

Disclaimer